¿Aún no está registrado?

Cree su cuenta. Regístrese en Elsevier y obtendrá: información relevante, máxima actualización y promociones exclusivas.

Registrarme ahora
Ayuda - - Regístrese - Teléfono 902 888 740
Buscar en

Indexada en:

Index Medicus/MEDLINE, Scopus, IBECS, IME, MEDES


  • SCImago Journal Rank (SJR):0,195
  • Source Normalized Impact per Paper (SNIP):0,103
Clin Invest Arterioscl 2002;14:258-71 - DOI: 10.1016/S0214-9168(02)78871-2
Fisiopatología de la enfermedad aterotrombótica coronaria
J.J. Badimona,c,, , B. Badimonb, V. Fusterc
a Cardiovascular Biology Research Laboratory
b Unidad de Trombosis y Arteriosclerosis. Centro de Investigación y Desarrollo. CSIC. Barcelona
c Cardiovascular Institute. Mount Sinai School of Medicine. Nueva York
El Texto completo solo está disponible en PDF
A.G. Zaman,G. Helft,S.G. Worthley,J.J. Badimon
The role of plaque rupture and thrombosis in coronary artery disease
Atherosclerosis, 149 (2000), pp. 251-266
V. Fuster,L. Badimon,J.J. Badimon,J.H. Chesebro
The pathogenesis of coronary artery disease and the acute coronary syndromes (1
N Engl J Med, 326 (1992), pp. 242-250 http://dx.doi.org/10.1056/NEJM199201233260406
H. Wellens
Cardiology: where to go from here?
Lancet, 354 (1999), pp. 8-10
C. Von Rokitansky
A manual of pathological anatomy, Berlin, Syndheman Soc, 4 (1852), pp. 261
N. Anitschow,S. Chalatow
Uber experimentelle Cholesterinstectase und ihre Bedeutung fur die Entstehung einiger pathologischer Prozesse
Centralbl Allg Path Anot, (1913), pp. 1-24
M.A. Gimbrone
Endothelial dysfunction, hemodynamic forces, and atherosclerosis
Thromb Haemost, 82 (1999), pp. 722-726
D.N. Ku,D.P. Giddens,C.K. Zarins,S. Glagov
Pulsatile flow and atherosclerosis in the human carotid bifurcation: positive correlation between plaque location and low oscillating shear stress
Arteriosclerosis, 5 (1985), pp. 293-302
A.M. Malek,S.L. Alper,S. Izunmo
Hemodynamic shear stress and its role in atherosclerosis
JAMA, 282 (1999), pp. 2035-4220
J.N. Topper,J. Cai,D. Falb,M.A.J. Gimbrone
Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress
Proc Natl Acad Sci USA, 93 (1996), pp. 10417-10422
J.K. Liao
Endothelium and acute coronary syndromes
Clin Chem, 44 (1998), pp. 1799-1808
P.M. Vanhoutte
Endothelium dysfunction and atherosclerosis
Eur Heart J, 18 (1997), pp. 19-29
G. Camejo,E. Hurt-Camejo,O. Wiklund,G. Bondjers
Association of apo B lipoproteins with arterial proteoglycans: pathological significance and molecular basis
Atherosclerosis, 139 (1998), pp. 205-222
J.A. Berliner,M. Navab,A.M. Fogelman,J.S. Frank,L.L. Demer,P.A. Edwards
Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics
Circulation, 91 (1995), pp. 2486-2496
G.K. Hansson
Immune mechanisms in atherosclerosis
Arterioscler Thromb Vasc Biol, 21 (2001), pp. 1876-1890
R. Ross
Atherosclerosis-an inflammatory disease
N Engl J Med, 340 (1999), pp. 115-126 http://dx.doi.org/10.1056/NEJM199901143400207
T. Collins,M.A. Read,A.S. Neish,M.Z. Whitley,D. Thanos,T. Maniatis
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers
FASEB J, 9 (1995), pp. 899-909
R. De Caterina,T. Bourcier,U. Laufs,V. LaFata,G. Lazzerini,A.S. Neish
Induction of endothelial-leukocyte interaction by interferon-gamma requires coactivation of nuclear factor-kappaB
Arterioscler Thromb Vasc Biol, 21 (2001), pp. 227-232
R.G. Collins,R. Velji,N.V. Guevara,M.J. Hicks,L. Chan,A.L. Beaudet
P-Selectin or intercellular adhesión molecule (ICAM) -1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice
J Exp Med, 191 (2000), pp. 189-194
Z.M. Dong,S.M. Chapman,A.A. Brown,P.S. Frenette,R.O. Hynes,D.D. Wagner
The combined role of P- and E-selectins in atherosclerosis
J Clin Invest, 102 (1998), pp. 145-152 http://dx.doi.org/10.1172/JCI3001
L. Gu,Y. Okada,S.K. Clinton,C. Gerard,G.K. Sukhova,P. Libby
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
Mol Cell, 2 (1998), pp. 275-281
S.J. Hwang,C.M. Ballantyne,A.R. Sharrett,L.C. Smith,C.E. Davis,A.M.J. Gotto
Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study
Circulation, 96 (1997), pp. 4219-4225
L.E. Rohde,C.H. Hennekens,P.M. Ridker
Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men
Am J Cardiol, 84 (1999), pp. 1018-1022
S.E. Nissen,P. Yock
Intravascular ultrasound: novel pathophysiological insights and current clinical applications
Circulation, 103 (2001), pp. 604-616
P. Schoenhagen,K.M. Ziada,S.R. Kapadia,T.D. Crowe,S.E. Nissen,E.M. Tuzcu
Extent and direction of arterial remodeling in stable versus unstable coronary syndromes: an intravascular ultrasound study
Circulation, 101 (2000), pp. 598-603
R. tCorti,Z.A. Fayad,V. Fuster,S.G. Worthley,G. Helft,J.H. Chesebro
Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, non-invasive MRI
Circulation, 104 (2001), pp. 249-252
R. Corti,V. Fuster,J.J. Badimon,R. Hutter,Z.A. Fayad
New understanding of atherosclerosis (clinically and experimentally) with evolving in vivo MRI technology
Ann NY Acad Sci, 947 (2001), pp. 181-195
D.J. Lefer,D.N. Granger
Oxidative stress and cardiac disease
Am J Med, 109 (2000), pp. 315-323
K.K. Griendling,R.W. Alexander
Oxidative stress and cardiovascular disease
Circulation, 96 (1997), pp. 3264-3265
M. Navab,J.A. Berliner,A.D. Watson,S.Y. Hama,M.C. Territo,A.J. Lusis
The Yin and Yang of oxidation in the development of the fatty streak: a review based on the 1994 George Lyman Duff Memorial Lecture
Arterioscler Thromb Vasc Biol, 16 (1996), pp. 831-842
H.C. Stary
Evolution and progressión of atherosclerotic lesiones in coronary arteries of children and young adults
Arteriosclerosis Thromb Vasc Biol, 9 (Suppl 1 (1989), pp. 19-132
R. Virmani,F.D. Kolodgie,A.P. Burke,A. Farb,S.M. Schwartz
Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions
Arterioscler Thromb Vasc Biol, 20 (2000), pp. 1262-1275
J.L. Goldstein,R.G. Anderson,M.S. Brown
Coated pits, coated vesicles, and receptor-mediated endocytosis
Nature, 279 (1979), pp. 679-685
M. Febbraio,E.A. Podrez,J.D. Smith,D.P. Hajjar,S.L. Hazen,H.F. Hoff
Tar-geted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
J Clin Invest, 105 (2000), pp. 1049-1056 http://dx.doi.org/10.1172/JCI9259
M.R. Bennett
Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture
Cardiovasc Res, 41 (1999), pp. 361-368
J.A. Glomset
The plasma lecithin:cholesterol acyltransferase reaction
J Lipid Res, 9 (1968), pp. 155-167
J.J. Badimon,L. Badimon,V. Fuster
Regressión of atherosclerotic lesions by high density lipoprotein plasma fractions in the cholesterol-fed rabbit
J Clin Invest, 85 (1990), pp. 1234-1241 http://dx.doi.org/10.1172/JCI114558
J.J. Badimon,L. Badimon,A. Gálvez,R. Dische,V. Fuster
The high density lipoprotein plasma fractions inhibit aortic fatty streak in cholesterol-fed rabbits
Lab Invest, 60 (1989), pp. 455-461
N. Duverger,H. Kruth,F. Emmanuel,J.M. Caillaud,C. Viglietta,G. Castro
Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits
Circulation, 94 (1996), pp. 713-717
A.S. Plump,C.J. Scott,J.L. Breslow
Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse
Proc Natl Acad Sci U S A, 91 (1994), pp. 9607-9611
P.K. Shah,J. Yano,O. Reyes,K.Y. Chyu,S. Kaul,C.L. Bisgaier
High-dose recombinant apolipoprotein A-I (milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilization
Circulation, 103 (2001), pp. 3047-3050
M. Navab,G.M. Anantharamaiah,S. Hama,D.W. Garber,M. Chaddha,G. Hough
Oral administration of an Apo A-I mimetic Peptide synthesized from Damino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol
Circulation, 105 (2002), pp. 290-292
T. Gordon,J.L. Probstfield,R.J. Garrison,J.D. Neaton,W.P. Castelli,J.D. Knoke
HDL and cardiovascular diseases: Four prospective studies
Circulation, 79 (1989), pp. 8-15
A.M.J. Gotto,E. Whitney,E.A. Stein,D.R. Shapiro,M. Clearfield,S. Weiss
Relation between baseline and on-treatment lipid parameters and first acute major coronary events in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS
G. Assman,H. Schulte,A. Von Eckardstein,Y. Huang
HDL-cho as a predictor of CHD: the PROCAM experience and pathophysiological implications for reverse cholesterol transport
Atherosclerosis, 124 (1996), pp. 11-20
V. Manninen,M.O. Elo,M.H. Frick,K. Haapa,O.P. Heinonen,P. Heinsalmi
Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study
JAMA, 260 (1988), pp. 641-651
H.B. Rubins,S.J. Robins,D. Collins,C.L. Fye,J.W. Anderson,M.B. Elam
Gemfibrozil for the secondary prevention on coronary heart disease in men with low levels of high density lipoprotein cholesterol
N Engl J Med, 341 (1999), pp. 410-418 http://dx.doi.org/10.1056/NEJM199908053410604
Expert Panel on Detection E, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
J Am Med Assoc, 285 (2001), pp. 2486-2497
J.C. Choy,D.J. Granville,D.W. Hunt,B.M. McManus
Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis
J Mol Cell Cardiol, 33 (2001), pp. 1673-1690 http://dx.doi.org/10.1006/jmcc.2001.1419
S.W. Fesik,Y. Shi
Controlling the caspases
Science, 294 (2001), pp. 1477-1478 http://dx.doi.org/10.1126/science.1062236
Y.J. Geng,L.E. Henderson,E.B. Levesque,M. Muszynski,P. Libby
Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells
Arterioscler Thromb Vasc Biol, 17 (1997), pp. 2200-2208
F.D. Kolodgie,J. Narula,N. Haider,R. Virmani
Apoptosis in atherosclerosis. Does it contribute to plaque instability?
Cardiol Clin, 19 (2001), pp. 127-139
R.A. Gottlieb,R.N. Kitsis
Seeing death in the living
Nature Med, 7 (2001), pp. 1277-1278 http://dx.doi.org/10.1038/nm1201-1277
X. Roucou,B. Antonsson,J.C. Martinou
Involvement of mitochondria in apoptosis
Cardiol Clin, 19 (2001), pp. 45-55
M.J. Davies
Going from immutable to mutable atherosclerotic plaques
Am J Cardiol, 88 (2001), pp. 2-9
E. Falk,P.K. Shah,V. Fuster
Coronary plaque disruption
Circulation, 92 (1995), pp. 657-671
J.A. Ambrose,M.A. Tannenbaum,D. Alexopoulos,C.E. Hjemdahl-Monson,J. Leavy,M. Weiss
Angiographic progressión of coronary artery disease and the development of myocardial infarction
J Am Coll Cardiol, 12 (1988), pp. 56-62
D. Giroud,J.M. Li,P. Urban,B. Meier,W. Rutishauser
Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography
Am J Cardiol, 69 (1992), pp. 729-732
W.C. Little,M. Constantinescu,R.J. Applegate,M.A. Kutcher,M.T. Burrows,F.R. Kahl
Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild to moderate coronary artery disease?
Circulation, 78 (1988), pp. 1157-1166
F.D. Kolodgie,A.P. Burke,A. Farb,H.K. Gold,J. Yuan,J. Narula
The thincap fibroatheroma: a type of vulnerable plaque: the major precursor lesión to acute coronarysyndromes
Curr Opin Cardiol, 16 (2001), pp. 285-292
P.R. Moreno,V.H. Bernardi,J. López-Cuéllar,A.M. Murcia,I.F. Palacios,H.K. Gold
Macrophages, smooth muscle cells, and tissue factor in unstable angina. Implications for cell-mediated thrombogenicity in acute coronary syndromes
Circulation, 94 (1996), pp. 3090-3097
P.R. Moreno,E. Falk,I.F. Palacios,J.B. Newell,V. Fuster,J.T. Fallon
Macrophage infiltration in acute coronary syndromes: implications for plaque rupture
Circulation, 90 (1994), pp. 775-778
A. Farb,A.P. Burke,A.L. Tang,Y. Liang,P. Mannan,J. Smialek
Coronary plaque erosion without rupture into a lipid core: a frequent cause of coronary thrombosis in sudden coronary death
Circulation, 93 (1996), pp. 1354-1363
P.K. Shah,E. Falk,J.J. Badimon,A. Fernández-Ortiz,A. Mailhac,G. Villareal-Levy
Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture
Circulation, 92 (1995), pp. 1565-1569
G.K. Sukhova,U. Schonbeck,E. Rabkin,F.J. Schoen,A.R. Poole,R.C. Billinghurst
Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques
Circulation, 99 (1999), pp. 2503-2509
G.K. Sukhova,G.P. Shi,D.I. Simon,H.A. Chapman,P. Libby
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
J Clin Invest, 102 (1998), pp. 576-583 http://dx.doi.org/10.1172/JCI181
U. Schonbeck,G.K. Sukhova,K. Shimizu,F. Mach,P. Libby
Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
Proc Natl Acad Sci USA, 97 (2000), pp. 458-463
C.K. Glass,J.L. Witztum
Atherosclerosis: the road ahead
Cell, 104 (2001), pp. 503-516
P.K. Shah,Z.S. Galis
Matrix metalloproteinase hypothesis of plaque rupture: players keep piling up but questions remain
Circulation, 104 (2001), pp. 1878-1880
G.T. Gerhard,P.B. Duell
Homocysteine and atherosclerosis
Curr Opin Lipidol, 10 (1999), pp. 417-428
N. Negoro,Y. Kanayama,M. Haraguchi,N. Umetani,M. Nishimura,Y. Konishi
Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy
J Clin Invest, 95 (1995), pp. 1140-1150 http://dx.doi.org/10.1172/JCI117762
L. Nathan,G. Chaudhuri
Estrogens and atherosclerosis
Annu Rev Pharmacol Toxicol, 37 (1997), pp. 477-515 http://dx.doi.org/10.1146/annurev.pharmtox.37.1.477
E. Falk
Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death: autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion
Circulation, 71 (1985), pp. 699-708
W.C. Roberts,L.M. Buja
The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction: a study of 107 necropsy patients
Am J Med, 52 (1972), pp. 425-443
H.M. Loree,R.D. Kamm,R.G. Stringfellow,R.T. Lee
Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels
Circ Res, 71 (1992), pp. 850-858
P.D. Richardson,M.J. Davies,G.V.R. Born
Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques
Lancet, 2 (1989), pp. 941-944
G. Helft,S.G. Worthley,V. Fuster,Z.A. Fayad,J.I. Osende,A.G. Zaman
In vivo quantification of atherosclerotic plaque composition by noninvasive high resolution MRI in rabbits: a histopathological correlation
Jacc, 35 (2000), pp. 478
G. Helft,S.G. Worthley,V. Fuster,A.G. Zaman,C. Schechter,J. Osende
Atherosclerotic aortic component quantification by noninvasive magnetic resonance: an in vivo study in rabbits
J Am Coll Cardiol, 37 (2001), pp. 1149-1154
S.G. Worthley,G. Helft,V. Fuster,Z.A. Fayad,A.G. Zaman,J.T. Fallon
Serial noninvasive in vivo MRI monitors progression and regression of individual atherosclerotic lesions in a rabbit model
J Am Coll Cardiol, 35 (2000), pp. 432
S.G. Worthley,G. Helft,V. Fuster,A.G. Zaman,Z.A. Fayad,J.T. Fallon
Serial in vivo MRI documents arterial remodeling in experimental atherosclerosis
Circulation, 101 (2000), pp. 586-589
X.Q. Zhao,C. Yuan,T.S. Hatsukami,E.H. Frechette,X.J. Kang,K.R. Maravilla
Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study
Arterioscler Thromb Vasc Biol, 21 (2001), pp. 1623-1629
C.R. Weiss,A.E. Arai,M.H. Bui,K.O. Agyeman,M.A. Waclawiw,R.S. Balaban
Arterial wall MRi characteristics are associated with elevated serum markers of inflammation in humans
J Magnetic Res Imaging, 14 (2001), pp. 698-704
R.T. Lee,A.J. Grodzinsky,E.H. Frank,R.D. Kamm,F.J. Schoen
Structure-dependent dynamic mechanical behavior of fibrous caps from human atherosclero-tic plaques
Circulation, 83 (1991), pp. 1764-1770
Y.J. Geng
Biologic effect and molecular regulation of vascular apoptosis in atherosclerosis
Curr Atheroscler Rep, 3 (2001), pp. 234-242
A. Van der Waal,A. Becker,C. Van der,P. Das Loos
Site of intimal rupture or erosión of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology
Circulation, 89 (1994), pp. 36-44
A. Fernández-Ortiz,J.J. Badimon,E. Falk,V. Fuster,B.J. Meyer,A. Mailhac
Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture
J Am Coll Cardiol, 23 (1994), pp. 1562-1569
V. Toschi,R. Gallo,M. Lettino,J.T. Fallon,S. Gertz,A. Fernández-Ortiz
Tissue factor activity modulates the thrombogenicity of human atherosclerotic plaques
Circulation, 95 (1997), pp. 594-599
J.J. Badimon,M. Lettino,V. Toschi,V. Fuster,M. Berrozpe,J.H. Chesebro
Local Inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques
Circulation, 99 (1999), pp. 1780-1788
U. Rauch,J. Osende,J.H. Chesebro,V. Fuster,D.A. Vorchheimer,K. Harris
Statins and Cardiovascular diseases: multiple effects of lipid-lowering therapy by statins
Atherosclerosis, 153 (2000), pp. 181-189
U. Rauch,J. Crandall,J. Osende,J.T. Fallon,J.H. Chesebro,V. Fuster
Increased thrombus formation relates to ambient blood glucose and leukocyte count in diabetes mellitus type 2
Am J Cardiol, 86 (2000), pp. 246-249
J. Osende,J.J. Badimon,V. Fuster,P. Herson,P. Rabito,R. Vidhun
Blood thrombogenicity in type 2 diabetes mellitus patients is associated with glycemic control
J Am Coll Cardiol, 38 (2001), pp. 1307-1312
L. Badimon,P. Martínez-González,T. Royo,R. Lassila,J.J. Badimon
A sudden increase in plasma epinephrine levels transiently enhances platelet deposition on severely damaged arterial wall. Studies in a porcine model
Thromb Haemost, 82 (1999), pp. 1736-1742
D. Shimbo,J. Child,K. Davidson,E. Geer,J.I. Osende,R. Reddy
Exaggerated serotonin-mediated platelet reactivity as a possible link in depressión and acute coronary syndromes
Am J Cardiol, 89 (2002), pp. 331-333
A.C. Villablanca,J.M. McDonald,J.C. Rutledge
Smoking and cardiovascular disease
Clin Chest Med, 21 (2000), pp. 159-172
J.J. Badimon,L. Badimon,V.T. Turitto
Platelet deposition at high shear rates is enhanced by high plasma cholesterol levels in vivo study in the rabbit model
Arterioscler Thromb, 11 (1991), pp. 395-402
H.N. Ginsberg,L.S. Huang
The insulin resistance syndrome: impact on lipoprotein metabolism and atherothrombosis
J Cardiovasc Risk, 7 (2000), pp. 325-331
P. Uusimaa,K. Kervinen,A. Kesaniemi,K. Peukurinen
Serum lipoprotein (a) level in relation to severity of coronary artery disease and coronary artery patency in acute myocardial infarction
Heart Vessels, 16 (2002), pp. 37-41
M. Cattaneo
Hyperhomocysteinaemia and atherothrombosis
Ann Med, 32 (2000), pp. 46-52
Correspondencia: Profesor de Medicina. Director del Cardiovascular Biology Research Laboratory. Cardiovascular Institute.Mount Sinai School of Medicine. New York, NY-10029
Copyright © 2002. Sociedad Espa??ola de Arteriosclerosis y Elsevier Espa??a, S.L.