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Clin Invest Arterioscl 2002;14:230-8 - DOI: 10.1016/S0214-9168(02)78868-2
Efectos de irbesartán y losartán en conejos hipercolesterolémicos
Effects of irbesartan and losartan in cholesterol-fed rabbits
E. Padilla, , M. Sanz, P. Ganado, T. Tejerina
Departamento de Farmacología. Facultad de Medicina. Universidad Complutense. Madrid
Introduction and objectives

This study was performed to examine the long-term effects of irbesartan and losartan, two angiotensin (AT1) receptor antagonists, on lipoproteins and vascular responsiveness in vessels isolated from hypercholesterolemic rabbits

Material and methods

Four groups of rabbits (n = 40) were used: group 0 (control group; n = 10); group 1 (hypercholesterolemic group, 0.5% [wt/wt] cholesterol-enriched diet; n = 10); group 2 (hypercholesterolemic + irbesartan 10 mg/kg/day; n = 10), and Group 3 (hypercholesterolemic + losartan 10 mg/kg/day; n = 10). The animals were maintained for 18 weeks


After 18 weeks of treatment levels of total cholesterol (TC) and low density lipoproteins (LDL) in irbesartan and losartan treated groups were significantly lower than those of Group 1 (α = 0.05; p < 0.05 and p < 0.01, respectively). Furthermore, levels of high density lipoproteins (HDL) were higher in the treated groups than in the hypercholesterolemic (α = 0.05; p < 0.05 and p < 0.01, respectively) when we consider the same level of total cholesterol in the hypercholesterolemic and the treated groups. Despite the effect of the drugs on the above mentioned parameters, treatment with irbesartan or losartan did not improve endotheliumdependent and independent relaxation in aortic and mesenteric rings. Treatment with irbesartan and losartan decreased NA-induced contraction in aortic rings with respect to the hypercholesterolemic group (α = 0.05; p < 0.05). In addition, irbesartan treatment improved the increase in serotonin-induced contraction in proximal coronary arteries with respect to the hypercholesterolemic group (α = 0.05; p < 0.001)


These results indicate that irbesartan and losartan restore NA-induced contraction in hypercholesterolemic rabbit-isolated arteries and improve lipoprotein profile in cholesterol-fed rabbits

Palabras clave
Irbesartán, Losartán, Antagonista del receptor de angiotensina II, Conejos alimentados con dieta rica en colesterol, Arterias (aorta coronaria mesentérica [quinta rama])
Key words
Irbesartan, Losartan, Angiotensin II receptor antagonist, Cholesterol-fed rabbit, Arteries (aorta coronary mesenteric [5th branch])
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Correspondencia: Departamento de Farmacología. Facultad de Medicina.Universidad Complutense. 28040 Madrid (E. Padilla teje@med.ucm.es)
Copyright © 2002. Sociedad Española de Arteriosclerosis y Elsevier España, S.L.