metricas
covid
Buscar en
Acta Otorrinolaringológica Española
Toda la web
Inicio Acta Otorrinolaringológica Española Risk of Onset of Second Neoplasms and Successive Neoplasms in Patients With a He...
Journal Information
Vol. 71. Issue 1.
Pages 9-15 (January - February 2020)
Share
Share
Download PDF
More article options
Visits
17
Vol. 71. Issue 1.
Pages 9-15 (January - February 2020)
Original article
Risk of Onset of Second Neoplasms and Successive Neoplasms in Patients With a Head and Neck Index Tumour
Riesgo de aparición de segundas neoplasias y neoplasias sucesivas en pacientes con un tumor índice de cabeza y cuello
Visits
17
Xavier Leóna,b,
Corresponding author
xleon@santpau.cat

Corresponding author.
, Jacinto Garcíaa, Montserrat Lópeza, Camilo Rodrigueza, Alfons Gutierreza, Miquel Quera
a Servicio de Otorrinolaringología. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
b Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (4)
Table 1. Location of the Second Neoplasms and Successive Neoplasms for the 4356 Patients Included in the Study.
Table 2. Frequency of Onset of Second Neoplasms and Second Neoplasms Associated With the Consumption of Tobacco and Alcohol in Accordance With Sex, Age When Diagnosed With Index Tumour, History of Toxic Substance Consumption and Location of Index Tumour.
Table 3. Multivariate Study Considering the Dependent Variable as the Appearance of Second Neoplasms and Second Neoplasms Associated With Tobacco and Alcohol Consumptions, Depending on Sex, Age on Diagnosis of the Index Tumour, the History of Toxic Substance Consumption and the Location of the Index Tumour.
Table 4. Second, Third and Fourth Neoplasm Free Survival at 5, 10 and 15 Years for Patients With an Index Tumour of the Head and Neck.
Show moreShow less
Additional material (1)
Abstract
Objective

To analyse the incidence of appearance of second and successive neoplasms in a cohort of head and neck squamous carcinoma patients.

Material and methods

We conducted a retrospective study with 4458 patients with an index tumour located in the head and neck diagnosed during the 1985–2016 period. We evaluated the incidence of appearance of second neoplasms and successive neoplasms over a period of 30 years.

Results

During the follow-up, 1203 patients 27.0 %) had a second neoplasm, 242 patients (5.4 %) a third neoplasm, 58 patients (1.3 %) a fourth neoplasm, and 8 patients (2 %) five or more successive neoplasms. The incidence of appearance of second neoplasms was 3.5 % per year, remaining relatively constant throughout the follow-up period. The patients with a second neoplasm had a higher risk of appearance of a third neoplasm, and those with a third neoplasm had a higher risk of a fourth. Seventy-eight percent of the second neoplasms, 88.0 % of the third neoplasms, and 89.6 % of the fourth neoplasms appeared in locations epidemiologically related to tobacco and alcohol use.

Conclusions

Second neoplasms after a head and neck index tumour appeared at a constant rate of 3.5 % per year throughout the entire follow-up period.

Keywords:
Second neoplasms
Successive neoplasms
index tumour
Squamous carcinoma of head and neck
Resumen
Objetivo

Analizar la incidencia de aparición de segundas neoplasias y neoplasias sucesivas en una cohorte de pacientes con un carcinoma escamoso de cabeza y cuello.

Material y métodos

Estudio retrospectivo realizado en 4.458 pacientes con un tumor índice localizado en cabeza y cuello diagnosticados durante el periodo 1985–2016. Se llevó a cabo una evaluación de la incidencia de aparición de segundas neoplasias y neoplasias sucesivas a lo largo de un periodo de 30 años.

Resultados

Durante el seguimiento un total de 1.203 pacientes (27%) contaron con la aparición de una segunda neoplasia, 242 (5.4%) con una tercera neoplasia, 58 (1.3%) con una cuarta, y 8 (0,2%) con cinco o más neoplasias. La incidencia de aparición de segundas neoplasias fue del 3.5% anual, manteniéndose prácticamente constante a lo largo del periodo de seguimiento. Los pacientes que sufrieron la aparición de una segunda neoplasia contaron con un riesgo aumentado de presentar una tercera neoplasia, y los pacientes con una tercera neoplasia con un riesgo aumentado de presentar una cuarta neoplasia. Un 78% de las segundas, un 88% de las terceras, y un 89.6% de las cuartas neoplasias aparecieron en localizaciones epidemiológicamente relacionadas con los consumos de tabaco y alcohol.

Conclusiones

Tras el diagnóstico y tratamiento de un tumor índice de cabeza y cuello los pacientes cuentan con un riesgo de aparición de una segunda neoplasia del 3.5% anual, y este riesgo permanece constante a lo largo del periodo de seguimiento a largo plazo.

Palabras clave:
Segundas neoplasias
Neoplasias sucesivas
Tumor índice
Carcinoma escamoso de cabeza y cuello

Article

These are the options to access the full texts of the publication Acta Otorrinolaringológica Española
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Acta Otorrinolaringológica Española

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos