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Inicio Medicina de Familia. SEMERGEN Tiroiditis de Graves Basedow asociada a terapia de alta actividad antirretrovír...
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Vol. 30. Issue 8.
Pages 411-413 (September 2004)
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Vol. 30. Issue 8.
Pages 411-413 (September 2004)
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Tiroiditis de Graves Basedow asociada a terapia de alta actividad antirretrovírica a propósito de un caso
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I. Prieto Checa*, M.V. García Espinosa, S. Martínez Machuca
Médicos de Familia. Centro de Salud la Ventilla. Área 5. Madrid
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La recuperación autoinmune asociada al tratamiento altamente activo en pacientes con virus de la inmunodeficiencia humana con importante descenso de linfocitos T CD4 al inicio de la terapia se asocia a reactivación de enfermedades víricas o micobacterianas coexistentes en el paciente, así como a la aparición de enfermedades autoinmunes como la alopecia o la tiroiditis de Graves Basedow.

En el caso que presentamos, la paciente fue diagnosticada de tiroiditis de Graves Basedow por la coincidencia de hipertiroidismo clínico y analítico, con anticuerpos antitiroglobulina elevados, hipercaptación difusa en la gammagrafía tiroidea y exoftalmos. Había iniciado tratamiento de alta efectividad antirretrovírica cuatro años antes, y presentaba niveles de linfocitos T CD4 normales, con niveles de viremia indetectables durante y después del proceso.

Palabras clave:
recuperación autoinmune
tiroiditis de Graves
terapia antirretrovírica
autoinmune
virus de la inmunodeficiencia humana

The immune restoration related to hig-activity antiretroviral therapy in patients starting the treatment with low level of T linfocytes CD4 is been associate with atypical presentation of mycobacterial or viruses diseases from coexisting infections, and to autoimmunes illness as alopecia or Graves' disease.

In this case the patient is been diagnosed with Graves' disease after four years of HAART on the basis of clinical and biological hyperthyroidism, hyperfixation diffuse in gammagraphy and presence of anti-TSH receptors antibodies, and exoftalmos. The CD4 cells count was normal, and the plasma HIV ribonucleic acid load undetectable.

Key words:
immune retoration
Graves' disease
antiretroviral therapy
HAART
autoimmunity
HIV
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Bibliografía
[1.]
F.J. Palella, K.M. Delaney, A.C. Moorman, M.O. Loveless, J. Fuhrer, G.A. Satten, et al.
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
N Engl J Med, 338 (1998), pp. 853-860
[2.]
G.W. Rutherford, K.A. Feldman, G.E. Kennedy.
Three-or four-versus two-drug antiretroviral maintenance regimens for HIV infection. Cochrane review.
The cochrane library, Issue, 3 (2002), pp. 9-18
[3.]
P. Price, N. Mathiot, R. Krueger, S. Stone, N.M. Keane, M.A. French.
Immune dysfunction and immune retoration disease in HIV patients given higly active antiretroviral therapy.
J Clin Virol, 22 (2001), pp. 279-287
[4.]
G.J. Dore, D.A. Cooper.
The impact oh HIV therapy on co-infection with hepatitis B and hepatitis C viruses.
Curr Opin Infect Dis, 14 (2001), pp. 749-755
[5.]
I. Sereti, N.J. Sarlis, E. Arioglu, M.L. Turner, J.M. Mican.
Alopecia universalis and Graves' disease after highly active antiretroviral therapy.
AIDS, 15 (2001), pp. 138-140
[6.]
V. Jubault, A. Penfornis, F. Schillo, et al.
Sequential Ocurrence of Thyroid Autoantibodies and Graves' Disease after Immune Restoration in Severely Immunocompromised Human Immunodeficiency Virus-1-Infected Patients.
J Clin End Metab, 85 (2000), pp. 4254-4257
[7.]
A. Fierabracci, C.P. Upton, N. Hajibagheri, G.F. Botazzo.
Lack of Detection of Retroviral Particles (HIAP-1) in the H9 T Cell Line Cocultured with Thyrocytes of Graves' Disease.
J Autoim, 16 (2001), pp. 457-462
[8.]
B. Autran, G. Carcelaint, T.S. Li, G. Gorochov, C. Blanc, M. Renaud, et al.
Restoration of the immune system with anti-retroviral therapy.
Immunol Lett, 66 (1999), pp. 207-211
[9.]
J.C. Gea-Banacloche, H.C. Lane.
Immune reconstitution in HIV infection.
AIDS, 13 (1999), pp. S25-S38
[10.]
J. Gilquin, J.P. Viard, V. Jubault, C. Sert, M.D. Kazatchkine.
Delayed ocurrence of Graves' disease after immune restoration with HAART.
Lancet, 352 (1998), pp. 292-300
Copyright © 2004. Elsevier España, S.L. y Sociedad Española de Medicina Rural y Generalista (SEMERGEN)
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