metricas
covid
Buscar en
Gastroenterología y Hepatología (English Edition)
Toda la web
Inicio Gastroenterología y Hepatología (English Edition) Autoimmune cerebellitis in Crohn’s disease
Journal Information

Statistics

Follow this link to access the full text of the article

Scientific letter
Autoimmune cerebellitis in Crohn’s disease
Cerebelitis autoinmune en enfermedad de Crohn
Enrique Práxedes Gonzáleza,b, Marta Lázaro Sáeza,b,
Corresponding author
alatriste83@hotmail.com

Corresponding author.
, Álvaro Hernández Martíneza,b, Esteban Alessandro Vogt Sáncheza,b, Antonio Arjona Padilloa,b, José Luis Vega Sáenza
a Unidad de Gestión Clínica de Aparato Digestivo, Complejo Hospitalario Torrecárdenas, Almería, Spain
b Unidad de Neurología Clínica y Diagnóstica, Complejo Hospitalario Torrecárdenas, Almería, Spain
Read
2428
Times
was read the article
263
Total PDF
2165
Total HTML
Share statistics
 array:24 [
  "pii" => "S2444382419302366"
  "issn" => "24443824"
  "doi" => "10.1016/j.gastre.2019.06.005"
  "estado" => "S300"
  "fechaPublicacion" => "2019-12-01"
  "aid" => "1418"
  "copyright" => "Elsevier España, S.L.U.. All rights reserved"
  "copyrightAnyo" => "2019"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Gastroenterol Hepatol. 2019;42:630-1"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0210570519301608"
      "issn" => "02105705"
      "doi" => "10.1016/j.gastrohep.2019.06.002"
      "estado" => "S300"
      "fechaPublicacion" => "2019-12-01"
      "aid" => "1418"
      "copyright" => "Elsevier España, S.L.U."
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Gastroenterol Hepatol. 2019;42:630-1"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 112
        "formatos" => array:2 [
          "HTML" => 78
          "PDF" => 34
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fica</span>"
        "titulo" => "Cerebelitis autoinmune en enfermedad de Crohn"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "630"
            "paginaFinal" => "631"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Autoimmune cerebellitis in Crohn&#39;s disease"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1052
                "Ancho" => 905
                "Tamanyo" => 58374
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Resonancia magn&#233;tica de cr&#225;neo&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Enrique Pr&#225;xedes Gonz&#225;lez, Marta L&#225;zaro S&#225;ez, &#193;lvaro Hern&#225;ndez Mart&#237;nez, Esteban Alessandro Vogt S&#225;nchez, Antonio Arjona Padillo, Jos&#233; Luis Vega S&#225;enz"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Enrique"
                "apellidos" => "Pr&#225;xedes Gonz&#225;lez"
              ]
              1 => array:2 [
                "nombre" => "Marta"
                "apellidos" => "L&#225;zaro S&#225;ez"
              ]
              2 => array:2 [
                "nombre" => "&#193;lvaro"
                "apellidos" => "Hern&#225;ndez Mart&#237;nez"
              ]
              3 => array:2 [
                "nombre" => "Esteban Alessandro"
                "apellidos" => "Vogt S&#225;nchez"
              ]
              4 => array:2 [
                "nombre" => "Antonio"
                "apellidos" => "Arjona Padillo"
              ]
              5 => array:2 [
                "nombre" => "Jos&#233; Luis"
                "apellidos" => "Vega S&#225;enz"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2444382419302366"
          "doi" => "10.1016/j.gastre.2019.06.005"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382419302366?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570519301608?idApp=UINPBA00004N"
      "url" => "/02105705/0000004200000010/v1_201912120625/S0210570519301608/v1_201912120625/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2444382419302378"
    "issn" => "24443824"
    "doi" => "10.1016/j.gastre.2019.06.006"
    "estado" => "S300"
    "fechaPublicacion" => "2019-12-01"
    "aid" => "1421"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Gastroenterol Hepatol. 2019;42:632-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 9
      "HTML" => 9
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Image of the month</span>"
      "titulo" => "Black esophagus&#44; is it as bad as it seems&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "632"
          "paginaFinal" => "633"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Es&#243;fago negro &#191;es tan malo como parece&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 807
              "Ancho" => 1007
              "Tamanyo" => 133605
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Endoscopic image of medial oesophagus showing necrotic oesophageal mucosa spreading proximally from the distal oesophagus&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Amparo Roa Colomo, Adelina Garc&#237;a Robles, Elena Ruiz Escolano"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Amparo"
              "apellidos" => "Roa Colomo"
            ]
            1 => array:2 [
              "nombre" => "Adelina"
              "apellidos" => "Garc&#237;a Robles"
            ]
            2 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Ruiz Escolano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210570519301657"
        "doi" => "10.1016/j.gastrohep.2019.06.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570519301657?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382419302378?idApp=UINPBA00004N"
    "url" => "/24443824/0000004200000010/v1_201912241024/S2444382419302378/v1_201912241024/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2444382419302354"
    "issn" => "24443824"
    "doi" => "10.1016/j.gastre.2019.06.004"
    "estado" => "S300"
    "fechaPublicacion" => "2019-12-01"
    "aid" => "1416"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Gastroenterol Hepatol. 2019;42:629-30"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
      "titulo" => "Drug-induced liver injury due to mesterolone&#58; A case report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "629"
          "paginaFinal" => "630"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Da&#241;o hep&#225;tico inducido por mesterolona&#58; a prop&#243;sito de un caso"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1010
              "Ancho" => 2205
              "Tamanyo" => 99377
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chronological course of laboratory abnormalities and their temporal relationship to the use of the drug responsible&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Domingo P&#233;rez Palacios, &#193;lvaro Gir&#225;ldez Gallego, Virginia Carballo Rubio, Ana Sol&#224; Fern&#225;ndez, Juan Manuel Pascasio Acevedo"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Domingo"
              "apellidos" => "P&#233;rez Palacios"
            ]
            1 => array:2 [
              "nombre" => "&#193;lvaro"
              "apellidos" => "Gir&#225;ldez Gallego"
            ]
            2 => array:2 [
              "nombre" => "Virginia"
              "apellidos" => "Carballo Rubio"
            ]
            3 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Sol&#224; Fern&#225;ndez"
            ]
            4 => array:2 [
              "nombre" => "Juan Manuel"
              "apellidos" => "Pascasio Acevedo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S021057051930158X"
        "doi" => "10.1016/j.gastrohep.2019.06.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021057051930158X?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382419302354?idApp=UINPBA00004N"
    "url" => "/24443824/0000004200000010/v1_201912241024/S2444382419302354/v1_201912241024/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
    "titulo" => "Autoimmune cerebellitis in Crohn&#8217;s disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "630"
        "paginaFinal" => "631"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Enrique Pr&#225;xedes Gonz&#225;lez, Marta L&#225;zaro S&#225;ez, &#193;lvaro Hern&#225;ndez Mart&#237;nez, Esteban Alessandro Vogt S&#225;nchez, Antonio Arjona Padillo, Jos&#233; Luis Vega S&#225;enz"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "Enrique"
            "apellidos" => "Pr&#225;xedes Gonz&#225;lez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Marta"
            "apellidos" => "L&#225;zaro S&#225;ez"
            "email" => array:1 [
              0 => "alatriste83@hotmail.com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "&#193;lvaro"
            "apellidos" => "Hern&#225;ndez Mart&#237;nez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Esteban Alessandro"
            "apellidos" => "Vogt S&#225;nchez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Antonio"
            "apellidos" => "Arjona Padillo"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Jos&#233; Luis"
            "apellidos" => "Vega S&#225;enz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Aparato Digestivo&#44; Complejo Hospitalario Torrec&#225;rdenas&#44; Almer&#237;a&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Neurolog&#237;a Cl&#237;nica y Diagn&#243;stica&#44; Complejo Hospitalario Torrec&#225;rdenas&#44; Almer&#237;a&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Cerebelitis autoinmune en enfermedad de Crohn"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1046
            "Ancho" => 900
            "Tamanyo" => 66803
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Magnetic resonance imaging of the head&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Acute cerebellitis is an inflammatory condition that often involves an infectious aetiology and usually follows a benign course&#46; Cases of autoimmune origin are rare&#44; and cases associated with inflammatory bowel disease are anecdotal&#46; Clinical suspicion&#44; as well as its correlation with complementary tests and a congruent therapeutic response&#44; leads in these few cases to the diagnosis of the condition&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 37-year-old-male with a personal history of Crohn&#8217;s disease in the ileum featuring a penetrating pattern with entero-enteric and ileo-vesical fistulas for which he had undergone surgery&#44; on treatment with 40&#8239;mg of adalimumab weekly&#44; went in for left hemicranial headache accompanied by paresthesia in his upper limbs and blurred vision in his left eye&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On examination&#44; the patient was alert and orientated&#44; presenting intermittent horizontal diplopia&#44; paresis on abduction of his left eye with no associated diplopia&#44; hyperreflexia and postural tremor in all four limbs&#44; with no dysmetria or dysdiadochokinesia&#46; While standing&#44; he maintained his balance and presented a gait with a slight increase in base of support&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">He underwent laboratory testing which showed&#58; glucose 114&#8239;mg&#47;dl&#59; urea 18&#8239;mg&#47;dl&#59; creatinine 0&#46;57&#8239;mg&#47;dl&#59; total bilirubin 0&#46;46&#8239;mg&#47;dl&#59; GGT 55 U&#47;l&#59; GOT 17 U&#47;l&#59; GPT 36 U&#47;l&#59; alkaline phosphatase 86 U&#47;l&#59; Na 143 mEq&#47;l&#59; K 3&#46;69 mEq&#47;l&#59; C-reactive protein 0&#46;45&#8239;mg&#47;dl&#59; haemoglobin 12&#46;5&#8239;g&#47;dl&#59; leukocytes 7&#44;200&#47;mm<span class="elsevierStyleSup">3</span>&#59; platelets 341&#44;000&#47;mm<span class="elsevierStyleSup">3</span>&#59; aPTT 24&#8239;s and D-dimer 0&#46;70&#8239;mg&#47;l&#46; No abnormalities were found in thyroid hormones&#44; immunoglobulins G&#44; A and M&#44; vitamin E&#44; vitamin B<span class="elsevierStyleInf">12</span> or folic acid&#46; Serology for HIV&#44; syphilis&#44; toxoplasma&#44; CMV&#44; Epstein&#8211;Barr virus&#44; brucella&#44; <span class="elsevierStyleItalic">Borrelia burgdorferi</span>&#44; <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span> and <span class="elsevierStyleItalic">Chlamydophila pneumoniae</span> was negative&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A CT scan of the head showed a slight diminishment of the extra-axial spaces in the posterior fossa with slight dilation of the third ventricle and lateral ventricles&#44; whereupon cerebral venous thrombosis was ruled out&#46; A thoracoabdominal CT scan and lumbar puncture showed no significant findings&#46; Magnetic resonance imaging of the brain was ordered and reported an increased signal on T2 and flair in the cerebellar lobes&#44; with a compression effect on the fourth ventricle&#44; accompanied by a slight drop in the cerebellar tonsils in the context of signs of hypertension in the posterior fossa secondary to cerebellitis&#44; of probable autoimmune aetiology &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Following empirical intravenous treatment with 50&#8239;mg of methylprednisolone every 24&#8239;h&#44; the patient showed clinical improvement and remained asymptomatic following five days of treatment&#44; with no signs of recurrence following six months of follow-up on an outpatient basis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The search for an aetiology led to further blood testing&#44; which revealed positive antinuclear antibodies &#40;titre 1&#47;160&#41; with a mottled pattern&#46; These things&#44; together with the patient&#8217;s good clinical response to treatment and imaging test findings&#44; led to a diagnosis of autoimmune cerebellitis in a patient with Crohn&#8217;s disease&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Acute cerebellitis is an isolated clinical syndrome that characteristically affects a paediatric population&#46; In most cases&#44; it involves an infectious&#44; post-infectious or post-vaccine phenomenon&#44; and its course is usually benign&#46; This disorder is rare in adults and has a varied aetiology&#44; with few cases of autoimmune origin&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in which it is possible to distinguish cases associated with paraneoplastic syndromes from idiopathic cases&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The majority of neurological disorders associated with inflammatory bowel disease include cerebrovascular disease&#44; peripheral neuropathies and demyelinating diseases&#59; the finding of hypercoagulation phenomena promotes the development of venous sinus thrombosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Clinically&#44; it presents with varied manifestations ranging from mild cerebellar signs to signs and symptoms characteristic of brain stem impairment&#46; Generally&#44; the syndrome starts with ataxia&#44; myoclonus and spontaneous abnormalities of eye movements&#44; to which headache&#44; nausea&#44; fever&#44; altered level of consciousness&#44; seizures&#44; meningeal signs and other cerebellar signs are added&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Radiologic imaging of cerebellitis is variable&#58; a CT scan may reveal modest low-density symmetrical and bilateral changes in the cerebellar hemispheres&#44; which may be overlooked&#46; Magnetic resonance imaging showed hypointense signals on T1 and hyperintense signals on T2 and sometimes cerebellar impairment may extend to the brain stem&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Treatment varies by aetiology and clinical course&#44; ranging from medical treatment to approaches that involve surgical decompression and external ventricular drainage in cases of obstructive hydrocephalus secondary to fulminant cerebellitis&#46; In general&#44; as in inflammatory bowel disease&#44; management of this condition is based on the use of corticosteroids and immunosuppressants&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However&#44; the rarity of these cases makes it difficult to conduct studies on the potential benefits of immunosuppressive treatment for the condition&#8217;s course and recurrence&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Pr&#225;xedes Gonz&#225;lez E&#44; L&#225;zaro S&#225;ez M&#44; H&#233;rn&#225;ndez Mart&#237;nez &#193;&#44; Vogt S&#225;nchez EA&#44; Arjona Padillo A&#44; Vega S&#225;enz JL&#46; Cerebelitis autoinmune en enfermedad de Crohn&#46; Gastroenterol Hepatol&#46; 2019&#46; <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.gastrohep.2019.06.002">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;gastrohep&#46;2019&#46;06&#46;002</span></p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1046
            "Ancho" => 900
            "Tamanyo" => 66803
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Magnetic resonance imaging of the head&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant cerebellitis with radiological recurrence in an adult patient with Crohn&#8217;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;P&#46; Flanagan"
                            1 => "A&#46;A&#46; Rabinstein"
                            2 => "N&#46; Kumar"
                            3 => "K&#46; Schroeder"
                            4 => "O&#46;H&#46; Kantarci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jns.2013.09.017"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "2014"
                        "volumen" => "336"
                        "numero" => "January"
                        "paginaInicial" => "247"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24090762"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurologic disorders associated with inflammatory bowel disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Benavente"
                            1 => "G&#46; Mor&#237;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-1331.2010.03095.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Neurol"
                        "fecha" => "2011"
                        "volumen" => "18"
                        "paginaInicial" => "138"
                        "paginaFinal" => "143"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20500801"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute cerebellar ataxia&#44; acute cerebellitis&#44; and opsoclonus-myoclonus syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Desai"
                            1 => "W&#46;G&#46; Mitchell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0883073812450318"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Child Neurol"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "1482"
                        "paginaFinal" => "1488"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22805251"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant cerebellitis&#58; a fatal&#44; clinically isolated syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Kamate"
                            1 => "V&#46; Chetal"
                            2 => "V&#46; Hattiholi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.pediatrneurol.2009.03.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Neurol"
                        "fecha" => "2009"
                        "volumen" => "41"
                        "paginaInicial" => "220"
                        "paginaFinal" => "222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19664542"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabotropic glutamate receptor type 1 autoantibody-associated cerebellitis&#58; a primary autoinmune disease&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Marignier"
                            1 => "F&#46; Chenevier"
                            2 => "V&#46; Rogemond"
                            3 => "P&#46; Sillevis Smitt"
                            4 => "C&#46; Renoux"
                            5 => "G&#46; Cavillon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archneurol.2010.51"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "2010"
                        "volumen" => "67"
                        "paginaInicial" => "627"
                        "paginaFinal" => "630"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20457964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/24443824/0000004200000010/v1_201912241024/S2444382419302366/v1_201912241024/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "77930"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/24443824/0000004200000010/v1_201912241024/S2444382419302366/v1_201912241024/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382419302366?idApp=UINPBA00004N"
]
Article information
ISSN: 24443824
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 October 45 10 55
2024 September 67 10 77
2024 August 51 15 66
2024 July 56 16 72
2024 June 36 7 43
2024 May 45 4 49
2024 April 31 6 37
2024 March 43 10 53
2024 February 39 5 44
2024 January 49 6 55
2023 December 43 3 46
2023 November 82 6 88
2023 October 71 9 80
2023 September 48 4 52
2023 August 63 4 67
2023 July 55 8 63
2023 June 62 5 67
2023 May 99 3 102
2023 April 78 1 79
2023 March 92 1 93
2023 February 81 7 88
2023 January 78 7 85
2022 December 93 12 105
2022 November 96 10 106
2022 October 64 8 72
2022 September 63 12 75
2022 August 62 8 70
2022 July 55 9 64
2022 June 57 10 67
2022 May 40 6 46
2022 April 50 6 56
2022 March 54 11 65
2022 February 80 7 87
2022 January 81 13 94
2021 December 53 4 57
2021 May 1 0 1
2020 May 2 0 2
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos