Letter to the Editor
Redefining the paradigm of immunization in immunocompromised post-pandemic patients
Redefiniendo el paradigma de la vacunación en inmunodeprimidos después de la pandemia
a Servicio Medicina Preventiva y Salud Pública, Hospital Vital Álvarez Buylla, Mieres, Asturias, Spain
b Grupo de Investigación en Epidemiología y Salud Pública, Instituto de Investigación Valle de Hebrón, Barcelona, Spain
c Dirección General de Salud Pública, Consejería de Sanidad, Junta de Castilla y León, Valladolid, Spain
Read
147
Timeswas read the article
50
Total PDF
97
Total HTML
Share statistics
array:24 [ "pii" => "S2529993X23001016" "issn" => "2529993X" "doi" => "10.1016/j.eimce.2023.04.002" "estado" => "S300" "fechaPublicacion" => "2023-10-01" "aid" => "2657" "copyright" => "Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica" "copyrightAnyo" => "2022" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Enferm Infecc Microbiol Clin. 2023;41:524-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0213005X22001896" "issn" => "0213005X" "doi" => "10.1016/j.eimc.2022.09.006" "estado" => "S300" "fechaPublicacion" => "2023-10-01" "aid" => "2657" "copyright" => "Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Enferm Infecc Microbiol Clin. 2023;41:524-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>" "titulo" => "Redefiniendo el paradigma de la vacunación en inmunodeprimidos después de la pandemia" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "524" "paginaFinal" => "525" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Redefining the paradigm of immunization in immunocompromised post-pandemic patients" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Fernández-Prada, Magda Campins-Martí, Sonia Tamames-Gómez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "María" "apellidos" => "Fernández-Prada" ] 1 => array:2 [ "nombre" => "Magda" "apellidos" => "Campins-Martí" ] 2 => array:2 [ "nombre" => "Sonia" "apellidos" => "Tamames-Gómez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2529993X23001016" "doi" => "10.1016/j.eimce.2023.04.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X23001016?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X22001896?idApp=UINPBA00004N" "url" => "/0213005X/0000004100000008/v1_202310030703/S0213005X22001896/v1_202310030703/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2529993X23001934" "issn" => "2529993X" "doi" => "10.1016/j.eimce.2023.06.003" "estado" => "S300" "fechaPublicacion" => "2023-10-01" "aid" => "2717" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Enferm Infecc Microbiol Clin. 2023;41:525-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Amphotericin B deoxycolate availability in Spain" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "525" "paginaFinal" => "526" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Disponibilidad de anfotericina B desoxicolato en España" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "David Campany-Herrero, Òscar Len-Abad" "autores" => array:2 [ 0 => array:2 [ "nombre" => "David" "apellidos" => "Campany-Herrero" ] 1 => array:2 [ "nombre" => "Òscar" "apellidos" => "Len-Abad" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213005X23000587" "doi" => "10.1016/j.eimc.2023.04.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X23000587?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X23001934?idApp=UINPBA00004N" "url" => "/2529993X/0000004100000008/v1_202310130444/S2529993X23001934/v1_202310130444/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2529993X23001880" "issn" => "2529993X" "doi" => "10.1016/j.eimce.2023.04.022" "estado" => "S300" "fechaPublicacion" => "2023-10-01" "aid" => "2716" "copyright" => "Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Enferm Infecc Microbiol Clin. 2023;41:521-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Proposal for antimicrobial therapy stewardship of lower respiratory tract infection in mechanically-ventilated patients based upon the Biofire® Filmarray® Pneumonia Plus panel results" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "521" "paginaFinal" => "523" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Propuesta para la administración de la terapia antimicrobiana en la infección del tracto respiratorio inferior en pacientes con ventilación mecánica basada en los resultados del panel Biofire® Filmarray® Pneumonia Plus" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2683 "Ancho" => 3341 "Tamanyo" => 651174 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Early adjustment of empirical antimicrobial therapy in patients with suspicion of ventilator-associated lower respiratory tract bacterial infection based on the BioFire® FilmArray® Pneumonia/Pneumonia plus Panel (FA-PP) results. The following microorganisms are targeted by FA-PP: <span class="elsevierStyleItalic">Acinetobacter calcoaceticus-baumannii complex</span>, <span class="elsevierStyleItalic">Enterobacter cloacae</span>, <span class="elsevierStyleItalic">Escherichia coli</span>, <span class="elsevierStyleItalic">Haemophilus influenzae</span>, <span class="elsevierStyleItalic">Klebsiella aerogenes</span>, <span class="elsevierStyleItalic">Klebsiella oxytoca</span>, <span class="elsevierStyleItalic">Klebsiella pneumoniae</span> group, <span class="elsevierStyleItalic">Moraxella catarrhalis</span>, <span class="elsevierStyleItalic">Proteus</span> spp., <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>, <span class="elsevierStyleItalic">Serratia marcescens</span>, <span class="elsevierStyleItalic">Staphylococcus aureus</span>, <span class="elsevierStyleItalic">Streptococcus agalactiae</span>, <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>, <span class="elsevierStyleItalic">Streptococcus pyogenes</span>, <span class="elsevierStyleItalic">Chlamydia pneumoniae</span>, <span class="elsevierStyleItalic">Legionella pneumophila</span>, <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span>, <span class="elsevierStyleItalic">Adenovirus</span>, <span class="elsevierStyleItalic">Coronavirus</span>, <span class="elsevierStyleItalic">Human metapneumovirus</span>, <span class="elsevierStyleItalic">Human rhinovirus/enterovirus</span>, <span class="elsevierStyleItalic">Influenza A virus</span>, <span class="elsevierStyleItalic">Influenza B virus</span>, <span class="elsevierStyleItalic">Parainfluenza virus</span>, and <span class="elsevierStyleItalic">Respiratory syncytial virus.</span> EAT, empirical antimicrobial therapy; ESBL, extended spectrum β-lactamase; GNB, Gram-negative bacteria; GPB, Gram-positive bacteria; MRSA, methicillin-resistant <span class="elsevierStyleItalic">Staphylococcus aureus</span>.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mª Ángeles Clari, Nieves Carbonell, Eliseo Albert, David Navarro" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Mª Ángeles" "apellidos" => "Clari" ] 1 => array:2 [ "nombre" => "Nieves" "apellidos" => "Carbonell" ] 2 => array:2 [ "nombre" => "Eliseo" "apellidos" => "Albert" ] 3 => array:2 [ "nombre" => "David" "apellidos" => "Navarro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X23001880?idApp=UINPBA00004N" "url" => "/2529993X/0000004100000008/v1_202310130444/S2529993X23001880/v1_202310130444/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Redefining the paradigm of immunization in immunocompromised post-pandemic patients" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "524" "paginaFinal" => "525" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "María Fernández-Prada, Magda Campins-Martí, Sonia Tamames-Gómez" "autores" => array:3 [ 0 => array:4 [ "nombre" => "María" "apellidos" => "Fernández-Prada" "email" => array:2 [ 0 => "mariafdezprada@gmail.com" 1 => "maria.fernandezp@sespa.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Magda" "apellidos" => "Campins-Martí" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Sonia" "apellidos" => "Tamames-Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio Medicina Preventiva y Salud Pública, Hospital Vital Álvarez Buylla, Mieres, Asturias, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Grupo de Investigación en Epidemiología y Salud Pública, Instituto de Investigación Valle de Hebrón, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Dirección General de Salud Pública, Consejería de Sanidad, Junta de Castilla y León, Valladolid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Redefiniendo el paradigma de la vacunación en inmunodeprimidos después de la pandemia" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Immunocompromised patients continue to be a challenge for the healthcare system. The application of new immunosuppressive treatments, as well as their greater survival, mean that this group of patients is continuously growing, while the efficacy with which current information systems can identify these patients within the general population is limited. For these reasons and despite the efforts of the Servicios de Medicina Preventiva y Salud Pública (SMPYSP) [Preventive Medicine and Public Health Services], as well as Primary Care (PC) services, the strategies implemented have proven to be insufficient to achieve the desired vaccination coverage in risk groups.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This coverage has at least three possible levels of intervention and management: (1) micro-management, by the SMPYSP and PC services that carry out the vaccination instructions issued by their reference health authority; (2) meso-management, by the Health Care and Public Health Directorates that encompass both these hospital and PC services, and (3) macro-management, through health policies and the strategic approach represented by the Health Services and Health Departments.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The interconnection of these three levels is required for a factual and significant change of course in improving vaccination coverage in risk groups.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Vaccination of immunocompromised patients has reached an inflection point in recent years. The COVID-19 pandemic has highlighted the above limitations by requiring actions that until now had not been carried out in the field of vaccinology. On the one hand, for the first time vaccination in these patients is being actively and rapidly prioritised due to their increased risk of serious infection. Secondly, also for the first time, the health authorities are making an effort to identify this group,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> as well as to determine its size within the general population.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Lastly, there has been a positive normalisation of the immunocompromised concept among citizens and those affected through self-defining and actively demanding priority vaccination. Thus, albeit unintentionally, all of the above has led to the social construction of a culture of protection for immunocompromised patients, which had been little rooted until now.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Could what was experienced politically and socially during the pandemic be used to improve non-COVID-19 vaccination coverage in this group? How could we reintroduce and strengthen vaccination strategies for the immunocompromised?</p><p id="par0025" class="elsevierStylePara elsevierViewall">In this letter to the editor, the authors propose promoting the vaccination of risk groups through the explicit incorporation of vaccines into the Procesos Asistenciales Integrados (PAIs) [Integrated Care Processes], or Programas Clave de Atención Interdisciplinar (PCAIs) [Key Interdisciplinary Care Programmes],<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as they are called in some autonomous communities. PAIs are defined as the "set of activities carried out by healthcare providers (preventive strategies, diagnostic tests and therapeutic activities) to increase the level of health and the degree of satisfaction of the population", and are created with the aim of reaching an agreement, among the different specialties, professionals and levels of care involved in a health problem, on the role of each professional in order to achieve quality care, and to formalise the agreement in a care process shared by all of them.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The PAIs are driven and promoted by the Health Services and Health Departments, being a macro-management strategy aimed at improving healthcare and public health. Yet despite the fact that most of the published documents address diseases with a specific indication for vaccination (solid organ tumours, transplants, chronic obstructive pulmonary disease, etc.), hardly any direct mention is made of the need to improve the protection of these patients through vaccines.</p><p id="par0030" class="elsevierStylePara elsevierViewall">We believe that the PAIs meet the ideal characteristics (multidisciplinary approach, preventive strategy and involvement of managers) to be able to integrate the vaccination of high-risk patients and review their vaccination schedule in accordance with current recommendations. The leap in vaccination of immunocompromised patients, from micro-management (SMPYSP and PC) to macro-management (Health Services and Health Departments), and the involvement of all stakeholders through tools already available with which managers and professionals are familiar, is necessary if we really want to improve vaccination coverage in patients at risk.</p><p id="par0035" class="elsevierStylePara elsevierViewall">As concrete proposals, it is suggested that new documents be created, or existing ones updated, related to the care processes of diseases with an indication for vaccination in which vaccines are included as one of the main elements according to the recommendations of the moment (macro-management). At the same time, the involvement of those in charge of hospital services and departments, and their compliance and monitoring through specific indicators, would promote vaccination (meso-management). Finally, continuing with ongoing across-the-board training in vaccinology among healthcare professionals is essential to promote good practices and the appropriateness of vaccines in immunocompromised patients (micro-management).</p><p id="par0040" class="elsevierStylePara elsevierViewall">Improving the health of this group could be achieved with a simple organisational shift.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreasing influenza vaccine coverage among adults with high-risk chronic diseases in Spain from 2014 to 2017" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Mora-Zamorano" 1 => "V. Hernández-Barrera" 2 => "I. Jiménez-Trujillo" 3 => "J.J. Zamorano-Leon" 4 => "R. Jiménez-García" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/21645515.2019.1646577" "Revista" => array:6 [ "tituloSerie" => "Hum Vaccin Immunother" "fecha" => "2019" "volumen" => "16" "paginaInicial" => "95" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31339794" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conceptos y definiciones básicas de la gestión clínica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Román" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5867/medwave.2012.05.5418" "Revista" => array:4 [ "tituloSerie" => "Medwave." "fecha" => "2012" "volumen" => "12" "numero" => "5" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Estrategia de vacunación frente a COVID19 en España. Actualización 4. Grupo de Trabajo Técnico de Vacunación COVID-19, de la Ponencia de Programa y Registro de Vacunaciones. Ministerio de Sanidad. 2022. Disponible en: <a target="_blank" href="https://www.jcyl.es/junta/cs/COVID-19_Actualizacion4_EstrategiaVacunacion.pdf">https://www.jcyl.es/junta/cs/COVID-19_Actualizacion4_EstrategiaVacunacion.pdf</a>." ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ministerio de Sanidad. Estrategia de vacunación frente a COVID19 en España. Actualización 5. Grupo de Trabajo Técnico de Vacunación COVID-19, de la Ponencia de Programa y Registro de Vacunaciones. Madrid: Ministerio de Sanidad, 2022. Disponible en: <a target="_blank" href="https://www.sanidad.gob.es/profesionales/saludPublica/prevPromocion/vacunaciones/covid19/Actualizaciones_Estrategia_Vacunacion/docs/COVID-19_Actualizacion5_EstrategiaVacunacion.pdf">https://www.sanidad.gob.es/profesionales/saludPublica/prevPromocion/vacunaciones/covid19/Actualizaciones_Estrategia_Vacunacion/docs/COVID-19_Actualizacion5_EstrategiaVacunacion.pdf</a>." ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Astursalud. Portal de salud del Principado de Asturias. Actualización Programas Clave (PCAIS) Asturias. 2017. Disponible en: <a target="_blank" href="https://www.astursalud.es/categorias/-/categorias/profesionales/01000practica-clinica/02000programas-clave-de-atencion-interdisciplinar-y-guias-clinicas/02000actualizacion-programas-clave-pcais-asturias">https://www.astursalud.es/categorias/-/categorias/profesionales/01000practica-clinica/02000programas-clave-de-atencion-interdisciplinar-y-guias-clinicas/02000actualizacion-programas-clave-pcais-asturias</a>." ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Consejería de Salud de la Junta de Andalucía. Guía de diseño y mejora continua de procesos asistenciales. Sevilla: Consejería de Salud, 2001. Disponible en: <a target="_blank" href="https://www.juntadeandalucia.es/export/drupaljda/salud_5af1956c952f3_guia_diseno_primera.pdf">https://www.juntadeandalucia.es/export/drupaljda/salud_5af1956c952f3_guia_diseno_primera.pdf</a>." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/2529993X/0000004100000008/v1_202310130444/S2529993X23001016/v1_202310130444/en/main.assets" "Apartado" => array:4 [ "identificador" => "66012" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/2529993X/0000004100000008/v1_202310130444/S2529993X23001016/v1_202310130444/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X23001016?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 14 | 1 | 15 |
| 2024 September | 27 | 13 | 40 |
| 2024 August | 12 | 11 | 23 |
| 2024 July | 12 | 10 | 22 |
| 2024 June | 7 | 7 | 14 |
| 2024 May | 11 | 6 | 17 |
| 2024 April | 11 | 2 | 13 |
| 2023 October | 3 | 0 | 3 |
