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Los pacientes diabéticos tienen concentraciones de hormona del crecimiento (GH) basales y estimuladas más elevadas que los sujetos normales. Las alteraciones en la secreción de GH no son iguales en los diabéticos tipo 1 y tipo 2. Los diabéticos tipo 1 tienen concentraciones basales de GH más elevadas que los sujetos normales, así como en un aumento de la respuesta secretora ante distintos estímulos. En la diabetes tipo 2 la respuesta de GH ante GHRH en algunos casos se ha encontrado disminuida, tanto en obesos como en delgados, mientras que en otros casos se encuentra una respuesta similar a la de los sujetos normales.
Esta alteración en los valores de GH es más llamativa en los períodos de mal control metabólico. Esta alteración en la secreción de GH se cree que puede estar implicada en el desarrollo de complicaciones agudas y crónicas asociadas a la diabetes.
Palabras clave:
Secreción de hormona del crecimiento
Diabetes mellitus
Control metabólico
Complicaciones crónicas
Diabetic patients have basal and stimulated concentrations of growth hormone (GH) higher than normal controls. These alterations in GH secretion are not the same in type 1 and type 2 diabetic patients. Type 1 diabetic patients have higher basal GH concentrations than normal subjects and augmented GH response to different provocative stimuli. In type 2 diabetic subjects the GH response to GHRH in some cases was reported to be reduced in both lean and obese type 2 diabetics compared with controls while others report a response similar to controls. These elevations in GH levels are more important in the periods of poor metabolic control. Abnormal GH secretion has been suggested as a causative factor in the development of some of the acute and chronic complications of diabetes.
Key words:
Growth hormone secretion
Diabetes mellitus
Metabolic control
Chronic complications
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