Article information
El hiperparatiroidismo inducido por litio es una causa poco frecuente de hipercalcemia. Normalmente es una situación reversible que remite tras suspender el tratamiento, aunque, en un grupo reducido de pacientes, la estimulación continuada de las glándulas paratiroides conlleva la formación de adenomas. Presentamos un caso de hiperparatiroidismo asociado a tratamiento prolongado con litio.
Palabras clave:
Hipercalcemia
Hiperparatiroidismo
Terapia con litio
Adenoma paratiroideo
Lithium-induced primary hyperparathyroidism is an uncommon etiology of hypercalcemia. It is usually reversible after discontinuing treatment. Nevertheless, in a small group of patients, parathyroid continued stimulation induces the formation of adenomas. We report a patient with hyperparathyroidism associated to prolonged lithium therapy.
Key words:
Hypercalcaemia
Hyperparathiroidism
Lithium therapy
Parathyroid adenoma
Full text is only aviable in PDF
Bibliografía
[1.]
G. Celis, M. Fiter, X. Latorre, C. Llevaria.
Oxyphilic parathyroid adenoma and lithium therapy.
Lancet, 352 (1998), pp. 1070
[2.]
H. Abdullah, R. Bliss, A.I. Guinea, L. Delbridge.
Pathology and outcome of surgical treatment for lithium associated hyperparathyroidism.
Br J Surg, 86 (1999), pp. 91-93
[3.]
S.T. Haden, A.L. Stoll, S. McCormick, J. Scott, G. Fuleihan, et al.
Alterations in parathyroid dynamics in lithium-treated subjects.
J Clin Endocrinol Metab, 82 (1997), pp. 2844-2848
[4.]
H. Bendz, I. Sjodin, G. Toss, K. Berglund.
Hyperparathyroidism and longterm lithium therapy a crooss-sectional study and the effect of lithium withdrawal.
J Intern Med, 240 (1996), pp. 357-365
[5.]
T.W. Mark, C.C. Shek, C.C. Chow, Y.K. Wing, S. Lee.
Effects of lithium therapy on bone mineral metabolism: a two-year prospective longitudinal study.
J Clin Endocrinol Metab, 83 (1998), pp. 3857-3859
[6.]
H. Bendz, I. Sjodin, G. Toss, K. Berglund.
Hyperparathyroidism and long term lithium therapy. A cross sectional study and the effect of lithium withdrawal.
J Intern Med, 240 (1996), pp. 357-365
[7.]
J. Nordenstrom, K. Strigard, L. Perbeck, J. Willems, M. Bagedahl-Strindlund, J. Linder.
Hyperparathyroidism associated with treatment of maniacdepressive disorders by lithium.
Eur J Surg, 158 (1992), pp. 207-211
[8.]
L.E. Mallette, K. Khoiuri, H. Zengotita, B.W. Hollis, S. Malini.
Lithium treatment increases intact and midregion parathyroid hormone and parathyroid volume.
J Clin Endocrinol Metab, 68 (1989), pp. 654-660
Copyright © 2002. Sociedad Española de Endocrinología y Nutrición