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"raquel.ssv@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Catalina" "apellidos" => "Riera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Paul" "apellidos" => "Andrade" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Marta" "apellidos" => "Faubel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Otorrinolaringología, Hospital General de Castellón, Castellón, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital General de Castellón, Castellón, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lipofibromatosis cervical en la infancia" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 639 "Ancho" => 1250 "Tamanyo" => 76119 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">NMR coronal and sagittal slice. Ovoid tumour with well defined edges, 47 × 23 × 40 mm, located at subcutaneous cell tissue level, hyperintense in T1 and T2, with no infiltrative component but with adjacent structures displaced.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical case</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 4-year-old girl, with no background of interest, who was referred from paediatrics due to a cervical mass which did not respond to antibiotic treatment.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed an anterior movable cervical tumour of 3 cm, which was not painful on palpation, extending to the sternal notch.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Cervical ultrasound was performed reporting an ovoid tumour of 4.3 × 1.5 cm located in subcutaneous cell tissue compatible with lipoma and a full magnetic resonance test was performed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">An ultrasound-guided core needle biopsy was requested, which reported mature adipose tissue with no signs of malignancy.</p><p id="par0025" class="elsevierStylePara elsevierViewall">With a suspected diagnosis of lipoma we decided to continue with conservative treatment, with a bi-annual medical check-up and annual ultrasound scan.</p><p id="par0030" class="elsevierStylePara elsevierViewall">After three years of slow progressive growth we decided to perform surgery with complete excision of the tumour via cervicotomy.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The surgical specimen extracted presented with an encapsulated appearance of 6 × 4 × 3.5 cm, alternating between yellowish areas next to whitish fibrous regions in appearance. Microscopic analysis reported adipose tissue lobules separated by fibrous septa compatible with lipoblastoma (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Immunohistochemical techniques resulted in: negative actin and CD31, Ki67 under 1% and focally positive CD34. A diagnosis of lipofibromatosis was therefore reached.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">Lipofibromatosis is a rare benign tumour, located in the subcutaneous cell tissue of extremities, although it may also appear in other regions.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">It is usually asymptomatic, with patients consulting over aesthetic deformities or symptoms derived from compression of adjacent structures.</p><p id="par0055" class="elsevierStylePara elsevierViewall">With regard to epidemiology, age of appearance on average is at one year, presenting tumours prior to the age of 3 years in most patients. There is no clear predominance of either sex.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Differential diagnosis should be made with entities such as: fibromatosis, calcifying aponeurotic fibroma, fibrous hamartoma of infancy, lipoblastoma, lipofibromatous hamartoma, lipoma, macrocystic lymphatic malformation, myofibroma and rabdomyosarcoma.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Ultrasound and nuclear magnetic resonance is used for diagnosis, but definitive diagnosis is histological, presenting as a tumour consisting of adipose tissue separated into lobules by fibroblast or myofibroblasts fascicles with immunohistochemical positive testing for CD99 and CD34 in fused cells and S100 in adipocytes.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4–6</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The treatment of choice is complete excision. In cases where there is clinical stability and no invasion of deep tissues, a wait-and-see approach may be used.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of interests</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Clinical case" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflict of interests" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-01-22" "fechaAceptado" => "2020-02-25" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Solavera R, Riera C, Andrade P, Faubel M. Lipofibromatosis cervical en la infancia. Acta Otorrinolaringol Esp. 2021;72:201–202.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 639 "Ancho" => 1250 "Tamanyo" => 76119 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">NMR coronal and sagittal slice. Ovoid tumour with well defined edges, 47 × 23 × 40 mm, located at subcutaneous cell tissue level, hyperintense in T1 and T2, with no infiltrative component but with adjacent structures displaced.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 416 "Ancho" => 1740 "Tamanyo" => 159284 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, nodular tumour, approximately 6 cm diameter. B–D, haematoxylin-eosin staining where abundant adipose tissue is observed formed by mature adiposities and with no atypea, alternated with a fibroblastic component of fusiform cells which form fascicles.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipofibromatosis: an institutional and literature review of an uncommon entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.D. Boos" 1 => "K.R. Chikwava" 2 => "J.P. Dormans" 3 => "N.A. Chauvin" 4 => "M. 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