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Vacunas (English Edition) Monitoring of hepatitis B infection in the elderly population of eastern Iran
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Vol. 26. Issue 1.
(January - March 2025)
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Vol. 26. Issue 1.
(January - March 2025)
Original article
Monitoring of hepatitis B infection in the elderly population of eastern Iran
Monitorización de la infección por hepatitis B en los sujetos mayores de Irán oriental
Abdol Sattar Pagheha, Effat Alemzadeha, Eisa Nazarb, Mitra Moodic, Farshad Sharifid, Ebrahim Miri-Moghaddame, Mohamad Taghi Rahimif, Soroush Mohammadig, Masood Ziaeea,
Corresponding author
dr.m.ziaee@gmail.com

Corresponding author at: Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
a Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
b Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
c Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
d Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
e Cardiovascular Diseases Research Center, Department of Molecular Medicine, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
f Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran
g Department of Medical Biotechnology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
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Tables (5)
Table 1. Evaluation of the relationship between demographic characteristics and the population of elderly individuals under study with the result of the hepatitis B test#.
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Table 2. Comparison of the frequency distribution of underlying diseases of elderly people with the result of hepatitis B test#.
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Table 3. Measurement of the relationship between the health status of elderly individuals and the result of a hepatitis B test#.
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Table 4. Comparison of the mdian values of clinical variables between elderly individuals with results of hepatitis B test#.
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Table 5. Multiple logistic regression model to determine the factors associated with hepatitis B in elderly individuals.
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Abstract
Objectives

This study aimed to investigate the prevalence of HBV infection and its associated risk factors in the elderly in Birjand.

Materials and methods

The present study was a part of the community-based prospective cohort study. Subjects over 60 years of age were assessed using standard questionnaires and blood factors. The samples were tested for HBsAg by enzyme-linked immunosorbent assay.

Results

Of 542 elderly people living in Birjand, 11 cases (2.03%) were positive. The median age of patients with HBsAg positive and negative was 69 (IQR: 63–77) years and 67 (IQR: 63–74) years, respectively. The results of the multiple logistic regression model showed that fatty liver disease was significantly associated with having hepatitis B (AOR (95% CI)=5.50 (1.16, 25.88)) (p<.05). However, there was no significant relationship found between variables age, sex, marital status, years of study, underlying diseases, body mass index, smoking, and blood factors with having hepatitis B (p>.05).

Conclusions

Even though there were only a few positive cases, leading to a non-significant report, it is crucial to emphasize the clinical significance and health and well-being of elderly individuals contracting hepatitis B. This information can be valuable in devising suitable disease management strategies for this age group.

Keywords:
Hepatitis B
Elderly
Hepatitis B surface antigen
Prevalence
Iran
Resumen
Objetivos

El objetivo de este estudio fue investigar la prevalencia de la infección por VHB y sus factores de riesgo asociados en las personas mayores de Birjand.

Materiales y Métodos

Dicho estudio formó parte de un estudio de cohorte prospectivo de base comunitaria. Se evaluaron los sujetos mayores de 60 años utilizando cuestionarios estándar y factores sanguíneos. Se estudió el HBsAg mediante ensayo de inmunoadsorción ligado a enzima (ELISA).

Resultados

De las 542 personas mayores residentes en Birjand, 11 casos (2,03%) resultaron positivos. La edad media de los pacientes con HBsAg positivo y negativo fue de 69 (RIC: 63–77) años y 67 (RIC: 63–74) años, respectivamente. Los resultados del modelo de regresión logística múltiple reflejaron que la enfermedad de hígado graso estaba significativamente asociada a la tenencia de hepatitis B (AOR (95% IC) = 5,50 (1,16, 25,88)) (P < 0,05). Sin embargo, no se observó relación significativa entre las variables de edad, sexo, estado civil, años de estudio, enfermedades subyacentes, índice de masa corporal, tabaquismo, y factores sanguíneos y la tenencia de hepatitis B (P > 0,05).

Conclusiones

Aun cuando existieron pocos casos positivos, conducentes a un informe no significativo, es esencial desatacar la significación clínica y la salud y el bienestar de las personas mayores que contraen hepatitis B. Esta información puede ser valiosa a la hora de diseñar estrategias de gestión de enfermedades para este grupo de edad.

Palabras clave:
Hepatitis B
mayores
antígeno de superficie de la Hepatitis B
prevalencia
Irán

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