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Inicio Neurología (English Edition) Refractory neuralgia of the superior laryngeal nerve: A case study
Información de la revista
Vol. 31. Núm. 5.
Páginas 344-345 (junio 2016)
Vol. 31. Núm. 5.
Páginas 344-345 (junio 2016)
Letter to the Editor
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Refractory neuralgia of the superior laryngeal nerve: A case study
Neuralgia del nervio laríngeo superior: a propósito de un caso de difícil control
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C. Rodríguez-Martín, C. de la Cruz Rodríguez, M. Ruiz Piñero, Á.L. Guerrero Peral
Autor para correspondencia
gueneurol@gmail.com

Corresponding author.
Servicio de Neurología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
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Dear Editor:

Superior laryngeal neuralgia is a rare entity first described in 1900 by Avellis.1 It is characterised by severe pain in the lateral aspect of the throat, the submaxillary region, and/or under the ear.

From an anatomical point of view, the superior laryngeal nerve branches off the vagus nerve and descends to the larynx along with the carotid artery. At some point in its trajectory, the superior laryngeal nerve divides into an external and an internal branch.2 The external branch of the superior laryngeal nerve is essentially motor, while the internal branch provides sensory innervation. The internal branch penetrates the thyrohyoid membrane and innervates the base of the tongue, the epiglottis, and the mucous membrane of the larynx.3

Here we present the case of a patient with idiopathic superior laryngeal neuralgia whose symptoms were especially difficult to manage.

The patient was a 61-year-old man with no relevant medical history who presented at the headache unit due to a 6-month history of pain, characterised by paroxysms of severe stabbing pain (9 out of 10 on the visual analogue scale [VAS]; 0=no pain, and 10=worst pain imaginable) irradiating from the right side of the neck to the submandibular area and below the ipsilateral ear. Paroxysms lasted between 30seconds and 1minute and were triggered by swallowing and straining his voice. During the neurological examination, pain upon palpation of the right thyrohyoid membrane was observed. The otorhinolaryngological examination and the imaging tests (cranial MRI and cervical CT) revealed no alterations.

Pharmacological treatment with carbamazepine at 500mg/day was initiated but the patient showed no response. He was subsequently treated with lamotrigine (100mg/day) and pregabalin (150mg/day), but no improvement was seen. Ultimately, lacosamide at a dose of 150mg/day achieved almost complete pain control.

The causes of superior laryngeal neuralgia can be classified as either central or peripheral. Pain worsened by swallowing is thought to be due to central causes. Peripheral causes include scarring from carotid artery surgery,4 deviation of the hyoid bone,5 amygdalectomy,6 lateral pharyngeal diverticulum,7 or trauma8. None of these findings or relevant history were present in our patient.

Patients must respond to a local anaesthetic block to be diagnosed with superior laryngeal neuralgia according to the criteria of the second edition of the International Classification of Headache Disorders (ICHD-2) (code 13.4).9 However, we did not perform this procedure in our patient due to its technical complexity and the large amount of anaesthetic it requires. Other authors indicate anaesthetic block only for cases refractory to medical treatment. Besides this, the high dose of local anaesthetics involved may cause wallerian degeneration with Schwann cell damage and axonal dystrophy.10 Despite the lack of an analysis of our patient's response to anaesthetic block, his clinical symptoms and the identification of a trigger in the thyrohyoid membrane supported the diagnosis of superior laryngeal neuralgia.

The differential diagnosis of superior laryngeal neuralgia includes such underlying structural conditions as inflammatory processes of the larynx and laryngeal neoplasms.11 In our case, these conditions were ruled out after an otorhinolaryngological examination. Neuralgia of other peripheral nerves differs from superior laryngeal neuralgia in the location of pain and trigger points. Carotidynia resembles superior laryngeal neuralgia in that it is characterised by throbbing pain in the anterior cervical region which may be accompanied by migraine-like headache.12 Palpating over the carotid bifurcation induces pain and helps distinguish between the 2 entities.

Superior laryngeal neuralgia is an uncommon condition that requires prompt treatment; early identification and management may avoid unnecessary procedures.13 Control of neuropathic pain can be difficult on occasions. Among antiepileptics, also called neuromodulators, lacosamide has a novel action mechanism which enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation. This, combined with its high oral bioavailability, low plasma protein binding, and minor pharmacological interactions,14 makes lacosamide an option to consider in the management of neuralgia.15 In our patient, the use of this drug was decisive.

In summary, a diagnosis of superior laryngeal neuralgia should be considered in patients with unilateral paroxysmal pain in the lateral aspect of the neck and the ipsilateral ear. Lacosamide may be a good option in refractory patients before resorting to more invasive techniques such as anaesthetic block.

References
[1]
G. Avellis.
Typische forms von Kehlkopneuralgie.
Munch Med Wochenschr, 47 (1900), pp. 1592-1594
[2]
D.D. Berlin, F.H. Lahey.
Dissections of the recurrent and superior laryngeal nerves. The relation of the recurrent to the inferior thyroid artery and the relation of the superior to abductor paralysis.
Surg Gynecol Obst, 49 (1929), pp. 102-104
[3]
C.F. Durham, T.S. Harrison.
The surgical anatomy of the superior laryngeal nerve.
Surg Gynecol Obst, 118 (1964), pp. 38-44
[4]
B.P. O’Neill, A.E. Aronson, B.W. Pearson, L.A. Nauss.
Superior laryngeal neuralgia: carotidynia or just another pain in the neck?.
Headache, 22 (1982), pp. 6-9
[5]
S. Kodama, K. Oribe, M. Suzuki.
Superior laryngeal neuralgia associated with deviation of the hyoid bone.
Auris Nasus Larynx, 35 (2008), pp. 429-431
[6]
G.W. Bruyn.
Superior laryngeal neuralgia.
Cephalalgia, 3 (1983), pp. 235-240
[7]
A. Bagatzounis, G. Geyer.
Lateral pharyngeal diverticulum as a cause of superior laryngeal nerve neuralgia.
Laryngorhinootologie, 73 (1994), pp. 219-221
[8]
W.F. Baxter.
Post-traumatic superior laryngeal neuralgia.
Calif Med, 88 (1958), pp. 235-239
[9]
Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders.
Cephalalgia, 24 (2004), pp. S1-S152
[10]
R.F. Baugh, A. Baugh, F. Bunge.
Superior laryngeal nerve syndrome and the evaluation of anterior neck pain.
Am J Otolaryngol, 33 (2012), pp. 481-483
[11]
K. Takahashi Sato, M. Suzuki, A. Izuha, S. Hayashi, T. Isosu, M. Murakawa.
Two cases of idiopathic superior laryngeal neuralgia treated by superior laryngeal nerve block with a high concentration of lidocaine.
J Clin Anesth, 19 (2007), pp. 237-238
[12]
D.M. Roseman.
Carotidynia. A distinct syndrome.
Arch Otolaryngol, 85 (1967), pp. 81-84
[13]
D. Schimidt, I. Strutz.
Superior laryngeal neuralgia.
J Neurol, 225 (1981), pp. 223-225
[14]
G. McCleane.
Lacosamide for pain.
Expert Opin Investig Drugs, 19 (2010), pp. 1129-1134
[15]
P.E. Bermejo, L. Alba-Alcantara.
Eficacia de la lacosamida en el tratamiento del dolor neuropático.
Rev Neurol, 56 (2013), pp. 188-190

Partially presented in poster format at the 65th Annual Meeting of the Spanish Society of Neurology, Barcelona, November 2013.

Please cite this article as: Rodríguez-Martín C, de la Cruz Rodríguez C, Ruiz Piñero M, Guerrero Peral ÁL. Neuralgia del nervio laríngeo superior: a propósito de un caso de difícil control. Neurología. 2016;31:344–345.

Copyright © 2014. Sociedad Española de Neurología
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