Información del artículo
Las neoplasias y el hiperparatiroidismo primario son las causas más frecuentes de hipercalcemia y comprenden el 90% de éstas. Hace casi medio siglo que se describió el síndrome de la hipercalcemia humoral tumoral y 15 años que se identificó su agente etiológico, la proteína relacionada con la paratirina (PTHrP), y se introdujo su medida en la práctica clínica y de investigación. El desarrollo de la hipercalcemia humoral tumoral constituye un signo de mal pronóstico. Disponemos de nuevos y potentes fármacos hipocalcemiantes (fundamentalmente bifosfonatos) para el tratamiento de estas situaciones, lo que permite a los pacientes mejorar su calidad de vida en fases a menudo terminales de la enfermedad.
Palabras claves:
Hipercalcemia
Hiperparatiroidismo primario
Cáncer
Bifosfonato
Malignancy and primary hyperparathyroidism are the most common causes of hypercalcemia, accounting for more than 90% of hypercalcemic patients. It has been half a century since humoral hypercalcemia of malignancy was first described and fifteen years since its etiological agent (PTHrP) was identified and introduced into medical and research activities. Humoral hypercalcemia of malignancy appears to be an ominous prognostic sign. New and potent anti-hypercalcemic agents (mainly bisphosphonates) are available to treat these situations allowing the patients to be in less discomfort during the terminal stage of their illness.
Key words:
Hypercalcemia
Primary hyperparathyroidism
Malignancy
Bisphosphonate
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