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Archivos de la Sociedad Española de Oftalmología (English Edition) Uveitis associated with immunotherapy and its response to monotherapy with diflu...
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Vol. 100. Issue 12.
Pages 788-792 (December 2025)
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Vol. 100. Issue 12.
Pages 788-792 (December 2025)
Clinical Case
Uveitis associated with immunotherapy and its response to monotherapy with difluprednate: A case report
Uveítis asociada a inmunoterapia y su respuesta a monoterapia con difluprednato, a propósito de un caso
C.M. Ortega, A.T. Pérez Bello
Corresponding author
atatianapb@gmail.com

Corresponding author.
, B.F. Graizman Kohan, M.D. Eraso Quintero, J. Stuart Pennington, F.M. Preto
Centro de Ojos Lomas, Lomas de Zamora, Provincia de Buenos Aires, Argentina
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Abstract

Nivolumab and ipilimumab are immune checkpoint inhibitors widely used for the treatment of metastatic melanoma. They can cause various adverse effects in a significant percentage of treated patients, including uveitis. Symptoms include decreased visual acuity, pain, redness, and photophobia, which typically resolve with appropriate anti-inflammatory therapy. The aim of this work is to report a case of uveitis in a patient on ipilimumab and nivolumab for the treatment of metastatic melanoma, as well as the response to therapy with difluprednate.

Keywords:
Uveitis
Immune checkpoint inhibitors
Ipilimumab
Nivolumab
Difluprednate
Resumen

El nivolumab y el ipilimumab son inhibidores de puntos de control inmunitario ampliamente utilizados para el tratamiento del melanoma metastásico. Pueden generar diferentes efectos adversos en un porcentaje importante de los pacientes tratados, entre estos, la uveítis. Los síntomas son disminución de la agudeza visual, dolor, enrojecimiento y fotofobia, que suelen resolver con terapia antiinflamatoria. El objetivo del presente trabajo es reportar un caso de uveítis en una paciente que recibió tratamiento con ipilimumab y nivolumab para manejo de melanoma metastásico y su respuesta a la terapia con difluprednato.

Palabras clave:
Uveítis
Inhibidores de puntos de control inmunitario
Ipilimumab
Nivolumab
Difluprednato

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