P-116 PREDICTION OF CIRRHOSIS THROUGH THE VELOCITY TIME INTEGRAL OF PORTAL VEIN TRACE

Conflict of interest

No

Introduction and Objectives

Doppler ultrasound of the portal vein (PV) is a routine study in the diagnosis and follow-up of cirrhotic patients. Identifying non-invasive parameters for the diagnosis and monitoring of this population is crucial. The assessment of the velocity time integral (VTI) is a widely used parameter in doppler ultrasound (cardiology) but has been less explored in the context of portal doppler.

Patients / Materials and Methods

Portal doppler ultrasound was performed on a cohort of patients with cirrhosis and controls. Several hemodynamics variables of the PV and hepatic artery (HA) were collected (Table 1). Logistic regression was used to determine the predictive capacity of these variables. A ROC curve was generated, and the area under the curve (AUC) was calculated. Sensitivity, specificity, NPV, PPV, and likelihood ratios (LLR+ and LLR-) were also evaluated.

Results and Discussion

Fifty patients were evaluated (36 with cirrhosis and 14 controls). Differences between variables of cirrhosis and control groups are shown in Table 1. The optimal cutoff point for VTI Porta x min was 1517.3 cm/min, with a sensitivity of 88.89%, specificity of 83.33%, NPV of 83.33%, PPV of 88.89%, LLR+ of 5.33, and LLR- of 0.13. The area under the ROC curve was 0.91.

Conclusions

VTI Porta x min is a significant predictor of hepatic cirrhosis. This measure can be a valuable tool in clinical practice to identify patients with a high probability of cirrhosis and may be part of a multiparametric liver evaluation.

Tabla 1

Variable	Cirrosis	Controles	p
VTI portal x minute (cm x min)	1291.3 (976.8 - 1558.9)	2514.3 (2152.5 - 2670.6)	<0.001*
Total portal volume	1421.9 (1100.7 - 1874.2)	1688.3 (1399.8 - 2881.13)	0.098
VTI HA x beat (cm x beat)	52 (41.4- 65.9)	42 (33- 56.1)	0.160
VTI HA x min (cm x min)	3381.3 (2642.1 - 4087.2)	3265(2327- 4012.9)	0.552
Total HA volume	791.2(282.6- 1189)	257.2 (151.4 - 371.5)	0.001*
Total liver flow	2314.16 (1603.5 - 3115.8)	1968.09 (1650.6 - 3236.1)	0.770
% Portal volume	0.61 (0.5 - 0.8)	0.88 (0.8 - 0.9)	<0.001*
% Arterial volume	0.39 (0.1 - 0.4)	0.12 (0.08-0.1)	<0.001*

Mann-Whitney test, p value < 0,05 statistical significance. HA: Hepatic Artery. VTI: Velocity Integral Time.

VTI V. Porta x min

Curva ROC