Abstracts of the 2025 Annual Meeting of the ALEH
More infoThe Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation of liver imaging in patients at risk of hepatocellular carcinoma (HCC). However, its correlation with histopathological parameters has not been sufficiently validated in Latin American settings.
To evaluate the correlation between LI-RADS classification assigned through contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) and histopathological findings in patients with suspected hepatocellular carcinoma treated at Fundación Santa Fe de Bogotá.
Materials and MethodsA retrospective observational study was conducted in patients with histologically confirmed HCC and at least one contrast-enhanced imaging study available for blinded review. Clinical, radiological, and histopathological variables were collected. The correlation between LI-RADS category and tumor differentiation grade (Edmondson-Steiner scale) was evaluated using the chi-square test. Statistical analysis was performed with SPSS v25, and a p-value < 0.05 was considered statistically significant.
ResultsA total of 154 patients were included, with a mean age of 64.4 years (95% CI: 63.3–65.4) and a male predominance (65%). Most patients were classified as Child-Pugh A or B and had solitary tumors ≤3 cm. No statistically significant association was found between the LI-RADS category and Edmondson-Steiner grade (Chi2 = 18.77, p = 0.537). Histological grading was heterogeneously distributed within LI-RADS categories 4 and 5, with no clear predominance of poorly differentiated tumors.
ConclusionsIn this cohort, LI-RADS classification did not show a significant correlation with histological differentiation of HCC. Although LI-RADS remains a useful non-invasive diagnostic tool, it should not be used in isolation to infer tumor aggressiveness. Further studies with greater statistical power are required to validate its use as a predictor of tumor histology in Latin American clinical contexts.
