Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Tumor markers and 18F-FDG PET/CT after orchiectomy in seminoma: Is there any cor...
Journal Information
Vol. 40. Issue 5.
Pages 287-292 (September - October 2021)
Share
Share
Download PDF
More article options
Vol. 40. Issue 5.
Pages 287-292 (September - October 2021)
Original Article
Tumor markers and 18F-FDG PET/CT after orchiectomy in seminoma: Is there any correlation?
Marcadores tumorales y 18F-FDG PET/CT después de orquiectomía en seminoma: ¿hay alguna correlación?
Francesco Dondi
Corresponding author
f.dondi@outlook.com

Corresponding author.
, Domenico Albano, Francesco Bertagna, Raffaele Giubbini
Nuclear Medicine, University of Brescia, Spedali Civili Brescia, Brescia, Italy
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (4)
Table 1. The main features of our 41 patients.
Table 2. Correlation between PET/CT results and the main clinical features.
Table 3. Correlation between mean semiquantitative parameters and serum markers.
Table 4. ROC curves analysis for each tumor marker.
Show moreShow less
Abstract
Objective

The aim of our study was to analyze the potential relationship between tumor markers and 18F-fluorodoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) results in patients affected by seminoma.

Material and methods

65 18F-FDG PET/CT scans of 41 patients with diagnosis of seminoma were analyzed and compared to alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG). PET/CT studies were analyzed qualitatively and measuring the maximum and mean standardized uptake value body weight max (SUVbwmax, SUVbwmean), maximum SUV lean body mass (SUVlbm), maximum SUV body surface area (SUVbsa), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of hypermetabolic lesions. All values were compared with serum markers.

Results

31 PET/CT studies were true negative, 28 true positive, 6 false positive and 0 false negative with sensitivity of 100%, specificity of 84%, negative predictive value of 100%, positive predictive value of 82% and accuracy of 91%. No correlation between PET results and tumor marker levels was found and also between AFP and PET/CT semiquantitive parameters. All semiquantitative PET parameters were significantly related to hCG level.

Conclusions

18F-FDG PET/CT has good accuracy in evaluating patients with relapsed seminoma. HCG levels were significantly correlated with metabolic PET/CT parameters.

Keywords:
PET/CT
Seminoma
Tumor markers
Alpha-fetoprotein
Human chorionic gonadotropin
Resumen
Objetivo

El objetivo de nuestro estudio fue analizar la posible relación entre los marcadores tumorales y los resultados de la tomografía por emisión de positrones con 18F-fluorodoxiglucosa/tomografia computarizada (18F-FDG PET/CT) en pacientes afectados por seminoma.

Material y método

se analizaron 65 exploraciones PET/TC 18F-FDG de 41 pacientes con diagnóstico de seminoma y se compararon con alfafetoproteína (AFP) y gonadotropina coriónica humana (hCG). Los estudios PET/CT se analizaron cualitativamente y midieron el valor máximo y medio de la captacion estandarizada de peso corporal maximo (SUVbwmax, SUVbwmean), masa corporal magra SUV maxima (SUVlbm), área de superficie corporal máxima de SUV (SUVbsa), volumen tumoral metabólico (MTV) y glucólisis de lesión total (TLG) de lesiones hipermetabolicas. Todos los valores se compararon con marcadores sericos.

Resultados

31 estudios PET/CT fueron verdaderos negativos, 28 verdaderos positivos, 6 falsos positivos y 0 falsos negativos con sensibilidad del 100%, especificidad del 84%, valor predictivo negativo del 100%, valor predictivo positivo del 82% y precision de 91%. No se encontro correlación entre los resultados de PET y los niveles de marcadores tumorales y tampoco entre los parámetros semicuantitativos de AFP y PET/CT. Todos los parámetros semicuantitativos de PET se relacionaron significativamente con el nivel de hCG.

Conclusiones

18F-FDG PET/CT tiene buena precisión en la evaluación de pacientes con seminoma recidivante. Los niveles de HCG se correlacionaron significativamente con los parametros metabolicos de PET/CT.

Palabras clave:
PET/CT, Seminoma, Marcadores tumorales, Alfafetoproteína, Gonadotropina coriónica humana

Article

These are the options to access the full texts of the publication Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.remnie.2020.06.013
No mostrar más