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Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Role and applications of 18F-FDG PET/CT in the assessment of osteoarticular infe...
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Vol. 44. Issue 1.
(January - February 2025)
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Vol. 44. Issue 1.
(January - February 2025)
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Role and applications of 18F-FDG PET/CT in the assessment of osteoarticular infection and inflammation — Part I

Papel y aplicaciones de la 18F-FDG PET/TC en la evaluación de la infección e inflamación osteoarticular - Parte I
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E. Noriega-Álvareza,b,
Corresponding author
edelnoriega@gmail.com

Corresponding author.
, B. Rodríguez Alfonsoc,b, J.J. Rosales Castillod,b, A. Moreno Ballesterose,b, E. López Rodríguezf,b, S. Sanz Viedmaf,b, M. del P. Orduña Diezg,b, L. Domínguez Gadeah,b
a Servicio de Medicina Nuclear, Hospital Universitario de Guadalajara, Guadalajara, Spain
b Grupo de Patología Músculo-Esquelética de la SEMNIM, Spain
c Servicio de Medicina Nuclear, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
d Servicio de Medicina Nuclear, Clínica Universidad de Navarra, Pamplona, Navarra, Spain
e Servicio de Medicina Nuclear, Hospital Universitario Juan Ramón Jiménez, Huelva, Spain
f Servicio de Medicina Nuclear, Hospital Universitario Virgen de la Victoria, Málaga, Spain
g Servicio de Medicina Nuclear, Hospital Universitario Ramón y Cajal, Madrid, Spain
h Servicio de Medicina Nuclear, Hospital Universitario La Paz, Madrid, Spain
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Abstract

18F-FDG PET/CT has been positioned over time as a useful tool in the evaluation of osteoarticular infections, overcoming conventional explorations like MRI or bone scintigraphy in some indications. Its ability to provide functional and anatomical images simultaneously and its excellent resolution contributes to a more precise and personalised approach in the treatment of osteoarticular diseases such as spondylodiscitis. In addition, it has proven valuable in patients with suspected infection that is complex to diagnose or treat, improving detection in subclinical stages. However, some limitations have been identified, such as difficulty in the differential diagnosis of infection vs. inflammation (as in diabetic foot) or in the interpretation of patients with osteosynthesis materials. In this manuscript, we present a brief review providing general and practical information about the role of 18F-FDG PET/CT in infectious osteoarticular pathology, while part 2 discusses the role of 18F-FDG PET/CT in osteoarticular inflammation.

Keywords:
18F-FDG PET/CT
Osteoarticular infection
Spondylodiscitis
Osteomyelitis
Diabetic foot
Periprosthetic infection
Resumen

La 18F-FDG PET/TC se ha ido posicionando en el tiempo como una herramienta útil en la evaluación de infecciones osteoarticulares, superando en algunas indicaciones, a técnicas convencionales como la resonancia magnética o la gammagrafía ósea. Su capacidad para proporcionar imágenes funcionales y anatómicas simultáneamente y su excelente resolución, contribuye a un abordaje más preciso y personalizado en el tratamiento de las enfermedades osteoarticulares como la espondilodiscitis. Además, ha demostrado ser valioso en pacientes con sospecha de infección compleja, mejorando su detección en fases subclínicas. No obstante, existen algunas limitaciones, como la dificultad en el diagnóstico diferencial infección vs inflamación (como en pie diabético) o en la interpretación de pacientes con materiales de osteosíntesis. En este manuscrito, presentamos una breve revisión proporcionando información general y práctica acerca del papel de la 18F-FDG PET/TC en la patología osteoarticular infecciosa, mientras que en la parte 2 se aborda dicho papel en la inflamación osteoarticular.

Palabras clave:
18F-FDG PET/TC
Infección osteoarticular
Espondilodiscitis
Osteomielitis
Pie diabético
Infección periprotésica

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