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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Intense FDG uptake on PET/CT in the upper and lower respiratory system indicativ...
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Vol. 33. Issue 1.
Pages 32-35 (January - February 2014)
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Vol. 33. Issue 1.
Pages 32-35 (January - February 2014)
Clinical note
Intense FDG uptake on PET/CT in the upper and lower respiratory system indicative of Wegener's granulomatosis
Captación intensa de FDG en una PET/TC del tracto respiratorio superior e inferior indicativa de granulomatosis de Wegener
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M. Aydina,?
Corresponding author
, M.E. Akkoyunlub, F. Yakarb, N. Ergula, M. Sezerb
a Department of Nuclear Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
b Department of Chest Diseases, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
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Abstract

Wegener's granulomatosis (WG) is an uncommon systemic vasculitis, which involves the upper and lower respiratory tracts and the kidneys. Because the patients generally present with clinical manifestations that are similar to common diseases, WG may be initially misdiagnosed as infection or malignancy. We report the case of a 55-year-old male presenting with weight loss, cough, hemoptysis, low-grade fever, and pulmonary nodules detected on the thoracic CT scan. Malignancy was initially suspected, so a PET/CT was performed. It demonstrated intense FDG uptake in the upper and lower respiratory system. The diagnosis of WG was based on PET findings, elevated serum levels of inflammatory markers, and the presence of c-ANCA. We consider that the knowledge of FDG-PET/CT findings may help to make an easier and earlier diagnosis of WG.

Keywords:
FDG
PET/CT
Wegener's granulomatosis
Resumen

La granulomatosis de Wegener (GW) es una vasculitis sistémica poco común que afecta principalmente a las vías respiratorias superiores e inferiores y a los riñones. Debido a que los pacientes generalmente se presentan con manifestaciones clínicas similares a las enfermedades comunes, la GW puede ser confundida inicialmente como una infección o una neoplasia. Se presenta un varón de 55 años de edad con pérdida de peso, tos, hemoptisis, febrícula y nódulos pulmonares detectados en una TC torácica. Inicialmente, se sospechó un proceso maligno, por lo que se realizó una PET/TC que identificó una intensa captación de FDG en las vías respiratorias superiores e inferiores. El diagnóstico de GW se basó en los hallazgos de la PET/TC, los niveles séricos elevados de marcadores inflamatorios y la presencia de c-ANCA. Pensamos que el conocimiento de los hallazgos FDG-PET/TC ayuda a realizar un diagnóstico fácil y precoz de la GW.

Palabras clave:
FDG
PET/TC
Granulomatosis de Wegener

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