Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) A different scintigraphic approach to evaluate the glomerular filtration rate
Journal Information
Vol. 36. Issue 5.
Pages 275-284 (September - October 2017)
Share
Share
Download PDF
More article options
ePub
Visits
0
Vol. 36. Issue 5.
Pages 275-284 (September - October 2017)
Original article
A different scintigraphic approach to evaluate the glomerular filtration rate
Una técnica gammagráfica diferente para evaluar la tasa de filtración glomerular
Visits
...
T. Haciosmanoglua, A.O. Karacalioglua, T. Eyiletenb, S. Incea,
Corresponding author
drsemra@gmail.com

Corresponding author.
, N. Arslana
a Department of Nuclear Medicine, Gulhane Training and Research Hospital, Etlik-Ankara, Turkey
b Department of Nephrology, Gulhane Training and Research Hospital, Etlik-Ankara, Turkey
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (6)
Show moreShow less
Tables (3)
Table 1. Demographic, biochemical and scintigraphic data of the patients.
Table 2. GFR results derived from different formulas.
Table 3. Results of the statistical analysis of pairwise comparisons.
Show moreShow less
Abstract
Objective

Multiple nuclear medicine techniques for measuring renal glomerular filtration rate (GFR) are available but some of them are not practical in daily routine use and others have some accuracy issues. Hence the aim of the study was to design a new camera-based approach to measure the GFR and to compare our results with other measured GFR (mGFR) and estimated GFRs (eGFRs) derived from available measurements and equations used in daily clinical practice.

Material and methods

34 patients were included in the study. ∼74MBq (2mCi) Technetium 99m diethylene-triamine-pentaacetic acid (99mTc-DTPA) was administered to the patients during 5min. A simple formula based on a dilution principle was used to measure GFR (ScinGFR).

Results

Our formula provided similar mGFR results in narrower range as creatinine clearance did and our results correlated well with results derived from other equations. When ScinGFR values were compared to others, there was a significant difference among them (p=0.031) due to difference between the ScinGFR and Cockroft–Gault. When the results of the ScinGFR compared to others without Cockroft-Gault, the difference among them was not significant (p=0.164).

Conclusion

A simple formula considering the extracellular fluid volume was used to predict the split and global kidney functions and despite some discrepancies, good correlation among our results and those derived from available formulas was detected.

Keywords:
99mTc-DTPA
Scintigraphy
Glomerular filtration rate
Renal function
Resumen
Objetivo

Existen múltiples técnicas de medicina nuclear disponibles para medir la tasa de filtración glomerular (GFR), aunque algunas de ellas no resultan muy útiles en la rutina diaria, y otras no son muy precisas. Por tanto, el objetivo de este estudio fue diseñar una nueva técnica basada en el uso de una cámara para medir la GFR y comparar nuestros resultados con otras mediciones de GFR (mGFR) y estimaciones de GFR (eGFRs), derivadas de las mediciones disponibles y las ecuaciones utilizadas en la práctica clínica diaria.

Material y métodos

Se incluyó en el estudio a 34 pacientes. Se infundió alrededor de 74MBq (2mCi) de 99mTc-ácido dietilen-triamin-pentaacético (99mTc-DTPA) a los pacientes durante 5min. Se utilizó una fórmula simple, basada en un principio de disolución, para medir la GFR (ScinGFR).

Resultados

Nuestra fórmula aportó resultados similares de mGFR en el rango más estrecho logrado por la depuración de creatinina, guardando una correlación muy positiva con los resultados derivados de otras ecuaciones. Al comparar los valores de ScinGFR con otros valores, se produjo una diferencia estadísticamente significativa entre ellos (p=0.031), debido a la diferencia entre ScinGFR y Cockroft–Gault. Al comparar los resultados de ScinGFR con otros valores, sin considerar Cockroft-Gault, la diferencia entre ellos fue estadísticamente significativa (p=0.164)

Conclusión

Se utilizó una fórmula simple considerando el volumen de líquido extracelular, para predecir las funciones globales e individuales renales y, a pesar de ciertas discrepancias, se detectó una buena correlación entre nuestros resultados y aquellos derivados de las fórmulas disponibles.

Palabras clave:
99mTc-DTPA
Gammagrafía
Tasa de filtración glomerular
Función renal

Article

These are the options to access the full texts of the publication Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos