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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 68Ga-DOTANOC PET/CT detection of multiple extracranial localizations in a patien...
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Vol. 34. Issue 4.
Pages 258-260 (July - August 2015)
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Vol. 34. Issue 4.
Pages 258-260 (July - August 2015)
Clinical note
68Ga-DOTANOC PET/CT detection of multiple extracranial localizations in a patient with anaplastic meningioma
Uso de 68Ga-DOTANOC PET/TC en la detección de localizaciones extracraneales múltiples en un paciente con meningioma anaplásico
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A. Golemia, A. Ambrosinib, P. Cecchic, A. Ruiud, S. Chondrogiannise, M. Farsada, D. Rubelloe,
Corresponding author
a Division of Nuclear Medicine, Central Hospital, Bolzano, Italy
b Division of Pathology, Central Hospital, Bolzano, Italy
c Division of Neurosurgery, Central Hospital, Bolzano, Italy
d Division of Radiology, Central Hospital, Bolzano, Italy
e Department of Nuclear Medicine & PET/CT Centre, Santa Maria della Misericordia Hospital, Rovigo, Italy
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Abstract

We report herein a case of a 65-year-old male with intracranial recurrence of atypical meningioma initially treated with a combination of surgical resection and gamma knife radiotherapy. Afterwards, he underwent a 68Ga-DOTANOC PET/CT scan in order to evaluate the feasibility of peptide receptor radionuclide therapy (PRRT). The scan identified multiple pulmonary, pleural and lymph node localizations. Histological diagnosis was consistent with intracranial atypical meningioma with diffuse metastatic spread. In our case, we have shown that meningioma with extracranial locations may present high uptake of somatostatin receptor analogues. Among other radionuclides, we believe that 68Ga-DOTANOC PET/CT may be particularly useful for staging, detection of recurrence, evaluation of disease extension and alternative therapeutic approaches.

Keywords:
68Ga-DOTANOC PET/CT
Atypical meningioma
Distant localizations
Resumen

Presentamos el caso de un varón de 65 años de edad, con recurrencia intracraneal de meningioma atípico tratada inicialmente con una combinación de resección quirúrgica y radioterapia bisturí de rayos gamma. Después se sometió a una exploración 68Ga-DOTANOC PET/TC con el fin de evaluar la viabilidad de la terapia metabólica con el receptor del péptido (PRRT). Se identificaron múltiples localizaciones en pulmón, pleura y ganglios linfáticos. El diagnóstico histológico fue compatible con meningioma atípico intracraneal y diseminación metastásica difusa. Se ha demostrado con nuestro caso que meningioma con localizaciones extracraneales puede presentar alta captación de análogos de los receptores de somatostatina. Entre otros radiotrazadores creemos que 68Ga-DOTANOC PET/TC puede ser particularmente útil en la estadificación, detección de la recurrencia, la evaluación de la extensión de la enfermedad y los enfoques terapéuticos alternativos.

Palabras clave:
68Ga-DOTANOC PET/TC
Meningioma atípico
Localizaciones distantes

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