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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 18F-FDG-PET/CT in lymphoma: Two decades of experience
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Vol. 31. Issue 6.
Pages 340-349 (November - December 2012)
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Vol. 31. Issue 6.
Pages 340-349 (November - December 2012)
Continuing education
DOI: 10.1016/j.remnie.2012.09.004
18F-FDG-PET/CT in lymphoma: Two decades of experience
18F-FDG-PET/TC en linfoma: dos décadas de experiencia
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A.M. Álvarez Páez??
Corresponding author
, J.M. Nogueiras Alonso, A. Serena Puig
Servicio de Medicina Nuclear, Complejo Hospitalario Universitario de Vigo, Hospital Meixoeiro, Vigo, Spain
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Tables (5)
Table 1. The WHO classification of lymphomas (Jaffe11).
Table 2. The uptake of 18F-FDG-PET/CT of the different subtypes of lymphoma.
Table 3. Ann Arbor classification (Cotswolds modification) for the staging of lymphomas.
Table 4. Evaluation of the type of lymphoma response for clinical trials.
Table 5. London scale—First International Workshop on PET 2011.
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Abstract

The use of 18F-FDG-PET/CT has changed the management of patients with lymphoma for the last two decades. This technique improves initial staging of the disease, making a prognostic approach and appropriate treatment planning, as well as monitoring therapy response of lymphoma. However, there are still controversial issues in medical literature that impact on daily clinical practice. This comprehensive literature review summarizes the current information regarding the potential use of 18F-FDG-PET/CT in patients with lymphoma, highlighting the main applications and the current dilemmas for the nuclear medicine physicians at the time of the evaluation of these studies, trying to standardize criteria for its assessment, particularly in restaging and therapy monitoring.

Keywords:
Lymphoma
Positron emission tomography
PET/CT
SUV
Contrast-enhanced PET/CT
Prognosis
Abbreviations:
ABVD
BEACOPP
NK cells
REAL classification
HD
MCL
FL
NHL
DLBCL
MRU
NCCN
WHO
ChT
R-CHOP
RDT
CT
EBV
HCC
HIV
Resumen

El uso del 18F-FDG-PET/TC ha introducido cambios relevantes en el manejo de los pacientes con linfoma en las últimas dos décadas. Esta técnica de imagen funcional permite mejorar la estadificación inicial de la enfermedad, realizar una aproximación pronóstica y planificar un tratamiento adecuado, monitorizar la respuesta a las terapias instauradas y hacer un seguimiento para el diagnóstico de recidiva y reestadificación del linfoma. Sin embargo, aún existen controversias sobre el tema en la literatura médica que repercuten en la práctica diaria. Esta profunda revisión bibliográfica resume la información actual sobre el uso potencial de 18F-FDG-PET/TC en pacientes con linfoma, destacando sus principales aplicaciones y los dilemas que se presentan al evaluar este tipo de estudios, intentando estandarizar criterios para su valoración, particularmente en la reestadificación y monitorización de la terapia.

Palabras clave:
Linfoma
Tomografía de emisión de positrones
PET/TC
SUV
PET/TC con contraste
Pronóstico

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