Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 18F-FDG PET/CT for the detection of large vessel vasculitis in patients with pol...
Journal Information
Vol. 34. Issue 5.
Pages 275-281 (September - October 2015)
Share
Share
Download PDF
More article options
ePub
Visits
322
Vol. 34. Issue 5.
Pages 275-281 (September - October 2015)
Original Article
18F-FDG PET/CT for the detection of large vessel vasculitis in patients with polymyalgia rheumatica
18F-FDG PET/TAC en pacientes con polimialgia reumática y sospecha de vasculitis de grandes vasos asociada
Visits
...
C. Lavado-Péreza, I. Martínez-Rodrígueza,
Corresponding author
mimartinez@humv.es

Corresponding author.
, N. Martínez-Amadora, I. Banzoa, R. Quircea, J. Jiménez-Bonillaa, M. De Arcocha-Torresa, Z. Bravo-Ferrera, M. Jiménez-Alonsoa, J.L. López-Defillóa, R. Blancob, M.A. González-Gayb, J.M. Carrila
a Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain
b Department of Rheumatology, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Tables (5)
Table 1. Patient characteristics.
Table 2. Intensity of 18F-FDG uptake and vascular regions in the 26 patients with large vessel vasculitis.
Table 3. 18F-FDG uptake in each of the 26 patients with large vessel vasculitis according to the different vascular regions evaluated.
Table 4. Intensity of 18F-FDG uptake and vascular regions in the 14 patients with a final diagnosis of no large vessel vasculitis.
Table 5. 18F-FDG uptake in each of the 14 patients with a final diagnosis of no large vessel vasculitis according to the different vascular regions evaluated.
Show moreShow less
Abstract
Purpose

Polymyalgia rheumatica (PMR) may present together with large vessel vasculitis (LVV), and frequently requires a more intensive therapy. The aim of the study was to evaluate the impact of 18F-FDG PET/CT in the diagnosis and management of LVV associated to PMR.

Material and methods

This prospective study included 40 consecutive patients (27 women/13 men, 68.10±10.27 years) with PMR and suspicion of associated LVV submitted for 18F-FDG PET/CT. A PET/CT scan was obtained 180min after 18F-FDG intravenous injection. A visual analysis was performed on the images. Five vascular regions were evaluated: supra-aortic trunks (SAT), thoracic aorta (TA), abdominal aorta (AA), iliac arteries (IA), and femoral/tibioperoneal arteries (FTA). The intensity of uptake was graded from 0 to 3. A final diagnosis of LVV was established in 26/40 patients (65%).

Results

In the 26 patients with a diagnosis of LVV, the highest intensity of 18F-FDG uptake was observed in the TA, SAT, and FTA. All of these patients showed uptake at the TA, with grade 2 and 3 in most cases. In 4 of the 14 patients without LVV, no uptake was observed in any vascular region, and in the other 10 patients only a grade 1 uptake was observed in 1 or to 2 territories. Out of the 20 treated LVV patients, 18F-FDG PET/CT led to a therapeutic change in 17 (85%).

Conclusion

18F-FDG PET/CT was useful in identifying patients with LVV associated to PMR. The detection of vascular inflammation had an important impact, and led to a change of treatment in a high percentage of patients with LVV.

Keywords:
Polymyalgia rheumatica
Large vessel vasculitis
Aortitis
Giant cell arteritis
18F-FDG PET/CT
Positron emission tomography
Resumen
Objetivo

La polimialgia reumática (PMR) puede presentarse asociada a vasculitis de grandes vasos (VGV), necesitando frecuentemente una intensificación del tratamiento. Nuestro objetivo fue evaluar el impacto de la 18F-FDG PET/TAC en el diagnóstico y tratamiento de VGV asociada a PMR.

Material y métodos

Este estudio prospectivo incluyó 40 pacientes consecutivos (27 mujeres/13 hombres, 68,10±10,27 años) con PMR y sospecha de VGV asociada evaluados con 18F-FDG PET/TAC. Los estudios PET/TAC fueron obtenidos 180 minutos después de la inyección intravenosa de 18F-FDG. Se realizó un análisis visual de la intensidad de captación (0–3) en troncos supraaórticos (TSA), aorta torácica (AT), aorta abdominal (AA), arterias ilíacas (AI) y arterias femoro/tibioperoneales (AFT). Se estableció un diagnóstico final de VGV en 26/40 pacientes (65%).

Resultados

En los 26 pacientes con diagnóstico de VGV la mayor intensidad de captación de 18F-FDG se objetivó en AT, TSA y AFT. En todos ellos se observó captación en la AT, principalmente grado 2 y 3. En 4 de los 14 sin VGV no se visualizó captación en ninguna región vascular y en los otros 10 solo se observó captación grado 1 en uno o 2 territorios. De los 20 pacientes con VGV previamente tratados, la 18F-FDG PET/TC motivó un cambio terapéutico en 17 (85%).

Conclusiones

La 18F-FDG PET/TAC fue una herramienta útil para identificar pacientes con VGV asociada a PMR. La detección de inflamación vascular tuvo un importante impacto, motivando un cambio de tratamiento en un alto porcentaje de los pacientes con VGV.

Palabras clave:
Polimialgia reumática
Vasculitis de grandes vasos
Aortitis
Arteritis de células gigantes
18F-FDG PET/TAC
Tomografía por emisión de positrones

Article

These are the options to access the full texts of the publication Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos