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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 18F-FDG PET/contrast enhanced CT in the standard follow-up of patients with lymp...
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Vol. 37. Issue 3.
Pages 151-155 (May - June 2018)
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Vol. 37. Issue 3.
Pages 151-155 (May - June 2018)
Original article
18F-FDG PET/contrast enhanced CT in the standard follow-up of patients with lymphoma
18F-FDG PET/TC con contraste intravenoso en el seguimiento estandarizado de pacientes con linfoma
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A.M. García Vicentea,
Corresponding author
angarvice@yahoo.es

Corresponding author.
, M.P. Talavera Rubioa, E. Dominguez Ferrerasb, C. Calle Primoc, M. Amo-Salasd, M.J. Tello Galána, G.A. Jimèc)nez Londoñoa, F. Jimèc)nez Aragónb, B. Hernández Ruizc, Á. Soriano Castrejóna
a Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain
b Radiology Department, University General Hospital, Ciudad Real, Spain
c Hematology Department, University General Hospital, Ciudad Real, Spain
d Mathematics Department, Castilla-La Mancha University, Ciudad Real, Spain
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Table 1. Diagnostic parameters of the evaluated imaging techniques (patient-basis).
Abstract
Aim

To assess the diagnostic accuracy of 18F-FDG PET/contrast enhanced computed tomography (ceCT) in the detection of asymptomatic recurrences in patients with lymphoma.

Material and methods

Patients with lymphoma and clinical complete remission underwent 18F-FDG PET/ceCT for standard follow-up.18F-FDG PET and ceCT were evaluated blindly by two independent observers, and classified as positive or negative for recurrence. Additionally a combined evaluation of both techniques was performed.

The final diagnosis was established by histopathological analysis or a clinical follow-up longer than 6 months.

Statistical diagnostic parameters and concordance levels between both diagnostic techniques were calculated.

Results

A total of 114 explorations on 90 patients were analyzed. Only 4 patients were diagnosed as asymptomatic recurrence during the follow-up.

18F-FDG PET/ceCT, 18F-FDG PET and ceCT showed an association with the final diagnosis (p=.002 and χ2=11.96; p<.001 and χ2=15.60; p=.001 and χ2=11.96, respectively). The concordance between 18F-FDG PET and ceCT was moderate/high and significant (Kappa=0.672; p<.001).

A sensitivity and specificity of 50% and 88% was obtained for the 18F-FDG PET/ceCT civ, 50% and 93% for the 18F-FDG PET, and 50% and 91% for the ceCT.

Conclusion

The combined use of 18F-FDG PET/ceCT did not offer any advantage compared to any isolated diagnostic technique in the detection of asymptomatic lymphoma recurrence.

Keywords:
Lymphoma
18F-FDG PET/ceCT
Standard follow-up
Asymptomatic recurrence
Resumen
Objetivo

Valorar la capacidad diagnóstica de la 18F-FDG PET/TC con contraste intravenoso (PET/TCciv) en la detección de recidivas asintomáticas de pacientes con linfoma.

Material y mèc)todos

Se realizó una PET/TCciv en pacientes con linfoma para seguimiento estandarizado y en remisión completa clínica. Tanto la 18F-FDG PET como la TCciv fueron evaluadas de forma independiente por 2 observadores y clasificadas como positiva o negativa para recurrencia. Adicionalmente se realizó una valoración combinada de ambas exploraciones.

El diagnóstico final se estableció por análisis histopatológico o seguimiento clínico superior a 6 meses.

Se calcularon los parámetros diagnósticos estadísticos y los niveles de concordancia entre ambas tèc)cnicas diagnósticas.

Resultados

Se analizaron un total de 114 exploraciones pertenecientes a 90 pacientes. Solo 4 pacientes fueron diagnosticados de recurrencia asintomática durante el seguimiento.

La 18F-FDG PET/TCciv, la 18F-FDG PET y la TCciv mostraron asociación con el diagnóstico final (p=0,002 y χ2=11,96; p<0,001 y χ2=15,60; p=0,001 y χ2=11,96 respectivamente). La concordancia entre la 18F-FDG PET y la TC civ fue moderada/alta y significativa (Kappa=0,672; p<0,001).

Se obtuvo una sensibilidad y especificidad del 50% y 88% para la 18F-FDG PET/TCciv, del 50% y 93% para la 18F-FDG PET y del 50% y 91% para la TCciv.

Conclusión

El uso combinado de la 18F-FDG PET/TCciv no ofreció ventaja con respecto a ambas tèc)cnicas por separado en la detección de recidiva asintomática por linfoma.

Palabras clave:
Linfoma
18F-FDG PET/TC con contraste intravenoso
Seguimiento estándar
Recidiva asintomática

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