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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 111In-octreotide SPECT–CT in head and neck paragangliomas
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Vol. 34. Issue 5.
Pages 321-324 (September - October 2015)
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Vol. 34. Issue 5.
Pages 321-324 (September - October 2015)
Clinical note
111In-octreotide SPECT–CT in head and neck paragangliomas
SPECT-TC con 111In-octreotide en paragangliomas de cabeza y cuello
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C. Castillo-Berrio
Corresponding author
caritocas541@hotmail.com

Corresponding author.
, M. Castrillón, F. Zelaya, D. Ruíz, F. Loira, J.M. Nogueiras, A. López, R. Guitián, J. Outomuro, A. Serena, L.M. Campos
Servicio de Medicina Nuclear, Hospital Meixoeiro, Vigo, Pontevedra, Spain
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Abstract

Head and neck paragangliomas are rare neuroendocrine tumours expressing somatostatin receptors on their cell surface, particularly subtype 2. Due to this distinctive feature, images can be obtained in Nuclear Medicine using synthetic analogues of somatostatin, mainly octreotide, which allow selective display by planar scintigraphy, SPECT–CT or PET–CT imaging after radiolabeling with 111In or 68Ga.

Three cases have been selected and presented from a series of patients that illustrate the utility of SPECT–CT studies with 111In-octreotide in the diagnosis and monitoring of this type of tumour. These are characterization at initial diagnosis, staging, and detection of local recurrence or metastasis, with added value with respect to anatomical images (nuclear magnetic resonance, computed axial tomography, angiography), for example in the differentiation between functional tissue or scar in patients who had previously undergone surgery.

Keywords:
Paraganglioma
Scintigraphy
SPECT–CT
111In-octreotide
Somatostatin
Resumen

Los paragangliomas de cabeza y cuello son tumores neuroendocrinos poco frecuentes, que expresan receptores para la somatostatina (RSS) en su superficie celular, particularmente el subtipo 2. Por esta particularidad, en la Medicina Nuclear es posible obtener imágenes de los mismos mediante la utilización de análogos sintéticos de la somatostatina, principalmente el octreotide, el cual tras su radiomarcaje con 111In o 68Ga, permiten su visualización selectiva, bien por imágenes gammagráficas planares, SPECT-TC o PET-TC.

De una serie de pacientes se seleccionan y presentan 3 casos que ilustran la utilidad de los estudios SPECT-TC con 111In-octreotide en el diagnóstico y seguimiento de este tipo de tumour: caracterización y diagnóstico inicial, estadificación y detección de recurrencia local o metástasis, y su valour añadido respecto a las imágenes anatómicas (resonancia magnética, tomografía computarizada, angiografía), por ejemplo en la diferenciación entre tejido funcional o cicatricial en los pacientes sometidos previamente a cirugía.

Palabras clave:
Paraganglioma
Gammagrafía
SPECT-TC
111In-octreotide
Somatostatina

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