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Vol. 27. Issue S1.
Systemic Sclerosis
Pages 55-61 (April 2020)
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Vol. 27. Issue S1.
Systemic Sclerosis
Pages 55-61 (April 2020)
Review article
DOI: 10.1016/j.rcreue.2020.03.003
Renal involvement in scleroderma
Alteraciones renales en la esclerodermia
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Yimy F. Medina
Corresponding author
, Daniel Medina Torres
Universidad Nacional de Colombia, Colombia
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Table 1. Key characteristics of scleroderma renal complications.
Abstract

Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by vasculopathy, inflammation, collagen deposits and fibrosis in the skin and internal organs. Renal complications are common in SSc. The spectrum of renal complications in systemic sclerosis includes scleroderma renal crisis (SRC), abnormal renal function, proteinuria, renal chronic vascular disease, kidney injury from nephrotoxic drugs, oxalate calcium nephropathy, glomerulonephritis and vasculitis associated to anti-neutrophil cytoplasmic antibody. Renal involvement remains an important cause of morbidity and mortality in scleroderma. The objective of this review is to describe the renal complications of scleroderma.

Keywords:
Systemic sclerosis
Scleroderma renal crisis
Kidney
Renal function
Resumen

La esclerosis sistémica en una enfermedad autoinmune generalizada que se caracteriza por vasculopatía, inflamación, depósito de colágeno y fibrosis en la piel y órganos internos. Las complicaciones renales son comunes y con un amplio espectro que incluye crisis renal esclerodermica, función renal anormal, proteinuria, enfermedad vascular renal crónica, injuria renal por fármacos nefrotóxicos, nefropatía por oxalato de calcio, glomerulonefritis y vasculitis asociadas a anticuerpos contra el citoplasma de los neutrófilos. La alteración renal permanece siendo una causa importante de movilidad y mortalidad en la esclerodermia. El objetivo de esta revisión narrativa es describir las complicaciones renales de la esclerodermia.

Palabras clave:
Esclerosis sistémica
Crisis renal esclerodermica
Riñón
Función renal

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