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Revista Colombiana de Reumatología (English Edition)
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Vol. 27. Issue S1.
Systemic Sclerosis
Pages 44-54 (April 2020)
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Vol. 27. Issue S1.
Systemic Sclerosis
Pages 44-54 (April 2020)
Review Article - Meta-analysis
DOI: 10.1016/j.rcreue.2019.12.003
Systemic sclerosis and gastrointestinal involvement
Jose Luis Tandaipana, Ivan Castellvíb,
Corresponding author

Corresponding author at: Department of Rheumatology Hospital de la Santa Creu i Sant Pau Carrer de Mas Casanovas 90 08041, Barcelona, Spain.
a Department of Rheumatology, Hospital Universitari Mútua de Terrassa, Terrassa. Spain
b Autoimmune Diseases Unit, Department of Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona. Spain
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Table 1. Complications of gastrointestinal involvement in SSc.

Systemic sclerosis (SSc) is a systemic autoimmune disease in which gastrointestinal manifestations are a frequent complication. Gastrointestinal involvement is present in up to 90 % of patients. The most affected areas are the esophagus and the anorectal tract. Reflux, heartburn and dysmotility are the leading causes of gastrointestinal discomfort. Disordered anorectal function can occur early in the course of SSc and is an important factor in the development of fecal incontinence. Current recommendations to treat gastrointestinal disorders in SSc include the use of proton pump inhibitors, prokinetics and rotating antibiotics. This review discusses the proposed pathophysiological mechanisms, the clinical presentation, the different diagnostic techniques and the current management of the involvement of each section of the gastrointestinal tract in SSc.

Systemic sclerosis
Chronic intestinal pseudo-obstruction
Fecal incontinence
Gastroesophageal reflux disease
Small intestinal bacterial overgrowth.


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