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Vol. 27. Issue 1.
Pages 46-49 (January - March 2020)
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Vol. 27. Issue 1.
Pages 46-49 (January - March 2020)
Case Report
DOI: 10.1016/j.rcreue.2020.02.002
Renal amyloidosis in ankylosing spondylitis: A case report
Amiloidosis renal en espondilitis anquilosante: un reporte de caso
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Juan David Romero-Marína, Yeison Cantorb, Esteban Prieto-Bravoc, Reinaldo Sierra-Rosalesd, Adriana Flórez-Vargase, Miguel Antonio Mesa-Navasf, Carlos Jaime Velásquez-Francof,
Corresponding author
carjaivel@gmail.com

Corresponding author.
a Internal Medicine Department, IPS Universitaria, Medellin, Colombia
b School of Health Sciences, Universidad Pontificia Bolivariana, Medellin, Colombia
c Orthopedics Department, Universidad Pontificia Bolivariana, Medellin, Colombia
d Nephrology Department, SURA EPS, Medellin, Colombia
e Pathology Department, Hospital Universitario Fundación Santa Fe de Bogota, Bogota, Colombia
f Rheumatology Department, Clinica Universitaria Bolivariana, School of Health Sciences Universidad Pontificia Bolivariana, Medellin, Colombia
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Table 1. Lab tests.
Abstract

Renal manifestations of spondyloarthritis are rare. The case is presented of a patient with ankylosing spondylitis of nine years of evolution. He had intense inflammation, as well as articular sequelae, with a significant deterioration in his quality of life. At the initial evaluation, the patient had a serum creatinine of 1.44mg/dL and a 24-h urine protein in the sub-nephrotic range (1.44g). Renal biopsy showed the presence of Congophilic material, confirming the diagnosis of AA amyloidosis. Treatment with a TNF blocking agent was initiated with clinical improvement, especially regarding articular disease.

Keywords:
Amyloidosis
Kidney
Ankylosing Spondylitis
Resumen

Las manifestaciones renales de la espondiloartritis son poco comunes. Se presenta el caso de un paciente con espondilitis anquilosante de 9 años de evolución, con intensa inflamación y secuelas articulares y con un deterioro significativo en su calidad de vida. En la evaluación inicial, el paciente tenía una creatinina sérica de 1,44mg/dL y una proteína en orina de 24 horas en un rango subnefrótico (1,44 g). La biopsia renal mostró la presencia de material congofílico que confirmaba el diagnóstico de amiloidosis AA. Se inició tratamiento con un anti-TNF, con mejoría clínica, especialmente con respecto al componente articular.

Palabras clave:
Amiloidosis
Riñón
Espondilitis anquilosante

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