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Vol. 59. Issue 5.
Pages 368-379 (September - October 2017)
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Vol. 59. Issue 5.
Pages 368-379 (September - October 2017)
Update in Radiology
DOI: 10.1016/j.rxeng.2017.08.001
Breast cancer in the 21st century: From early detection to new therapies
El cáncer de mama en el siglo XXI: de la detección precoz a los nuevos tratamientos
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J.A. Merino Bonillaa,
Corresponding author
jamerinob@gmail.com

Corresponding author.
, M. Torres Tabanerab, L.H. Ros Mendozac
a Servicio de Radiodiagnóstico, Hospital Santiago Apóstol, Miranda de Ebro (Burgos), Spain
b Servicio de Radiodiagnóstico, Hospital Universitario HM Puerta del Sur, Móstoles (Madrid), Spain
c Servicio de Radiodiagnóstico, Hospital Universitario Miguel Servet, Zaragoza, Spain
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Table 1. Molecular classification of breast cancer according to immunochemistry markers.
Table 2. Main characteristics of population screening and opportunistic screening of breast cancer.
Table 3. International recommendations on population screenings of breast cancer.
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Abstract

The analysis of the causes that have given rise to a change in tendency in the incidence and mortality rates of breast cancer in the last few decades generates important revelations regarding the role of breast screening, the regular application of adjuvant therapies and the change of risk factors. The benefits of early detection have been accompanied by certain adverse effects, even in terms of an excessive number of prophylactic mastectomies. Recently, several updates have been published on the recommendations in breast cancer screening at an international level. On the other hand, the advances in genomics have made it possible to establish a new molecular classification of breast cancer. Our aim is to present an updated overview of the epidemiological situation of breast cancer, as well as some relevant issues from the point of view of diagnosis, such as molecular classification and different strategies for both population-based and opportunistic screening.

Keywords:
Breast cancer
Incidence
Mortality
Mammography screening
Adjuvant therapy
Resumen

El análisis de las causas que han provocado un cambio de tendencia en la incidencia y la mortalidad del cáncer de mama en las últimas décadas genera revelaciones importantes sobre el papel del cribado mamográfico, el empleo regular de terapias adyuvantes y la alteración de los factores de riesgo. Los beneficios de la detección precoz se han acompañado de ciertos efectos adversos, incluso en forma de un excesivo número de mastectomías profilácticas. Recientemente se han publicado diversas actualizaciones internacionales sobre las recomendaciones en cribado del cáncer de mama. Por otra parte, los avances en genómica han permitido establecer una nueva clasificación molecular del cáncer de mama. Nuestro objetivo es presentar una visión actualizada de la situación epidemiológica del cáncer de mama y de algunas cuestiones relevantes desde el punto de vista del diagnóstico, como son la clasificación molecular y las diferentes estrategias de cribado, poblacional y oportunista.

Palabras clave:
Cáncer de mama
Incidencia
Mortalidad
Cribado con mamografía
Tratamiento adyuvante

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