Original article
Histological changes in the rat brain and spinal cord following prolonged intracerebroventricular infusion of cerebrospinal fluid from amyotrophic lateral sclerosis patients are similar to those caused by the disease
La infusión intracerebroventricular prolongada de líquido cefalorraquídeo procedente de pacientes con esclerosis lateral amiotrófica provoca cambios histológicos en el cerebro y la médula espinal de la rata similares a los hallados en la enfermedad
U. Gómez-Pinedoa,
, L. Galánb, M. Yañezc, J. Matias-Guiub, C. Valenciab, A. Guerrero-Solab, F. Lopez-Sosaa, J.R. Brinc, M.S. Benito-Martina, G. Leon-Espinosaa, A. Vela-Soutob, C. Lendinezc, T. Guillamón-Vivancosa, J.A. Matias-Guiua,b, J.A. Arranz-Tagarrod, J.A. Barciac, A.G. Garciad
Corresponding author
a Laboratorio de Neurobiología, Instituto de Neurociencias, IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain
b Servicio de Neurología, IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain
c Servicio de Neurocirugía, IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain
d Instituto Teófilo Hernando, Departamento de Farmacología Terapéutica, Universidad Autónoma de Madrid, Madrid, Spain
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