Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Relationship between glycaemic levels and arterial stiffness in non-diabetic adu...
Journal Information
Vol. 150. Issue 2.
Pages 56-60 (January 2018)
Share
Share
Download PDF
More article options
ePub
Visits
0
Vol. 150. Issue 2.
Pages 56-60 (January 2018)
Brief report
DOI: 10.1016/j.medcle.2017.11.034
Relationship between glycaemic levels and arterial stiffness in non-diabetic adults
Relación entre los niveles de glucemia y la rigidez arterial en adultos no diabéticos
Visits
...
Iván Cavero-Redondoa, Vicente Martínez-Vizcaínoa,b,
Corresponding author
Vicente.Martinez@uclm.es

Corresponding author.
, Celia Álvarez-Buenoa, José Ignacio Recio-Rodríguezc,d, Manuel Ángel Gómez-Marcosc,e, Luis García-Ortizc,f
a Centro de Investigación Sanitaria y Social, Universidad de Castilla-La Mancha, Cuenca, Spain
b Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile
c Instituto de Investigación Biomédica de Salamanca (IBSAL), Unidad de Investigación de Atención Primaria, Centro de Salud La Alamedilla, Servicio de Salud de Castilla León, Salamanca, Spain
d Departamento de Enfermería y Fisioterapia, Universidad de Salamanca, Salamanca, Spain
e Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain
f Departamento de Ciencias Biomédicas y Diagnósticas, Universidad de Salamanca, Salamanca, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (3)
Table 1. Descriptive characteristics of study population.
Table 2. ANCOVA model for differences in arterial stiffness-related parameters between HbA1c and FPG tertile levels.
Table 3. Differences in arterial stiffness-related parameters between HbA1c and FPG categories after propensity score matching.
Show moreShow less
Abstract
Objective

To examine, in a non-diabetic population, whether the association between arterial stiffness and glycaemic levels depends on the test used as a glycaemic indicator, fasting plasma glucose (FPG) or glycated haemoglobin A1c (HbA1c).

Patient population and methods

A cross-sectional analysis of a 220 non-diabetic subsample from the EVIDENT II study in which FPG, HbA1c and arterial stiffness-related parameters (pulse wave velocity, radial and central augmentation index, and central pulse pressure) were determined. Mean differences in arterial stiffness-related parameters by HbA1c and FPG tertiles were tested using analysis of covariance.

Results

All means of arterial stiffness-related parameters increased by HbA1c tertiles, although mean differences were only statistically significant in pulse wave velocity (p0.001), even after controlling for potential confounders (HbA1c <5.30%=6.88m/s; HbA1c 5.30–5.59%=7.06m/s; and HbA1c ≥5.60%=8.16m/s, p=0.004). Conversely, mean differences in pulse wave velocity by FPG tertiles did not reach statistically significant differences after controlling for potential confounders (FPG 4.44mmol/l=7.18m/s; FPG 4.44–4.87mmol/l=7.26m/s; and FPG ≥4.88mmol/l=7.93m/s, p=0.066).

Conclusions

Glucose levels in a non-diabetic population were associated with arterial stiffness but better when levels were determined using HbA1c.

Keywords:
Glycated haemoglobin
Fasting plasma glucose
Arterial stiffness
HbA1c
Pulse wave velocity
Resumen
Objetivo

Examinar, en una población no diabética, si la asociación entre la rigidez arterial y los niveles glucémicos depende de la prueba utilizada como indicador glucémico, glucosa en ayunas o hemoglobina glicosilada A1c (HbA1c).

Población de pacientes y métodos

Análisis transversal de una submuestra de 220 no diabéticos del estudio EVIDENT II en el que se determinaron los parámetros relacionados con glucosa en ayunas, HbA1c y rigidez arterial (velocidad de onda de pulso, índice de aumento radial y central y presión de pulso central). Las diferencias de medias entre los parámetros relacionados con la rigidez arterial en cada tercil de HbA1c y glucosa en ayunas se determinaron mediante un análisis de covarianza.

Resultados

La media de todos los parámetros de rigidez arterial aumentaba por cada tercil de HbA1c, aunque las diferencias de medias solamente fueron estadísticamente significativas para la velocidad de la onda de pulso (p < 0,001), incluso tras ajustar por los potenciales factores de confusión (HbA1c <5,3% = 6,88m/s; HbA1c 5,3%-5,59% = 7,06m/s; y HbA1c 5,6% = 8,16m/s, p = 0,004). Por el contrario, las diferencias de medias en la velocidad de onda de pulso por terciles de glucosa en ayunas no mostraron diferencias estadísticamente significativas después de ajustar por estos factores de confusión (glucosa 4,44mmol/l = 7,18m/s; glucosa 4,44mmol/l-4,87mmol/l= 7,26m/s; y glucosa ≥4,88mmol/l= 7.93m/s, p = 0,066).

Conclusiones

Los niveles de glucosa en la población no diabética se asociaron a rigidez arterial, aunque de forma más estrecha cuando esos niveles se determinaron usando HbA1c.

Palabras clave:
Hemoglobina glicosilada
Glucosa plasmática en ayunas
Rigidez arterial
HbA1c
Velocidad de la onda de pulso

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Clínica (English Edition)

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos