TY - JOUR T1 - Relationship between glycaemic levels and arterial stiffness in non-diabetic adults JO - Medicina Clínica (English Edition) T2 - AU - Cavero-Redondo,Iván AU - Martínez-Vizcaíno,Vicente AU - Álvarez-Bueno,Celia AU - Recio-Rodríguez,José Ignacio AU - Gómez-Marcos,Manuel Ángel AU - García-Ortiz,Luis SN - 23870206 M3 - 10.1016/j.medcle.2017.11.034 DO - 10.1016/j.medcle.2017.11.034 UR - https://www.elsevier.es/en-revista-medicina-clinica-english-edition--462-articulo-relationship-between-glycaemic-levels-arterial-S2387020617307751 AB - ObjectiveTo examine, in a non-diabetic population, whether the association between arterial stiffness and glycaemic levels depends on the test used as a glycaemic indicator, fasting plasma glucose (FPG) or glycated haemoglobin A1c (HbA1c). Patient population and methodsA cross-sectional analysis of a 220 non-diabetic subsample from the EVIDENT II study in which FPG, HbA1c and arterial stiffness-related parameters (pulse wave velocity, radial and central augmentation index, and central pulse pressure) were determined. Mean differences in arterial stiffness-related parameters by HbA1c and FPG tertiles were tested using analysis of covariance. ResultsAll means of arterial stiffness-related parameters increased by HbA1c tertiles, although mean differences were only statistically significant in pulse wave velocity (p≤0.001), even after controlling for potential confounders (HbA1c <5.30%=6.88m/s; HbA1c 5.30–5.59%=7.06m/s; and HbA1c ≥5.60%=8.16m/s, p=0.004). Conversely, mean differences in pulse wave velocity by FPG tertiles did not reach statistically significant differences after controlling for potential confounders (FPG 4.44mmol/l=7.18m/s; FPG 4.44–4.87mmol/l=7.26m/s; and FPG ≥4.88mmol/l=7.93m/s, p=0.066). ConclusionsGlucose levels in a non-diabetic population were associated with arterial stiffness but better when levels were determined using HbA1c. ER -