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Inicio Medicina Clínica (English Edition) Incidence of haematological neoplasms in Castilla y León, Spain
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Vol. 144. Issue 11.
Pages 491-500 (June 2015)
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Vol. 144. Issue 11.
Pages 491-500 (June 2015)
Original article
Incidence of haematological neoplasms in Castilla y León, Spain
Estudio de incidencia de las neoplasias hematopoyéticas en Castilla y León
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José Antonio Rodríguez-Garcíaa,
Corresponding author
, Lourdes Vázquezb, Fernando Ramosa, Beatriz Cuevasc, Alejandro Martínb,d, Alicia Smuclere, Dulce Nombre Guerolaf, Alberto Cantalapiedrag, José María Alonsoh, Silvia Fernándeza, Eva Díezb, María Jesús Rodríguezi, María José Calmuntiaj, Carlos Aguilark, Magdalena Sierrad, José Antonio Graciak, María José Cebeiraf, Rosa Cantalejol, on behalf of the Registro de Enfermedades Hematológicas de Castilla y León (REHCL) Working Group, Sociedad Castellano-Leonesa de Hematología y Hemoterapia
a Servicio de Hematología, Complejo Asistencial Universitario de León, León, Spain
b Servicio de Hematología, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
c Servicio de Hematología, Complejo Asistencial Universitario de Burgos, Burgos, Spain
d Servicio de Hematología, Complejo Asistencial de Zamora, Zamora, Spain
e Servicio de Hematología, Hospital El Bierzo, Ponferrada, León, Spain
f Servicio de Hematología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
g Servicio de Hematología, Hospital Universitario Río Hortega, Valladolid, Spain
h Servicio de Hematología, Complejo Asistencial de Palencia, Palencia, Spain
i Servicio de Hematología, Complejo Asistencial de Ávila, Ávila, Spain
j Servicio de Hematología, Complejo Asistencial de Segovia, Segovia, Spain
k Servicio de Hematología, Complejo Asistencial de Soria, Soria, Spain
l Servicio de Hematología, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain
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Tables (6)
Table 1A. Distribution of neoplasms based on several variables (time, age, geography and gender). Number of recorded cases of each type of neoplasm throughout the period of the study.
Table 1B. Distribution of neoplasms based on several variables (time, age, geography and gender). Gross incidence per age for each type of neoplasm.
Table 1C. Distribution of neoplasms based on several variables (time, age, geography and gender). Incidence adjusted to the European standard population for each type of neoplasm in the provinces of Castile and León.
Table 1D. Distribution of neoplasms based on several variables (time, age, geography and gender). Percentage of each group of neoplasms and their distribution by gender and age.
Table 2. Number of cases, relative frequency, distribution by age and gender and incidence adjusted to the European standard population - myeloid neoplasms.
Table 3. Number of cases, relative frequency, distribution by age and gender and incidence adjusted to the European standard population - lymphoid neoplasms.
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Abstract
Background and objective

We aimed to assess the incidence of haematological neoplasms (HNs) in Castilla y León (2.5 million inhabitants) and its distribution by age, gender and histological type.

Patients and method

The epidemiological profile based on the described variables of the 10,943 HNs diagnosed during a 10-years period was analysed, compared with other studies.

Results

The overall age-adjusted incidence was 29.4 cases/105 inhabitants-year, with some geographical differences. The mean age was 67.3 years, with a turning point between the 6th and 7th decades of life from which there was a very significant increase of incidence. Two relevant facts where simultaneous with advancing age: decreased lymphoid neoplasms incidence and increased low degree neoplasms incidence. Lymphoid low degree neoplasms accounted for half of the registered processes, showed the greatest preference for male and reached the mode before the rest of neoplasms. Myeloid neoplasms incidence (9.5) was higher than that reported in other European registries, specially compared to southern European countries, opposite to lymphoid neoplasms incidence (20.0).

Conclusions

A higher myeloid neoplasms incidence and lower lymphoid one than expected was observed. The turning point of incidence is between the 6th and 7th decades of life, with a preference for male that decreases with age. There is an increased incidence of HNs in the area where a higher density of potentially polluting facilities is concentrated.

Keywords:
Epidemiology
Incidence
Haematological neoplasms
Leukaemia
Lymphoma
Myeloma
Myeloid neoplasms
Lymphoid neoplasms
Resumen
Fundamento y objetivo

Conocer la incidencia de las neoplasias hematopoyéticas (NH) en Castilla y León, una región de 2,5 millones de habitantes, y su distribución en función de la edad, el sexo y el subtipo histológico.

Pacientes y método

Se ha analizado el perfil epidemiológico en función de las variables descritas de las 10.943 NH diagnosticadas durante un período de 10 años, comparándolo con el de otros estudios.

Resultados

La incidencia ajustada por edad alcanzó 29,4 casos/105 habitantes-año, con ciertas variaciones geográficas. La edad media fue de 67,3 años, con un punto de inflexión entre la sexta y séptima décadas de la vida, a partir del cual se produjo un aumento muy importante de la incidencia. A medida que avanzaba la edad, ocurrieron de forma paralela otros 2 hechos relevantes: una disminución de la incidencia de los procesos linfoides y el aumento de la de las neoplasias de bajo grado de agresividad. Los procesos linfoides de bajo grado representaron la mitad de los casos del registro, mostraron una mayor preferencia por el sexo masculino y alcanzaron la moda antes que el resto de las NH. La incidencia de neoplasias mieloides (9,5) fue superior a la descrita en otros registros europeos, especialmente en los países del sur de Europa, contrariamente a lo observado con las neoplasias linfoides (20,0).

Conclusiones

Se observó una mayor incidencia de neoplasias mieloides y menor de linfoides de lo esperado. El punto de inflexión de incidencia se situó entre la sexta y séptima décadas de la vida, con predominio del sexo masculino, que se reduce con el aumento de la edad. La mayor incidencia de NH se observó en la zona donde se concentra una mayor densidad de industrias potencialmente contaminantes.

Palabras clave:
Epidemiología
Incidencia
Neoplasias hematopoyéticas
Leucemia
Linfoma
Mieloma
Neoplasias mieloides
Neoplasias linfoides

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