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Inicio Medicina Clínica (English Edition) Dyslipidaemia and atherogenic risk in patients with systemic lupus erythematosus
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Vol. 147. Issue 2.
Pages 63-66 (July 2016)
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Vol. 147. Issue 2.
Pages 63-66 (July 2016)
Brief report
DOI: 10.1016/j.medcle.2016.03.029
Dyslipidaemia and atherogenic risk in patients with systemic lupus erythematosus
Dislipidemia y riesgo aterogénico en pacientes con lupus eritematoso sistémico
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José Antonio de Jesús Batún Garridoa,
Corresponding author
antonio_bg1986@hotmail.com

Corresponding author.
, Hugo Alberto Radillo Albaa, Éufrates Hernández Núñezb, Francisco Olánb
a Residente de tercer año de Medicina Interna, Hospital Regional de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez, Villahermosa , Tabasco, Mexico
b Médico Internista y Reumatólogo, Hospital Regional de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez, Villahermosa, Tabasco, Mexico
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Tables (3)
Table 1. Distribution of dyslipidaemic and non dyslipidaemic patients according to their general characteristics.
Table 2. Lipid profile analysis of variance and general characteristics of patients with systemic lupus erythematosus.
Table 3. Multivariate analysis of the variables studied and their association with the development of dyslipidaemia.
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Abstract
Introduction

Dyslipidaemia is a common comorbidity in patients with systemic lupus erythematosus.

Patients and methods

Fifty-one patients were included. Variables associated with the disease and the drugs used were recorded. Atherogenic risk was calculated. Chi square was used for categorical variables. ANOVA was performed and a logistic regression model to determine the association of the variables with the presence of dyslipidaemia.

Results

A percentage of 68.6 had dyslipidaemia. A significant difference between the presence of dyslipidaemia and activity index measured by SLEDAI was found, the presence of lupus nephritis, use of prednisone ≥20mg/day, evolution of the disease <3 years. Significance between the absence of dyslipidaemia and use of hydroxychloroquine was found. SLEDAI ≥4 and the use of prednisone ≥20mg/day were independently associated with the presence of dyslipidaemia. The average of Castelli rate was 5.02, the Kannel index was 2.97 and triglyceride/HDL-C ratio was 5.24.

Conclusions

Patients with systemic lupus erythematosus have a high prevalence of dyslipidaemia and a high atherogenic rate, which increases cardiovascular risk significantly.

Keywords:
Systemic lupus erythematosus
Dyslipidaemia
Atherogenic index
Resumen
Introducción

La dislipidemia es una comorbilidad frecuente en los pacientes con lupus eritematoso sistémico.

Pacientes y métodos

Se incluyeron 51 pacientes. Se registraron variables asociadas a la enfermedad y los fármacos empleados. Se calculó el riesgo aterogénico. Se empleó la prueba de Chi cuadrado para las variables categóricas. Se realizó ANOVA y un modelo de regresión logística para determinar la asociación de las variables con la presencia de dislipidemia.

Resultados

El 68,6% presentó dislipidemia. Se encontró diferencia significativa entre la presencia de dislipidemia y el índice de actividad medido por SLEDAI, la presencia de nefropatía lúpica, el uso de prednisona20mg/día, la evolución de la enfermedad<3 años y entre la ausencia de dislipidemia y el empleo de hidroxicloroquina. SLEDAI4 y el uso de prednisona20mg/día se asociaron independientemente con la presencia de dislipidemia. La media del índice de Castelli fue de 5,02, la del de Kannel fue de 2,97 y la de triglicéridos/c-HDL fue de 5,24.

Conclusiones

Los pacientes con lupus eritematoso sistémico presentan una gran prevalencia de dislipidemia y un alto índice aterogénico, lo cual aumenta el riesgo cardiovascular.

Palabras clave:
Lupus eritematoso sistémico
Dislipidemia
Índice aterogénico

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