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Inicio Medicina Clínica (English Edition) Increased interferon-1α, interleukin-10 and BLyS concentrations as clinical act...
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Vol. 153. Issue 6.
Pages 225-231 (September 2019)
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Vol. 153. Issue 6.
Pages 225-231 (September 2019)
Original article
DOI: 10.1016/j.medcle.2019.07.003
Increased interferon-1α, interleukin-10 and BLyS concentrations as clinical activity biomarkers in systemic lupus erythematosus
Aumento de las concentraciones de interferón-1α, interleucina-10 y BLyS como biomarcadores de actividad clínica en el lupus eritematoso sistémico
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Meritxell Fernández Matillaa,b,
Corresponding author
nerhetva@gmail.com

Corresponding author.
, Elena Grau Garcíac, Nagore Fernández-Llanio Comellab, Inmaculada Chalmeta Verdejoc, José Ivorra Cortésc, Juan Antonio Castellano Cuestab, José Andrés Román Ivorrac
a Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain
b Sección de Reumatología, Hospital Arnau de Vilanova, Valencia, Spain
c Servicio de Reumatología, Hospital Universitario y Politécnico la Fe, Valencia, Spain
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Tables (4)
Table 1. Analysis of autoantibodies in our patients.
Table 2. Concentration of cytokines in controls and patients.
Table 3. Classification of patients according to cytokine concentrations.
Table 4. Cytokine profiles in patients.
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Abstract
Background and objective

To analyse the association between interferon-1α (INF1α), interleukin-10 (IL-10) and BLyS concentrations and clinical activity in systemic lupus erythematosus (SLE).

Patients and methods

A cross-sectional, observational study of 142 SLE patients and 34 healthy controls was performed, through a complete blood and urine test and review of their medical history. Serum concentration of INF1α, IL-10 and BLyS was determined by colorimetric methods. A biostatistical analysis was performed with R (3.3.2).

Results

69% of our SLE patients showed at least one cytokine increased. INF1α, IL-10 and BLyS are higher in SLE patients than in healthy controls (p<0.001, p=0.005 and p=.043, respectively), being INF1α the most frequent. Patients were categorised according to low or high concentrations of the three cytokines. We found a significant association between increased IL-10/INF1α concentrations and a higher clinical activity measured by SELENA-SLEDAI (p<0.0001) and, to a lesser extent, an association with increased INF1α/IL-10/BLyS concentrations. Elevated levels of IL-10/INF1α and INF1α/IL-10/BLyS related to increased C3-C4 consumption (p<0.001 and p=0.001, respectively) and anti-dsDNA titres (p=0.001 and p=0.002, respectively). Elevated INF1α/BLyS related to higher anti-dsDNA titres (p=0.004) and ENA positivity (p<0.001). Increased levels of INF1α/IL-10/BLyS related to positivity of ANAs (p<0.001) and APL (p=0.004).

Conclusions

INF1α, IL-10 and BLyS are higher in SLE patients than in healthy controls. Increased IL-10 levels, regardless of whether or not there were also increased levels of BLyS and/or INF1α, was the cytokine that best fit with clinical activity in SLE measured with classic methods.

Keywords:
INF1α
IL-10
BLyS
Systemic lupus erythematosus
Clinical activity
Resumen
Fundamento y objetivo

Analizar la asociación entre concentraciones de interferón-1α (INF1α), interleucina 10 (IL-10) y BLyS con la actividad clínica en el lupus eritematoso sistémico (LES).

Pacientes y métodos

Estudio observacional transversal de 142 pacientes con LES y 34 controles sanos mediante analítica de sangre y orina y revisión de la historia clínica. La concentración sérica de citocinas se determinó mediante métodos colorimétricos. El análisis bioestadístico se realizó con R (3.3.2).

Resultados

El 69% de pacientes mostraron al menos una citocina aumentada. Las tres citocinas están más elevadas en pacientes que en controles (p<0,001, p=0,005 y p=0,043), siendo INF1α el más frecuente. Los pacientes fueron categorizados según las concentraciones de las tres citocinas. Encontramos una asociación significativa entre concentraciones elevadas de IL-10/INF1α y una mayor actividad clínica según SELENA-SLEDAI (p<0,0001) y, en menor medida, con concentraciones aumentadas de INF1α/IL-10/BLyS. Concentraciones elevadas de IL-10/INF1α e INF1α/IL-10/BLyS se relacionaron con un mayor consumo de C3-C4 (p<0,001 y p=0,001) y títulos elevados de anti-dsDNA (p=0,001 y p=0,002). Concentraciones elevadas de INF1α/BLyS se relacionaron con títulos más altos de anti-dsDNA (p=0,004) y positividad ENA (p<0,001). Concentraciones altas de INF1α/IL-10/BLyS se relacionaron con la positividad de ANA (p<0,001) y anticuerpos antifosfolípidos (p=0,004).

Conclusiones

INF1α, IL-10 y BLyS están más elevados en pacientes con LES que en controles sanos. El aumento de IL-10, asociado o no a aumento de BLyS y/o INF1α, es la citocina que mejor se ajusta a la actividad clínica del LES medida con métodos clásicos.

Palabras clave:
INF1α
IL-10
BLyS
Lupus eritematoso sistémico
Actividad clínica

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