ISSN: 1665-2681

Annals of Hepatology (AoH) is an international, open access journal published bi-monthly with funds from the Fundación Clínica Médica Sur. It is the official journal of the Mexican Association of Hepatology (AMH), the Latin American Association for the Study of the Liver (ALEH), the Canadian Association for the Study of the Liver (CASL) and the Czech Society of Hepatology (CSH). AoH publishes editorials, opinions, concise reviews, original articles, brief reports, letters to the editor, news from affiliated associations, clinical practice guidelines and summaries of congresses in the field of Hepatology.

Topics covered by AoH include alcoholic liver disease, autoimmune hepatitis, biliary diseases, drug-induced liver injury, genetic liver diseases, NAFLD/NASH and viral hepatitis (HAV, HBV, HCV, HDV, HEV). Our journal seeks to publish articles on basic clinical care and translational research focused on preventing rather than treating the complications of end-stage liver disease.

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Original article

Alterations in one-carbon metabolism in metabolic dysfunction associated steatotic liver disease may be modified by semaglutide

Mikkel Parsberg Wergea,1, Adrian McCannb, Elias Badal Rashua, Shi Min Lama, Liv Eline Hetlanda, Mira Thinga, Puria Nabiloua, Anders Ellekaer Junkera, Jenny Norlinc, Sanne Veidald, Dorte Holstd, Anne Bugged, Birgitte Martine Viuffd, Henning Hvidd, Kristian M. Bendtsene, Gianluca Mazzonie, Lea Moerch Hardere, Mogens Vybergf,g, Reza Serizawaf, Flemming Bendtsena..., Per Magne Uelandb, Elisabeth Douglas Galsgaardc,1, Nicolai J. Wewer Albrechtsenh,i,1, Lise Lotte Gluuda,j,

Corresponding author

lise.lotte.gluud.01@regionh.dk

Corresponding author.

a Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

b Bevital AS, Bergen, Norway

c Global Translation, Novo Nordisk A/S, Novo Nordisk Park, Måløv, Denmark

d Global Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, Måløv, Denmark

e Digital Science & Innovation, Novo Nordisk A/S, Novo Nordisk Park, Måløv, Denmark

f Department of Pathology, Copenhagen University Hospital Hvidovre, Denmark

g Center for RNA medicine, Aalborg University, Campus Copenhagen, Denmark

h Clinical Proteomic Group, NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

i Dept Clinical Biochemistry, Copenhagen University Hospital Bispebjerg and Frederiksberg, Denmark