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Inicio Allergologia et Immunopathologia Thrombin lag time is increased in children with mild asthma
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Vol. 47. Issue 3.
Pages 241-245 (May - June 2019)
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Vol. 47. Issue 3.
Pages 241-245 (May - June 2019)
Original Article
DOI: 10.1016/j.aller.2018.07.002
Thrombin lag time is increased in children with mild asthma
B.T. Koksala,
Corresponding author

Corresponding author.
, I. Ekerb, N.Y. Ozbekc, I. Dogand, O. Y. Ozbeka
a Department of Pediatric Allergy, Baskent University, Faculty of Medicine, Ankara, Turkey
b Department of Pediatric Hematology, Afyon Kocatepe University, Faculty of Medicine, Afyon, Turkey
c Department of Pediatric Hematology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey
d Department of Biostatistics, Afyon Kocatepe University, Faculty of Medicine, Afyon, Turkey
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Figures (2)
Tables (2)
Table 1. Characteristics of participants in the study.
Table 2. Thrombin generation test parameters according to asthma control.
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Inflammation and coagulation are closely linked events. Thrombin is the key enzyme in coagulation system and also has roles in inflammation.


The aim of our study was to evaluate thrombin generation in children with mild asthma.


Forty-two children with mild asthma and 49 healthy children were included in the study. All patients performed spirometry. Thrombin generation tests (TGT) were performed with a calibrated automated thrombogram (CAT) in children without asthma exacerbation during the last six months. During CAT assay thrombogram curves were obtained. The area under the curve showed endogenous thrombin potentials and indicated the total amount of endogenous thrombin generated; the peak height showed the highest thrombin value, thrombin lag time and time to thrombin peak were measured.


Thrombin lag time was significantly longer in children with asthma (3.98±1.2min) compared to those in the control group (3.29±0.6min) (p<0.01). Children with asthma also had longer thrombin tail time compared to the control group (19.5±8.9min vs. 16.7±2.9min, p=0.02). Thrombin peak was inversely correlated with FEF 25–75 (r=−0.41, p<0.01). Thrombin lag time was inversely correlated with FEF 25–75 (r=−0.39, p<0.01).


Inflammation in mild asthma seems to disturb coagulation but this disturbance may not be so strong as to increase thrombin levels and may only affect the initiation phase of thrombin generation.

Calibrated automated thrombogram (CAT)
Lung function test
Thrombin generation test


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