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Inicio Allergologia et Immunopathologia Correlation of OX40 ligand on B cells with serum total IgE and IL-4 levels by CD...
Journal Information
Vol. 47. Issue 3.
Pages 234-240 (May - June 2019)
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Vol. 47. Issue 3.
Pages 234-240 (May - June 2019)
Original Article
DOI: 10.1016/j.aller.2018.07.003
Correlation of OX40 ligand on B cells with serum total IgE and IL-4 levels by CD4+ T cells in allergic rhinitis
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S. Fouladia, M. Masjedia, M. G. Hakemia, R. Ghasemia, N. Eskandaria,b,
Corresponding author
neskandari@med.mui.ac.ir

Corresponding author.
a Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
b Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
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Tables (2)
Table 1. Characteristics of the study groups.
Table 2. Correlation between the percentages of OX40L+ B cells and other variables among AR patients.
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Abstract
Introduction and objectives

Allergic rhinitis (AR) is a classic Th2-mediated disease, with important contributions to the pathology of interleukins 4, 5, and 13. The co-stimulatory molecule of OX40 and its ligand interaction participate in the immune response by regulation of Th1/Th2 cells balance. Considering the paucity of information on the relation between OX40 ligand (OX40L) and AR, this study aimed to examine its expression on B lymphocytes.

Patients and methods

This case–control study consisted of 20 AR patients and 20 healthy subjects. The serum level of total immunoglobulin E (IgE) was measured using the electro-chemiluminescence (ECL) technology. The percentage of B-lymphocytes expressing OX40L was assessed by flow cytometry. The amounts of IL-4 in CD4+ T cells culture supernatant was also measured by the enzyme-linked immunosorbent assay (ELISA).

Results

OX40L expression on B lymphocytes of patients was significantly higher than the control group (44.32±19.21% vs. 2.79±2.48% respectively, p<0.001). In AR patients, OX40L expression correlated positively with the levels of serum total IgE and IL-4 produced by CD4+ T lymphocytes (p<0.01 – p<0.05) respectively.

Conclusions

Collectively, the findings of this work suggest that there is a relationship between the OX40L expression level on B lymphocytes and allergic markers such as IgE and IL-4 in patients with allergic rhinitis.

Keywords:
OX40 ligand
Immunoglobulin E
Interleukin-4
Allergic rhinitis

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