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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia Predictive factors for progression to chronicity or recurrence after the first a...
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Vol. 47. Issue 5.
Pages 484-490 (September - October 2019)
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Vol. 47. Issue 5.
Pages 484-490 (September - October 2019)
Original Article
DOI: 10.1016/j.aller.2018.12.010
Predictive factors for progression to chronicity or recurrence after the first attack of acute urticaria in preschool-age children
Pinar Gur Cetinkaya*, Ozge Soyer
Corresponding author

Corresponding author.
, Saliha Esenboga, Umit Murat Sahiner, Ozlem Teksam, Bulent Enis Sekerel
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Figures (2)
Tables (3)
Table 1. Demographic characteristics of the study population.
Table 2. Laboratory parameters of the study population.
Table 3. Predictive factors for recurrence following first onset of acute urticaria.
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Introduction and objectives

Preschool-aged group is frequently affected by urticaria, and infections are the most frequently documented factors that cause acute urticaria in children. This prospective study was designed to investigate the underlying factors of acute urticaria in under five-year-old children and to describe predictive factors for progression to chronicity or recurrence after the first attack.

Patients and methods

Children younger than five years of age with acute urticaria were recruited between July 2015 and July 2016. Patients (n=83) were grouped into those below and above two years of age. In order to assess the risk factors for progression to chronicity or recurrence, logistic regression analysis was performed.


Upper respiratory tract infection was the most common detectable reason for acute urticaria (49.4%). Herpes Simplex Virus type 1 was significantly isolated in the cases with the manifestation of an acute single-episode urticaria (p=0.042). Angioedema and food allergy were predominantly observed under two years old (p=0.001, p=0.006 respectively). A positive relationship was determined between the duration of urticaria and chronicity (r=0.301, p=0.006). The absence of atopic dermatitis (OR: 6.95, 95% CI: 1.35–35.67, p=0.020), negative Herpes virus serology (OR: 4.25, 95% CI: 0.83–21.56, p=0.040), and unknown etiology (OR: 3.30, 95% CI: 1.12–9.71, p=0.030) were the independent risk factors for recurrent urticaria.


Preschool-aged children with acute urticaria should be evaluated for infections at the time of admission. Patients with unknown etiology, negative Herpes virus serology, absence of atopic dermatitis, and long lasting urticaria should be followed up for chronicity and recurrence.

Acute urticaria
Risk factors
Preschool-aged children


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