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Inicio Allergologia et Immunopathologia Plasticity of immune system vs. memory therapy IST
Journal Information
Vol. 45. Issue 5.
Pages 482-486 (September - October 2017)
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Vol. 45. Issue 5.
Pages 482-486 (September - October 2017)
Original Article
DOI: 10.1016/j.aller.2017.01.007
Plasticity of immune system vs. memory therapy IST
A. Tammaroa,
Corresponding author

Corresponding author.
, I. Romanoa, F. Persechinob, F.R. Parisellac, I. Trimarchid, S. Persechinoa
a Dermatology Unit*, NESMOS Department, S. Andrea Hospital, University of Rome “Sapienza”, Rome, Italy
b Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
c Premedical School of Medicine, Towson University, Baltimore, USA
d Director Medical Meeting, Italy
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Figures (2)
Tables (6)
Table 1. A first group of 452 patients selected between 1998 and 2000.
Table 2. A second group of 126 patients enrolled between 1998 and 2000.
Table 3. Patients of the 1st group classified for their allergy results.
Table 4. Patients of the 2nd group classified for their allergy results.
Table 5. Patients of the 1st group classified by type therapy ITS.
Table 6. Patients of the 2nd group classified by type therapy ITS.
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Pharmacotherapy and immunotherapy are the main treatments for allergic diseases to inhalants.


This study investigates whether to repeat short cycles of immunotherapy after 3 or 5 years the from interruption of the first therapeutic cycle, lasting 3–4 years, to maintain immune memory in individuals subjected to IST.

Methods and Results

We have compared two groups, one of 452 patients who, after the first treatment for 3–4 years of IST, performed a cycle of four months after three and 10 years from the suspension, and a second group of 126 individuals who have performed only the IST treatment for 3–4 years. The best results were obtained in the first group.


These results are due to the immune system's plasticity, a very important concept in clinical practice.

Biological plasticity


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