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Inicio Allergologia et Immunopathologia Molecular study of hypersensitivity to spores in adults and children from Castil...
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Vol. 47. Issue 4.
Pages 350-356 (July - August 2019)
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Vol. 47. Issue 4.
Pages 350-356 (July - August 2019)
Original Article
DOI: 10.1016/j.aller.2018.10.002
Molecular study of hypersensitivity to spores in adults and children from Castile & Leon
A. Armentiaa,
Corresponding author

Corresponding author.
, S. Martín-Armentiab, A. Morala, D. Montejoa, B. Martin-Armentiaa, R. Sastrea, S. Fernándeza, A. Corellc, D. Fernandezd,e
a Allergy Unit, Hospital Universitario Río Hortega, Valladolid, Spain
b Paediatric Service, Hospital Rio Carrión, Palencia, Spain
c Immunology Department, University of Valladolid, Spain
d Biodiversity and Environmental Management, University of León, León, Spain
e Institute of Atmospheric Sciences and Climate, National Research Council, Bologna, Italy
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Figures (1)
Tables (4)
Table 1. Clinical and epidemiological characteristics of 45 patients allergic to fungi who underwent molecular analysis.
Table 2. Traditional allergic tests. Sensitization to fungi in the three groups studies.
Table 3. Results of molecular tests in 45 patients.
Table 4. Comparison of conventional allergy tests and component-resolved diagnosis in patients with allergy to fungi.
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Introduction and objectives

Biological aerosols play a vital role in the interactions between the atmosphere, biosphere, climate and public health and fungal spores are a component with allergic importance.

We constructed a database in Castile & Leon (Spain) and carry out molecular-level component-resolved diagnosis to complete the air quality study carried out since 2006 by our aerobiological network (RACYL) to aid clinical diagnosis and treatment.


We reviewed a database of 19,774 patients (adults and children) with allergic respiratory disease treated in our unit during the last 12 years. We also made a component-resolved diagnosis of the molecules involved in the pathology in a randomly selected population of 150 patients.


The dimeric glycoprotein Alt a1 from Alternaria is the most prevalent and most useful allergen in the diagnosis of patients with allergy to fungi in our area (94.4%), followed by enolase Alt a 6 (Alternaria), ribonuclease Asp f 1 of Aspergillus and mannitol dehydrogenase from Cla h 8 (Cladosporium).


Our results have helped determine which spore molecules are most-closely associated with allergies. Molecular analysis will be useful to determine more accurate and useful immunotherapy in these patients.

Molecular diagnosis
Mold allergy


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