Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Immunological features in pediatric patients with recurrent and severe infection...
Journal Information
Vol. 47. Issue 5.
Pages 437-448 (September - October 2019)
Download PDF
More article options
Vol. 47. Issue 5.
Pages 437-448 (September - October 2019)
Original Article
DOI: 10.1016/j.aller.2019.02.002
Immunological features in pediatric patients with recurrent and severe infection: Identification of Primary Immunodeficiency Diseases in Merida, Venezuela
N.A. Linaresa, M. Boucharda, N.S. Gutiérreza, M. Colmenaresb, A. Cantor-Garciaa, J.C. Gabaldon-Figueiraa, A.V. Bellorina, B. Rujanoc, D.L. Petersond, S. Salmena,
Corresponding author
a Instituto de Inmunología Clínica, Facultad de Medicina, Universidad de Los Andes, Merida, Venezuela
b Centro de Microscopía Electrónica “Dr Ernesto Palacios Prü”. Universidad de Los Andes, Mérida, Venezuela
c Departamento de Pediatría, Instituto Autónomo Hospital Universitario de Los Andes, Merida, Venezuela
d Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA
Article information
Full Text
Download PDF
Figures (3)
Show moreShow less
Tables (3)
Table 1. RT-PCR primers.
Table 2. PIDs diagnosis and frequency.
Table 3. PIDs characteristic.
Show moreShow less
Introduction and objectives

Primary immunodeficiency diseases (PIDs) are disorders associated mainly with recurrent and severe infection and an increase in susceptibility to autoimmune conditions and cancer. In Venezuela, PIDs are underdiagnosed and there is usually a delay in their diagnosis. Hence there are no data concerning the frequency and type of PIDs that occur. The aim of this study was to identify and quantify the types of PIDs that occur in Merida, a population within Venezuela.

Patients or materials and methods

Following an informative program designed to alert local health professionals to the warning signs for PIDs, patients with a history of recurrent infections were referred to the Instituto de Inmunologia Clinica, Universidad de Los Andes.

Results and conclusions

During the three-year period January 2014 to January 2017, thirty-two cases of PIDs were identified in pediatric patients, and 17 different types of PIDs, were identified. Predominantly antibody deficiencies were most frequent (40.6%), followed by immunodeficiencies affecting cellular and humoral immunity (21.8%), congenital defects of phagocyte (18.7%), CID with associated or syndromic features (9.3%), defects in intrinsic and innate immunity (6.4%) and diseases of immune dysregulation (3.2%). These results have important implications not only to the future approach for management of patients in our regions, but add important knowledge concerning PIDs in Latin America and worldwide.

Immune response
Antibody deficiencies
Immunodeficiencies affecting cellular and humoral immunity
Congenital defects of phagocyte
Defects in intrinsic and innate immunity
Combined immunodeficiency
Immune dysregulation


These are the options to access the full texts of the publication Allergologia et Immunopathologia

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Allergologia et Immunopathologia

Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 22,50 €

Comprar ahora
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.