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Inicio Allergologia et Immunopathologia Increased number of regulatory T cells in esophageal tissue of patients with eos...
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Vol. 47. Issue 5.
Pages 431-436 (September - October 2019)
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Vol. 47. Issue 5.
Pages 431-436 (September - October 2019)
Original Article
DOI: 10.1016/j.aller.2019.02.005
Increased number of regulatory T cells in esophageal tissue of patients with eosinophilic esophagitis in comparison to gastro esophageal reflux disease and control groups
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F. Mousavinasaba,b, D. Babaiec, Y. Nilipoura, M. Mansouric, F. Imanzadehd, N. Darad, P. Rohanid, K. Khatamid, A. Sayyarid, M. Khoddamia, M. Kazemiaghdama, M. Mesdaghib,c,
Corresponding author
mehrnaz_mesdaghi@yahoo.com

Corresponding author.
a Pediatric Pathology Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
b Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
c Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
d Department of Pediatric Gastroentrology and Hepatology, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Table 1. Age and sex of patients in EoE, GERD, and control groups.
Table 2. Characteristics of 28 subjects with EoE, GERD, and controls.
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Abstract
Background

Eosinophilic esophagitis (EoE) is a primarily polygenic allergic disorder. Although most patients have IgE sensitization, it seems that non-IgE mediated responses mainly contribute to the pathogenesis of EoE. Regulatory T cells (Tregs) may have an important role in allergies. There are limited data on the association of Tregs and EoE. In this study, we enumerated and compared T lymphocytes and Tregs in esophageal tissue of patients with EoE, gastroesophageal reflux disease (GERD) and normal controls.

Methods

Ten patients with EoE, ten patients with GERD and eight normal controls were included. Immunohistochemistry staining was used to enumerate T lymphocytes and Tregs. CD3+ cells were considered as T cells and FOXP3+, CD3+ cells were considered as Tregs. T cells and Tregs were counted in 10 high power fields (HPF) (×400) for each patient and the average of 10 HPFs was recorded.

Results

The mean±SEM of Tregs in esophageal tissue of patients with EoE (10.90±2.14cells/HPF) was significantly higher than the GERD (2.77±0.66cells/HPF) and control groups (0.37±0.08cells/HPF) (P<0.001). Additionally, the mean±SEM of T lymphocytes in esophageal tissue of patients with EoE (24.39±3.86cells/HPF) were increased in comparison to the GERD (10.07±2.65cells/HPF) and control groups (3.17±0.93cells/HPF) (P<0.001).

Conclusion

There is an increase in the number of esophageal T lymphocytes and regulatory T cells in patients with EoE compared to the GERD and control groups.

Keywords:
Eosinophilic esophagitis
EoE
GERD
Treg

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