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Inicio Allergologia et Immunopathologia Association between two polymorphisms of histamine-metabolising enzymes and the ...
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Vol. 44. Issue 5.
Pages 433-438 (September - October 2016)
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Vol. 44. Issue 5.
Pages 433-438 (September - October 2016)
Original Article
DOI: 10.1016/j.aller.2016.01.002
Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children
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R. Meza-Velázqueza,b, F. López-Márquezb, S. Espinosa-Padillac, M. Rivera-Guillenb,d, N. Gutíerrez-Díaze, L. Pérez-Armendárizd, M. Rosales-Gonzáleza,
Corresponding author
manuel_rosales_9@hotmail.com

Corresponding author.
a Facultad de Medicina, Universidad Juárez del Estado de Durango, Gómez Palacio, Durango, Mexico
b Facultad de Medicina, Universidad Autonóma de Coahuila, Mexico
c Instituto Nacional de Pediatría, Mexico
d Secretaría de Salud, Torreón, Coahuila, Mexico
e Secretaría de Educación Pública. Durango, Mexico
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Tables (5)
Table 1. Characteristics of the patients.
Table 2. Association between genotypes for HNMT polymorphism, the intensity of symptoms of rhinitis and the number of allergic diseases in each child (asthma, eczema and rhinitis).
Table 3. Association between genotypes for DAO polymorphism with the intensity of symptoms of rhinitis and with the number of allergic diseases in each child (asthma, eczema and rhinitis).
Table 4. Association between haplotype with the intensity of symptoms of rhinitis and with the number of allergic diseases in each child (asthma, eczema and rhinitis).
Table 5. Main characteristics of the allergic children grouped by haplotype.
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Abstract
Background

It has been suggested that polymorphisms of histamine metabolising enzymes can be a risk factor for developing histamine-involving diseases. The aim of the present study is to research the possible association between two functional single nucleotide polymorphisms (SNPs): C314T in the Histamine-N-Methyl Transferase gene and C2029G in the Diamine Oxidase gene, with the severity of allergic rhinitis and the number of allergic diseases, in a group of allergic Mexican children.

Methods

We studied 154 unrelated allergic children. SNPs were analysed by RT-PCR. The total serum IgE was measured by chemiluminescence and the serum histamine by ELISA. We used logistic regression analysis to determine OR.

Results

Patients carrying the mutant allele for any SNP had more risk to develop higher rhinitis severity or a bigger number of allergic diseases. Haplotype analysis revealed that this effect is synergistic. In patients carrying one or two mutant alleles, serum histamine levels were higher than those of patients carrying only wild alleles. Serum IgE levels were not associated with the presence of mutant alleles.

Conclusion

The presence of these SNPs in patients with allergic rhinitis can lead to higher serum histamine, therefore to a higher risk of developing more severe symptoms or more associated allergic diseases, even if the serum IgE remains low.

Keywords:
Allergic rhinitis
Polymorphisms
Diamine oxidase
Histamine
Histamine-N-methyl transferase

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