Buscar en
Revista Española de Nutrición Humana y Dietética
Toda la web
Inicio Revista Española de Nutrición Humana y Dietética Flavonoides como agentes quimiopreventivos y terapéuticos contra el cáncer de ...
Información de la revista
Vol. 16. Núm. 4.
Páginas 143-153 (Octubre - Diciembre 2012)
Descargar PDF
Más opciones de artículo
Vol. 16. Núm. 4.
Páginas 143-153 (Octubre - Diciembre 2012)
DOI: 10.1016/S2173-1292(12)70089-3
Acceso a texto completo
Flavonoides como agentes quimiopreventivos y terapéuticos contra el cáncer de pulmón
Flavonoids as Chemopreventive and Therapeutic Agents Against Lung Cancer
Albert Cabreraa,
Autor para correspondencia

Autor para correspondencia.
, Núria Macha,b
a Àrea de Ciències de la Salut, Institut Internacional de Postgrau de la Universitat Oberta de Catalunya (UOC), Barcelona, España
b INRA, Département de Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France
Información del artículo

El objetivo de la presente revisión es estudiar la relación entre los flavonoides y el cáncer de pulmón, postulando que su consumo habitual en la dieta occidental podría resultar beneficioso para proteger a los pacientes contra el cáncer de pulmón. Se realizó una extensa búsqueda de publicaciones científicas recientes en las siguientes bases de datos electrónicas especializadas: PubMed central (PMC)-NCBI, Elsevier Journal, SciELO España, Scirus y Science Direct, incluyendo estudios en células, animales y humanos sobre el efecto de los flavonoides en la prevención y el desarrollo de cáncer de pulmón. Pese a que los estudios in vitro y en modelos animales muestran la capacidad potencial de los flavonoides para actuar contra diferentes tipos de cáncer, y en especial contra el riesgo de padecer cáncer de pulmón, la presencia de datos contradictorios en los estudios epidemiológicos y la falta de estudios clínicos en humanos actualmente impiden realizar recomendaciones dietéticas basadas en la evidencia científica para los pacientes con cáncer de pulmón. Así, los autores del presente artículo recomiendan seguir los consejos de las guías de alimentación saludable, las cuales promocionan el consumo de alimentos ricos en flavonoides y reflejan el conocimiento necesario para tratar a los pacientes con cáncer de pulmón.

Palabras clave:
Cáncer de pulmón

The objective of the present review is to study the relationship between flavonoids and lung cancer, proposing that their regular consumption in Western diets could be beneficial for protecting patients against lung cancer.

An extensive search of the scientific literature was performed in the following electronic specialized databases (PubMed central (PMC)-NBCI, Elsevier Journal, SciELO Spain, Scirus, Science Direct), including studies in animals, cells, and humans, in order to establish the effect of flavonoids in the prevention and development of lung cancer.Although in vitro and animal studies show the potential ability of flavonoids to act against different types of cancers, especially against lung cancers, the diverse results reported within epidemiological studies, together with the lack of experiments in humans, are the major factors in limiting making dietary recommendations based on scientific evidence for the management of patients with lung cancer. Therefore, the authors of the present study recommend following the dietary health practice guidelines which promotes the consumption of food enriched in flavonoids and reflects the current state of knowledge of an effective and appropriate diet in lung cancer patients.

Lung cancer
El Texto completo está disponible en PDF
W.C. Willett, F. Sacks, A. Trichopoulou, G. Drescher, A. Ferro-Luzzi, E. Helsing, et al.
Mediterranean diet pyramid: a cultural model for healthy eating.
Am J Clin Nutr, 61 (1995), pp. S1402-S1406
H.K. Bielsaki, P. Grimm.
Nutrición texto y atlas.
1.ª ed., Panamericana, (2007),
W. Willett.
Nutrition and cancer: the search continues.
Nutr Cancer, 60 (2008), pp. 557-559
D. Aune, R. Lau, D.S. Chan, R. Vieira, D.C. Greenwood, E. Kampman, et al.
Nonlinear reduction in risk for colorectal cancer by fruit and vegetable intake based on meta-analysis of prospective studies.
Gastroenterology, 141 (2011), pp. 106-118
N. Lunet, C. Valbuena, A.L. Vieira, C. Lopes, L. David, F. Carneiro, et al.
Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis.
Eur J Cancer Prev, 16 (2007), pp. 312-327
M. Pavia, C. Pileggi, C.G. Nobile, I.F. Angelillo.
Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies.
Am J Clin Nutr, 83 (2006), pp. 1126-1134
W.S. Yang, P. Va, M.Y. Wong, H.L. Zhang, Y.B. Xiang.
Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies.
Am J Clin Nutr, 94 (2011), pp. 1575-1583
Y.W. Hwang, S.Y. Kim, S.H. Jee, Y.N. Kim, C.M. Nam.
Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies.
Nutr Cancer, 61 (2009), pp. 598-606
L.M. Butler, A.H. Wu.
Green and black tea in relation to gynecologic cancers.
Mol Nutr Food Res, 55 (2011), pp. 931-940
R.G. Mehta, G. Murillo, R. Naithani, X. Peng.
Cancer chemoprevention by natural products: how far have we come?.
Pharm Res, 27 (2010), pp. 950-961
S.C. Thomasset, D.P. Berry, G. Garcea, T. Marczylo, W.P. Steward, A.J. Gescher.
Dietary polyphenolic phytochemicals –promising cancer chemopreventive agents in humans? A review of their clinical properties.
Int J Cancer, 120 (2007), pp. 451-458
T.B. Mikkelsen, M. Osler, I. Orozova-Bekkevold, V.K. Knudsen, S.F. Olsen.
Association between fruit and vegetable consumption and birth weight: a prospective study among 43,585 Danish women.
Scand J Public Health, 34 (2006), pp. 616-622
D. Malinska, A. Kiersztan.
Flavonoids –characteristics and significance for therapy.
Postepy Biochem, 50 (2004), pp. 182-196
E. Meiyanto, A. Hermawan, A. Anindyajati.
Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents.
Asian Pac J Cancer Prev, 13 (2012), pp. 427-436
A. Murakami, H. Ashida, J. Terao.
Multitargeted cancer prevention by quercetin.
Cancer Lett, 269 (2008), pp. 315-325
A.M. Ekstrom, M. Serafini, O. Nyren, A. Wolk, C. Bosetti, R. Bellocco.
Dietary quercetin intake and risk of gastric cancer: results from a population-based study in Sweden.
Ann Oncol, 22 (2011), pp. 438-443
H. Yao, W. Xu, X. Shi, Z. Zhang.
Dietary flavonoids as cancer prevention agents.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 29 (2011), pp. 1-31
D.F. Birt, S. Hendrich, W. Wang.
Dietary agents in cancer prevention: flavonoids and isoflavonoids.
Pharmacol Ther, 90 (2001), pp. 157-177
M.L. Neuhouser.
Dietary flavonoids and cancer risk: evidence from human population studies.
Nutr Cancer, 50 (2004), pp. 1-7
N.P. Tang, B. Zhou, B. Wang, R.B. Yu, J. Ma.
Flavonoids intake and risk of lung cancer: a meta-analysis.
Jpn J Clin Oncol, 39 (2009), pp. 352-359
I.C. Arts.
A review of the epidemiological evidence on tea, flavonoids, and lung cancer.
J Nutr, 138 (2008), pp. 1561-1566
L. Le Marchand, S.P. Murphy, J.H. Hankin, L.R. Wilkens, L.N. Kolonel.
Intake of flavonoids and lung cancer.
J Natl Cancer Inst, 92 (2000), pp. 154-160
R. Garcia-Closas, A. Agudo, C.A. Gonzalez, E. Riboli.
Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona.
Spain. Nutr Cancer, 32 (1998), pp. 154-158
J. Garcia-Tirado, C. Rieger-Reyes, P. Saz-Peiro.
Effect of flavonoids in the prevention of lung cancer: systematic review.
Med Clin (Barc), 139 (2012), pp. 1-6
P. Knekt, R. Jarvinen, R. Seppanen, M. Hellovaara, L. Teppo, E. Pukkala, et al.
Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.
Am J Epidemiol, 146 (1997), pp. 223-230
T. Hirvonen, J. Virtamo, P. Korhonen, D. Albanes, P. Pietinen.
Flavonol and flavone intake and the risk of cancer in male smokers (Finland).
Cancer Causes Control, 12 (2001), pp. 789-796
L. Wang, I.M. Lee, S.M. Zhang, J.B. Blumberg, J.E. Buring, H.D. Sesso.
Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women.
Am J Clin Nutr, 89 (2009), pp. 905-912
A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, M.J. Thun.
Cancer statistics, 2009.
CA Cancer J Clin, 59 (2009), pp. 225-249
J. Ferlay, D.M. Parkin, E. Steliarova-Foucher.
Estimates of cancer incidence and mortality in Europe in 2008.
Eur J Cancer, 46 (2010), pp. 765-781
S. Egert, G. Rimbach.
Which sources of flavonoids: complex diets or dietary supplements?.
Adv Nutr, 2 (2011), pp. 8-14
G. Williamson, H. Sies, D. Heber, C.L. Keen, I.A. Macdonald, L. Actis-Goretta, et al.
Functional foods for health promotion: state-of-the-science on dietary flavonoids. Extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April 2009.
E. Mlodzinska.
Survey of plant pigments: molecular and environmental determinants of plant colors.
Act Biol Crac Ser Bot, 51 (2009), pp. 7-16
Y. Mo, C. Nagel, L.P. Taylor.
Biochemical complementation of chalcone synthase mutants defines a role for flavonols in functional pollen.
Proc Natl Acad Sci U S A, 89 (1992), pp. 7213-7217
B.R. Wiseman, M. Snook, N.W. Widstrom.
Feeding responses of the corn ear worm larvae (Lepidoptera: Noctuidae) on corn silks of varying flavone content.
J Econ Entomol, 89 (1996), pp. 1040-1044
R.A. Dixon, C.L. Steele.
Flavonoids and isoflavonoids —a gold mine for metabolic engineering.
Trends Plant Sci, 4 (1999), pp. 394-400
E. Grotewold.
The science of flavonoids.
Springer, (2006),
G. Di Carlo, N. Mascolo, A.A. Izzo, F. Capasso.
Flavonoids: old and new aspects of a class of natural therapeutic drugs.
Life Sci, 65 (1999), pp. 337-353
S. Bhagwat, D.B. Haytowitz, J.M. Holden.
USDA Database for the flavonoid content of selected foods.
US Department of Agriculture, (2011),
G.G. Chabot, Y.S. Touil, M.H. Pham, D. Dauzonne.
Flavonoids in cancer prevention and therapy: chemistry, pharmacology, mechanisms of action, and perspectives for cancer drug discovery.
Alternative and complementary therapies for cancer,
D. Grassi, G. Desideri, G. Croce, S. Tiberti, A. Aggio, C. Ferri.
Flavonoids, vascular function and cardiovascular protection.
Curr Pharm Des, 15 (2009), pp. 1072-1084
Y. Huang, S.Y. Tsang, X. Yao, Z.Y. Chen.
Biological properties of baicalein in cardiovascular system.
Curr Drug Targets Cardiovasc Haematol Disord, 5 (2005), pp. 177-184
A. Andres, S.M. Donovan, M.S. Kuhlenschmidt.
Soy isoflavones and virus infections.
J Nutr Biochem, 20 (2009), pp. 563-569
K.S. Mota, G.E. Dias, M.E. Pinto, A. Luiz-Ferreira, A.R. Souza-Brito, C.A. Hiruma-Lima, et al.
Flavonoids with gastroprotective activity.
Molecules, 14 (2009), pp. 979-1012
H. Cheong, S.Y. Ryu, M.H. Oak, S.H. Cheon, G.S. Yoo, K.M. Kim.
Studies of structure activity relationship of flavonoids for the anti-allergic actions.
Arch Pharm Res, 21 (1998), pp. 478-480
J.C. Stoclet, T. Chataigneau, M. Ndiaye, M.H. Oak, J. El Bedoui, M. Chataigneau, et al.
Vascular protection by dietary polyphenols.
Eur J Pharmacol, 500 (2004), pp. 299-313
A.H. Gilani, K.H. Janbaz, B.H. Shah.
Quercetin exhibits hepatoprotective activity in rats.
Biochem Soc Trans, 25 (1997), pp. S619
S. Majumdar, R. Srirangam.
Potential of the bioflavonoids in the prevention/treatment of ocular disorders.
J Pharm Pharmacol, 62 (2010), pp. 951-965
J.P. Spencer.
The impact of fruit flavonoids on memory and cognition.
Br J Nutr, 104 (2010), pp. 40-47
M.K. Chahar, N. Sharma, M.P. Dobhal, Y.C. Joshi.
Flavonoids: A versatile source of anticancer drugs.
Pharmacogn Rev, 5 (2011), pp. 1-12
Y.C. Liao, Y.W. Shih, C.H. Chao, X.Y. Lee, T.A. Chiang.
Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549.
J Agric Food Chem, 57 (2009), pp. 8933-8941
Y.C. Hsiao, W.H. Kuo, P.N. Chen, H.R. Chang, T.H. Lin, W.E. Yang, et al.
Flavanone and 2’-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway.
Chem Biol Interact, 167 (2007), pp. 193-206
X. Cai, T. Ye, C. Liu, W. Lu, M. Lu, J. Zhang, et al.
Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells.
Toxicol In Vitro, 25 (2011), pp. 1385-1391
Y.J. Moon, X. Wang, M.E. Morris.
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.
Toxicol In Vitro, 20 (2006), pp. 187-210
T.T. Nguyen, E. Tran, C.K. Ong, S.K. Lee, P.T. Do, T.T. Huynh, et al.
Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK.
J Cell Physiol, 197 (2003), pp. 110-121
T.T. Nguyen, E. Tran, T.H. Nguyen, P.T. Do, T.H. Huynh, H. Huynh.
The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.
Carcinogenesis, 25 (2004), pp. 647-659
P.C. Kuo, H.F. Liu, J.I. Chao.
Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells.
J Biol Chem, 279 (2004), pp. 55875-55885
B. Kosmider, I. Wojcik, R. Osiecka, J. Bartkowiak, E. Zyner, J. Ochocki, et al.
Enhanced P53 and BAX gene expression and apoptosis in A549 cells by cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP.
Invest New Drugs, 23 (2005), pp. 287-297
D. Schwarz, P. Kisselev, I. Roots.
CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.
Eur J Cancer, 41 (2005), pp. 151-158
W. Chen, X. Wang, J. Zhuang, L. Zhang, Y. Lin.
Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells.
Carcinogenesis, 28 (2007), pp. 2114-2121
H.W. Leung, C.J. Lin, M.J. Hour, W.H. Yang, M.Y. Wang, H.Z. Lee.
Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes.
Food Chem Toxicol, 45 (2007), pp. 2005-2013
L.G. Chen, L.Y. Hung, K.W. Tsai, Y.S. Pan, Y.D. Tsai, Y.Z. Li, et al.
Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells.
Mol Nutr Food Res, 52 (2008), pp. 1349-1357
H.J. Lee, E.O. Lee, S.G. Ko, H.S. Bae, C.H. Kim, K.S. Ahn, et al.
Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis.
Cancer Lett, 270 (2008), pp. 342-353
N. Khan, H. Mukhtar.
Cancer and metastasis: prevention and treatment by green tea.
Cancer Metastasis Rev, 29 (2010), pp. 435-445
G. Du, G. Han, S. Zhang, H. Lin, X. Wu, M. Wang, et al.
Baicalin suppresses lung carcinoma and lung metastasis by SOD mimic and HIF-1alpha inhibition.
Eur J Pharmacol, 630 (2010), pp. 121-130
J.Y. Hung, Y.L. Hsu, Y.C. Ko, Y.M. Tsai, C.J. Yang, M.S. Huang, et al.
Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo.
Lung Cancer, 68 (2010), pp. 366-374
E. Anso, A. Zuazo, M. Irigoyen, M.C. Urdaci, A. Rouzaut, J.J. Martinez-Irujo.
Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.
Biochem Pharmacol, 79 (2010), pp. 1600-1609
H.S. Hsu, J.H. Lin, W.C. Huang, T.W. Hsu, K. Su, S.H. Chiou, et al.
Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27.
Cancer, 117 (2011), pp. 1516-1528
N. Ravichandran, G. Suresh, B. Ramesh, G.V. Siva.
Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcino- genesis in Swiss albino mice.
Food Chem Toxicol, 49 (2011), pp. 1141-1147
A. Hasani, N. Leighl.
Classification and toxicities of vascular disrupting agents.
Clin Lung Cancer, 12 (2011), pp. 18-25
C.Y. Jin, C. Park, H.J. Hwang, G.Y. Kim, B.T. Choi, W.J. Kim, et al.
Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells.
Mol Nutr Food Res, 55 (2011), pp. 300-309
M. Lopez-Lazaro.
Flavonoids as anticancer agents: structure-activity relationship study.
Curr Med Chem Anticancer Agents, 2 (2002), pp. 691-714
G.J. Cutler, J.A. Nettleton, J.A. Ross, L.J. Harnack, D.R. Jacobs Jr., C.G. Scrafford, et al.
Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women's Health Study.
Int J Cancer, 123 (2008), pp. 664-671
J. Mursu, T. Nurmi, T.P. Tuomainen, J.T. Salonen, E. Pukkala, S. Voutilainen.
Intake of flavonoids and risk of cancer in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study.
Int J Cancer, 123 (2008), pp. 660-663
T. Shimazu, M. Inoue, S. Sasazuki, M. Iwasaki, N. Sawada, T. Yamaji, et al.
Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan.
Am J Clin Nutr, 91 (2010), pp. 722-728
T. Shimazu, M. Inoue, S. Sasazuki, M. Iwasaki, N. Sawada, T. Yamaji, et al.
Plasma isoflavones and the risk of lung cancer in women: a nested case-control study in Japan.
Cancer Epidemiol Biomarkers Prev, 20 (2011), pp. 419-427
Copyright © 2012. Asociación Española de Dietistas-Nutricionistas
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos