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Vol. 16. Núm. 4.
Páginas 143-153 (Octubre - Diciembre 2012)
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Vol. 16. Núm. 4.
Páginas 143-153 (Octubre - Diciembre 2012)
DOI: 10.1016/S2173-1292(12)70089-3
Acceso a texto completo
Flavonoides como agentes quimiopreventivos y terapéuticos contra el cáncer de pulmón
Flavonoids as Chemopreventive and Therapeutic Agents Against Lung Cancer
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...
Albert Cabreraa,??
Autor para correspondencia
mvernet@cst.cat

Autor para correspondencia.
, Núria Macha,b
a Àrea de Ciències de la Salut, Institut Internacional de Postgrau de la Universitat Oberta de Catalunya (UOC), Barcelona, España
b INRA, Département de Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France
Información del artículo
Resumen

El objetivo de la presente revisión es estudiar la relación entre los flavonoides y el cáncer de pulmón, postulando que su consumo habitual en la dieta occidental podría resultar beneficioso para proteger a los pacientes contra el cáncer de pulmón. Se realizó una extensa búsqueda de publicaciones científicas recientes en las siguientes bases de datos electrónicas especializadas: PubMed central (PMC)-NCBI, Elsevier Journal, SciELO España, Scirus y Science Direct, incluyendo estudios en células, animales y humanos sobre el efecto de los flavonoides en la prevención y el desarrollo de cáncer de pulmón. Pese a que los estudios in vitro y en modelos animales muestran la capacidad potencial de los flavonoides para actuar contra diferentes tipos de cáncer, y en especial contra el riesgo de padecer cáncer de pulmón, la presencia de datos contradictorios en los estudios epidemiológicos y la falta de estudios clínicos en humanos actualmente impiden realizar recomendaciones dietéticas basadas en la evidencia científica para los pacientes con cáncer de pulmón. Así, los autores del presente artículo recomiendan seguir los consejos de las guías de alimentación saludable, las cuales promocionan el consumo de alimentos ricos en flavonoides y reflejan el conocimiento necesario para tratar a los pacientes con cáncer de pulmón.

Palabras clave:
Flavonoides
Cáncer de pulmón
Quimioprevención
Abstract

The objective of the present review is to study the relationship between flavonoids and lung cancer, proposing that their regular consumption in Western diets could be beneficial for protecting patients against lung cancer.

An extensive search of the scientific literature was performed in the following electronic specialized databases (PubMed central (PMC)-NBCI, Elsevier Journal, SciELO Spain, Scirus, Science Direct), including studies in animals, cells, and humans, in order to establish the effect of flavonoids in the prevention and development of lung cancer.Although in vitro and animal studies show the potential ability of flavonoids to act against different types of cancers, especially against lung cancers, the diverse results reported within epidemiological studies, together with the lack of experiments in humans, are the major factors in limiting making dietary recommendations based on scientific evidence for the management of patients with lung cancer. Therefore, the authors of the present study recommend following the dietary health practice guidelines which promotes the consumption of food enriched in flavonoids and reflects the current state of knowledge of an effective and appropriate diet in lung cancer patients.

Keywords:
Flavonoids
Lung cancer
Chemoprevention
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