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Inicio Revista Española de Nutrición Humana y Dietética Manejo farmacológico en el síndrome anorexia-caquexia
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Vol. 14. Núm. 4.
Páginas 182-186 (Octubre 2010)
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Vol. 14. Núm. 4.
Páginas 182-186 (Octubre 2010)
Acceso a texto completo
Manejo farmacológico en el síndrome anorexia-caquexia
Pharmacological management of cachexia anorexia syndrome
Visitas
...
Esperanza Castejóna,
Autor para correspondencia
ecastejon@hsjdbcn.es

Autor para correspondencia. ecastejon@hsjdbcn.es
, Nilo Lambruschinia, Silvia María Meavillaa, Natalia Catalána
a Sección de Gastroenterología, Hepatología y Nutrición Infantil, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España
Información del artículo
Resumen
Bibliografía
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Estadísticas

La caquexia es un síndrome metabólico complejo caracterizado por anorexia y pérdida de peso que aparece en enfermedades crónicas como el cáncer o la infección por el VIH. La desnutrición en pacientes oncológicos se ha relacionado con peor tolerancia al tratamiento, menor respuesta al tratamiento y peor calidad de vida. Se han empleado distintos fármacos contra la caquexia en pacientes oncológicos. El objetivo de esta revisión es conocer los fármacos disponibles en la actualidad, su mecanismo de acción y sus efectos adversos.

Palabras clave:
Nutrición
Cáncer
Neoplasias
Anorexia
Caquexia
Farmacoterapia

Cachexia is a complex syndrome associated with anorexia and weight loss. This syndrome is very common in chronic diseases such as cancer or HIV diseases. Malnutrition in oncology patients is associated with poorer treatment tolerance, poorer outcomes and a poorer quality of life. The challenge for clinicians is to know how best to manage the symptoms of weight loss and anorexia for optimal patient outcomes. Different treatments have been used in this syndrome. The aim of the present article is to review the different therapeutic approaches and emerging drugs that have been designed to combat and counteract cachexia associated with cancer.

Keywords:
Nutrition
Cancer
Neoplasms
Anorexia
Cachexia
Drug therapy
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Bibliografía
[1]
Hopkinson JB, Wright NM, Foster C..
Management of weight loss and anorexia..
Ann Oncol, 19 (2008), pp. vii289-vii293
[2]
August D, Huhmann D.C.N, The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors. A.S.P.E.N. Clinical Guidelines..
Nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation..
J Parenter Enter Nutr, 33 (2009), pp. 472-500
[3]
Mantovani G, Madeddu C..
Cancer cachexia: medical management..
Support Care Cancer, 18 (2010), pp. 1-9
[4]
Martin E, Belleton F, Lallemand Y, et-al..
Malnutrition in pediatric oncology: prevalence and screening..
Arch Pediatr, 13 (2006), pp. 352-357
[5]
Working Group Bozzetti F, Mariani L..
Defining and classifying cancer cachexia: a proposal by the SCRINIO..
J Parenter Enter Nutr, 33 (2009), pp. 361-367
[6]
Lesniak W, Bala M, Jaeschke R, Krzakowski M..
Effects of megestrol acetate in patients with cancer anorexia-cachexia syndrome —a systematic review and meta-analysis..
Polskie Archuwum Mwdycyny Wewnetrznejm, (2008), pp. 118
[7]
Madeddu C, Macciò A, Panzone F, Tanca FM, Mantovani G..
Medroxyprogesterone acetate in the management of cancer cachexia..
Exp Opin Pharmacother, (2009), pp. 10
[8]
Berenstein EG, Ortiz Z..
Acetato de megestrol para el tratamiento del síndrome de anorexia-caquexia..
Biblioteca Cochrane Plus, (2008),
[9]
González-Villarroel P, Fernández-Pérez I, Páramo C, Gentil M, Carnero B, Vázquez ML, et-al..
Megestrol acetate-induced adrenal insufficiency..
Clin Transl Oncol, 10 (2008), pp. 235-237
[10]
Couluris M, Mayer J, Freyer D, Sandler E, Xu P, Krischer J..
The effect of cyproheptadine hydrochloride (Periactin) and megestrol acetate (Megace) on weight in children with cancer/treatment-related cachexia..
J Pediatr Hematol Oncol, 30 (2008), pp. 791-797
[11]
Argilés JM, Moore-Carrasco R, Fuster G, et-al..
Cancer cachexia: the molecular mechanisms..
Int J Biochem Cell Biol, 35 (2003), pp. 405-409
[12]
Argilés J, López-Soriano FJ, Busquets S..
Emerging drugs for cancer cachexia..
Exp Opin Emerg Drugs, 12 (2007), pp. 555-570
[13]
Argilés J, López-Soriano FJ, Busquets S..
Novel approaches to the treatment of cachexia..
Drug Discovery Today, (2008), pp. 13
[14]
Prommer E..
Palliative oncology: thalidomide..
Am J Hosp Pall Med, (2009), pp. 1-9
[15]
Weyermann P, Dallmann R, Magyar J, Anklin C, Hufschmid M, Dubach-Powell J, et-al..
Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice..
PLoS ONE, 4 (2009), pp. 4774
[16]
Jho D, Babcock T, Tevar R, Helton WS, Espat N.J..
Eicosapentaenoic acid supplementation reduces tumor volume and attenuates cachexia..
JPEN, 26 (2002), pp. 5
[17]
Bayram I, Erbey F, Nilgun C, Nelson J, Atila Tanyeli A..
The use of a protein and energy dense eicosapentaenoic acid containing supplement for malignancy-related weight loss in children..
Pediatr Blood Cancer, 52 (2009), pp. 571-574
[18]
Mazzotta P, Jeney C.M..
Anorexia-cachexia syndrome: a systematic review of the role of dietary polyunsaturated fatty acids in the management of symptoms, survival, and quality of life palliative and supportive care service..
J Pain Symptom Managem, 37 (2008), pp. 1069
[19]
Colomer R, Moreno-Nogueira J, Garcia-Luna P, Garcia-Peris P, Garcia-de-Lorenzo A, Zarazaga A, et-al..
Systematic review n-3 fatty acids, cancer and cachexia: a systematic review of the literature..
Br J Nutr, 97 (2007), pp. 31
[20]
Norren K, Kegler D, Argiles JM, Luiking L, Gorselink M, Laviano A, et-al..
Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice..
Br J Cancer, 100 (2009), pp. 713-722
[21]
Noé J..
l-glutamine use in the treatment and prevention of mucositis and cachexia: a naturopathic perspective..
Integr Cancer Ther, 8 (2009), pp. 409-415
[22]
Loprinzi C, Jatoi A. Pharmacologic management of cancer anorexia/cachexia. Up-ToDate. 2010. Disponible en: http://www.uptodate.com/patients/content/topic.do?topicKey=∼cMk0fpsgNqsAR0..
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