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Vol. 17. Núm. 3.
Páginas 147-171 (Septiembre 2010)
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Vol. 17. Núm. 3.
Páginas 147-171 (Septiembre 2010)
DOI: 10.1016/S0121-8123(10)70075-X
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Historia de los glucocorticoides
History of glucocorticoids
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Humberto Martínez Cordero1, Pablo Montenegro González2, José Félix Restrepo3, Federico Rondón Herrera4, Gerardo Quintana4, Antonio Iglesias Gamarra3
1 Residente de Geriatría, Clínica. Universidad Nacional
2 Residente de Medicina Interna, Universidad Nacional
3 Profesor Titular Facultad de Medicina, Universidad Nacional
4 Profesor Asociado. Facultad de Medicina, Universidad Nacional
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En este artículo hacemos una completa revisión de la Historia de los corticoides desde Thomas Addison quien describió las características de la enfermedad que lleva su nombre, pasando por Edward Kendall quien fue el primero en sintetizar el compuesto E o cortisona, Philipe Hench y su grupo quienes hicieron la aplicación clínica de los glucorticoides en una paciente con artritis reumatoide, hasta llegar a Meyer Hermann con los conceptos actuales sobre ciclo circadioano. Es una historia fascinante que nos permite conocer en detalle todos los pasos que llevaron al descubrimiento de los corticoides y su aplicación clínica en diferentes enfermedades como la artritris reumatoide y el lupus eritematoso sistémico.

Palabras clave:
historia
glucocorticoides
mineralocorticoides
artritis reumatoide
lupus eritematoso sistémico
Summary

In this paper we do a complete review of the history of steroids from Thomas Addison, who described the characteristics of the disease that bears his name, through Edward Kendall who was the first to synthesize the compound E or cortisone, Philipe Hench and his group who made the clinical application of glucocorticoids in a patient with rheumatoid arthritis, up to Hermann Meyer with current concept on circadian rhytms. It is a fascinating story that lets us know in detail all the steps that led to the discovery of steroids and its clinical application in various diseases such as rheumatoid arthritis and systemic lupus erythematosus.

Key words:
history
glucocorticoids
mineralocorticoids
rheumatoid arthritis
systemic lupus erythematosus
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