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Inicio Revista Colombiana de Cardiología Canakinumab: un anticuerpo monoclonal prometedor en el tratamiento de enfermedad...
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Vol. 20. Núm. 1.
Páginas 33-39 (Enero - Febrero 2013)
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Vol. 20. Núm. 1.
Páginas 33-39 (Enero - Febrero 2013)
Open Access
Canakinumab: un anticuerpo monoclonal prometedor en el tratamiento de enfermedades cardiovasculares
Canakinumab: a promising monoclonal antibody in the treatment of cardiovascular diseases
Visitas
...
Fernando Manzur1,2,
Autor para correspondencia
fmanzur1954@hotmail.com

Correspondencia.
, Carlos Moneriz1,
Autor para correspondencia
cmonerizpretel@yahoo.com

Correspondencia.
1 Universidad de Cartagena. Cartagena, Colombia
2 Nuevo Hospital Bocagrande. Cartagena, Colombia
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El canakinumab es un anticuerpo monoclonal anti-IL-1β totalmente humano desarrollado por Novartis, cuyo mecanismo de acción se basa en la neutralización de la señalización IL-1β, lo cual conduce a la supresión de la inflamación en pacientes con trastornos de origen autoinmune. La IL-1β actúa como un mediador de la respuesta inmune periférica durante la infección y la inflamación. Mediante la unión antígeno-anticuerpo el canakinumab inhibe la acción de la IL1-β evitando sus efectos pro-inflamatorios. En la actualidad, está en evaluación como un nuevo posible agente dirigido frente a la IL-1β, con el objetivo de reducir la tasa de eventos cardiovasculares y la diabetes de aparición reciente (estudio CANTOS).

Palabras clave:
factores de riesgo cardiovascular
biomarcadores
diagnóstico

Canakinumab is a totally human monoclonal antibody anti-IL-1β developed by Novartis, whose mode of action is based on the neutralization of IL-1β signaling, which leads to suppression of inflammation in patients with autoimmune disorders. The IL-1β acts as a mediator of the peripheral immune response during infection and inflammation. By the antigen-antibody binding, canakinumab inhibits the action of IL1-β avoiding its pro-inflammatory effects. Currently, it is being evaluated as a new possible agent directed against IL-1β, with the goal of reducing the rate of cardiovascular events and new onset diabetes (study CANTOS).

Keywords:
cardiovascular risk factors
biomarkers
diagnosis
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