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Medicina Clínica (English Edition) Ethical approval and conduct of registered non-pharmacological non-commercial co...
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Vol. 165. Issue 6.
(December 2025)
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Vol. 165. Issue 6.
(December 2025)
Special article
Ethical approval and conduct of registered non-pharmacological non-commercial completed Spanish trials: A systematic review of published reports
Aprobación y conducción ética de los ensayos españoles no farmacológicos, ni comerciales, registrados y completados. Revisión sistemática de los artículos publicados
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Rafael Dal-Réa,
Corresponding author
rafael.dalre@quironsalud.es

Corresponding author.
, Elena García-Méndezb, Ignacio Mahillo-Fernándeza
a Biostatistics and Epidemiology Unit, Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid, Madrid, Spain
b Technical Secretariat, Research Ethics Committee (CEIm), La Paz University Hospital, Health Research Institute La Paz University Hospital, IdiPAZ, Madrid, Spain
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Table 1. Articles of clinical trials that did not report that an independent research ethics committee (REC) approved the protocol, classified according to whether or not they stated that the principles of the Declaration of Helsinki had been followed.
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Table 2. Main characteristics of registered non-pharmacological, non-commercial-sponsored Spanish completed trials in 2009–2024. Trials with published results, published protocol or both. N=499, unless otherwise stated.
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Table 3. Main characteristics of registered non-pharmacological, non-commercial-sponsored Spanish completed trials in 2009–2024. Trials with published results. N=419, unless otherwise stated.
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