Información del artículo
:Como parte del programa de investigación en retinopatía diabética, y utilizando el humor vítreo bovino como material de partida, nuestro grupo ha aislado y caracterizado un nuevo lípido complejo con potente actividad movilizadora de calcio intracelular, no relacionado con ninguno de los factores de crecimiento descritos hasta este momento en el humor vítreo. Este factor lipídico induce movilización de calcio de depósitos intracelulares sensibles a ácido fosfatídico pero no sensibles a D-mio-inositol-1,4,5- trifosfato. Se describe, por una parte, la implicación de factores intrínsecos bioactivos de naturaleza lipídica y, por otra, la activación de “nuevas” rutas de señalización intracelular. La identificación de este tipo de lípidos, con importantes propiedades a escala celular, podría abrir nuevas puertas en el entendimiento de la fisiopatología en el ojo.
Palabras clave:
Retinopatía diabética
Lípidos
Factores de crecimiento
:We have characterized a lipoid agent which is a potent intracelular calcium activater not related to other growth factors in vitreous humor. This agent movilises intracelular calcium sensitive to fosfatidic acid but not sensitive to D-mio-inositol- 1,4,5 triphosphate.
:We describe lipoid bioactive intrinsic factors as new activators of new pathways.
Key words:
Diabetic retinopathy
Lipids
Growth factors
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