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Inicio Archivos de la Sociedad Española de Oftalmología (English Edition) Spironolactone, a therapeutic alternative in the treatment of diffuse retinal pi...
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Vol. 91. Issue 12.
Pages 599-603 (December 2016)
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Vol. 91. Issue 12.
Pages 599-603 (December 2016)
Short communication
Spironolactone, a therapeutic alternative in the treatment of diffuse retinal pigment epitheliopathy
Espironolactona, alternativa terapéutica en el tratamiento de la epiteliopatía difusa crónica
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108
D. Ángel-Pereira
Corresponding author
dangelp300@gmail.com

Corresponding author.
, P. Rocha-Cabrera, L. Cordovés-Dorta, M.J. Losada Castillo, A. Blasco Alberto, J.A. Abreu Reyes
Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
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Abstract
Case report

Two cases are presented of patients with chronic diffuse epitheliopathy (CDE) that showed a favourable response when treated with spironolactone. The first patient had regions of neurosensory detachment (DNS) and the second, multiple DNS, secondary intra-retinal cysts and retinal pigment epithelium detachment.

Discussion

After treatment with spironolactone, both patients showed a visual acuity improvement and structural changes (reduced neurosensory retinal detachment and cystoid degeneration).

Aldosterone receptor agonists (ARA) used for persistent forms of chronic central serous chorioretinopathy show encouraging results and could represent a therapeutic alternative for CDE.

Keywords:
Epitheliopathy
Diffuse
Chronic
Spironolactone
Antagonists
Receptor
Aldosterone
Resumen
Casos clínicos

Se presentan 2 casos clínicos de epiteliopatía difusa crónica (EDC) con respuesta favourable a espironolactona. En el primer paciente se visualizan regiones de desprendimiento neurosensorial (DNS), y en el segundo múltiples DNS, quistes intrarretinianos secundarios y desprendimiento del epitelio pigmentario de la retina.

Discusión

Tras el tratamiento con espironolactona, se observa mejoría de la agudeza visual y de las alteraciones estructurales en ambos pacientes (disminución del DNS y quistes intrarretinianos).

Los fármacos antagonistas de los receptores de aldosterona usados para formas persistentes de coriorretinopatía central serosa (CRCS) tienen resultados alentadores, y podrían ser una alternativa terapéutica en la EDC.

Palabras clave:
Epiteliopatía
Difusa
Crónica
Espironolactona
Antagonistas
Receptores
Aldosterona

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